Silicon, an important exposure marker in vivo in silicosis research

• Published in: International archives of occupational and environmental health Vol. 94; no. 7; pp. 1513 - 1522
• Main Authors: Wang, Hongli, Cui, Jie, Hao, Xiaohui, Guo, Lingli, Zhao, Jinyuan, Wang, Ruimin, Liu, Heliang
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2021; Springer Nature B.V
• Subjects: Administration, Inhalation; Adult; Aged; Animals; Cytokines; Dust; Earth and Environmental Science; Environment; Environmental Health; Enzyme-linked immunosorbent assay; Exposure; Humans; Immunohistochemistry; In vivo methods and tests; Inhalation Exposure; Iron; Lung - drug effects; Lung - immunology; Lung - pathology; Male; Markers; Middle Aged; Mining; Occupational Exposure; Occupational Medicine/Industrial Medicine; Original Article; Pathogenesis; Population studies; Pulmonary Surfactant-Associated Protein D - blood; Rats; Rats, Wistar; Rehabilitation; Serum levels; Signs and symptoms; Silica; Silicon; Silicon - blood; Silicon - urine; Silicon dioxide; Silicon Dioxide - administration & dosage; Silicosis; Silicosis - blood; Silicosis - diagnosis; Silicosis - immunology; Subgroups; Transforming Growth Factor beta1 - blood; Transforming Growth Factor beta1 - immunology; Transforming growth factor-b1; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - immunology; Tumor necrosis factor-α; Urine; Uteroglobin - blood; TGF-β1; SP-D; Silicon; CC16; TNF-α; Silicosis

Purpose The degree of silicosis exposure is closely related to the progress of silicosis. At present, we use animal and human studies to explore whether silicon can be an important exposure marker in the development of silicosis. Methods Rats were randomly divided into 2 groups: (1) controls; and (2...