Modern management of iron overload in thalassemia major patients guided by MRI techniques: real-world data from a long-term cohort study

• Published in: Annals of hematology Vol. 101; no. 3; pp. 521 - 529
• Main Authors: Bayraktaroglu, Selen, Karadas, Nihal, Onen, Sebnem, Karapinar, Deniz Yılmaz, Aydinok, Yesim
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2022; Springer Nature B.V
• Subjects: Adolescent; Adult; beta-Thalassemia - complications; Blood diseases; Chelation therapy; Chelation Therapy - methods; Cohort analysis; Cohort Studies; Deferasirox - therapeutic use; Disease Management; Female; Hematology; Humans; Iron Chelating Agents - therapeutic use; Iron Overload - complications; Iron Overload - therapy; Liver; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Retrospective Studies; Trends; Young Adult; Iron overload; Iron chelation; Thalassemia major; Magnetic resonance imaging; Cardiac iron; Liver iron

Monitoring liver and cardiac iron stores by magnetic resonance imaging (MRI) enables identifying patients at risk of organ-specific morbidity and better tailoring of iron chelation therapy in thalassemia. Nevertheless, serum ferritin (SF) remains the only tool for monitoring iron status in most reso...