Circulating metabolites of Borneolum syntheticum (Bingpian) ameliorate atherosclerosis in ApoE−/− mice via inhibiting macrophage foam-cell formation

• Published in: Acta pharmacologica Sinica Vol. 46; no. 3; pp. 759 - 776
• Main Authors: He, Rong-rong, Ma, Chuan-rui, He, Xin, Dong, Yan-xi, Li, Hui, Chu, Zi-xuan, Yang, Xi-he, Wang, Jia-qi, Wang, Ting, Wang, Feng-qing, Du, Fei-fei, Rao, Ying, Yu, Wen-xuan, Gao, Xiu-mei, Fan, Guan-wei, Cheng, Chen, Li, Chuan
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.03.2025; Nature Publishing Group
• Subjects: Animals; Apolipoprotein E; Apolipoproteins E - metabolism; Arteriosclerosis; Atherosclerosis; Atherosclerosis - drug therapy; Atherosclerosis - metabolism; Bioavailability; Biomedical and Life Sciences; Biomedicine; Borneol; Camphanes - pharmacology; Camphor; Cardiovascular disease; Coronary artery disease; Diet, High-Fat; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Female; Foam Cells - drug effects; Foam Cells - metabolism; Heart diseases; Herbal medicine; High fat diet; Human subjects; Humans; Immunology; Internal Medicine; Lipoproteins, LDL - metabolism; Macrophages; Male; Medical Microbiology; Membrane permeability; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Pharmacodynamics; Pharmacology/Toxicology; Vaccine; atherosclerosis; isoborneol; metabolism; Bingpian; borneol; Borneolum syntheticum

Translational pharmacological research on traditional medicines lays the foundation for precisely understanding how the medicines function in the body to deliver therapeutic benefits. Borneolum syntheticum (Bingpian) is commonly used in Chinese herbal medicines for coronary heart disease, but its sp...