Extracellular Vesicles from miR-148a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Relieve Hepatic Fibrosis by Targeting Smad4

• Published in: Molecular biotechnology Vol. 64; no. 5; pp. 535 - 545
• Main Authors: Xuan, Ji, Xu, Huabin, Li, Hui, Chen, Desheng, Qiu, Yuping, Chen, Xi, Shao, Mei, Xia, Xianming
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2022; Springer Nature B.V
• Subjects: Actin; Animals; Biochemistry; Bioinformatics; Biological Techniques; Biotechnology; Bone marrow; Calnexin; CD63 antigen; CD9 antigen; Cell Biology; Chemistry; Chemistry and Materials Science; Collagen; Collagen (type I); Collagen - metabolism; Enrichment; Extracellular vesicles; Extracellular Vesicles - genetics; Extracellular Vesicles - metabolism; Fibrosis; Growth factors; Human Genetics; Liver; Liver Cirrhosis - genetics; Liver diseases; Mesenchymal Stem Cells; Metalloproteinase; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Morbidity; mRNA; Muscles; Original Paper; Protein Science; RNA, Messenger - metabolism; Smad4 protein; Smooth muscle; Stellate cells; Stem cell transplantation; Stem cells; Thioacetamide; Tissue inhibitor of metalloproteinase 1; Tissue Inhibitor of Metalloproteinase-1 - genetics; Tissue Inhibitor of Metalloproteinase-1 - metabolism; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - pharmacology; Transforming growth factor-b1; Transmission electron microscopy; Vesicles; Western blotting; miR-148a-5p; Smad4; Liver fibrosis; Extracellular vesicle

Liver fibrosis is a hallmark feature of many chronic liver diseases, which is the leading cause of morbidity and mortality worldwide. Bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles have been applied in many diseases. In this study, we aimed to explore the specific mechanis...