Blueberry Extract Modulates Brain Enzymes Activities and Reduces Neuroinflammation: Promising Effect on Lipopolysaccharide-Induced Depressive-Like Behavior

• Published in: Neurochemical research Vol. 48; no. 3; pp. 846 - 861
• Main Authors: Spohr, Luiza, de Aguiar, Mayara Sandrielly Soares, Bona, Natália Pontes, Luduvico, Karina Pereira, Alves, Amália Gonçalves, Domingues, William Borges, Blödorn, Eduardo Bierhals, Bortolatto, Cristiani Folharini, Brüning, César Augusto, Campos, Vinicius Farias, Stefanello, Francieli Moro, Spanevello, Roselia Maria
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2023; Springer Nature B.V
• Subjects: Acetylcholinesterase; Acetylcholinesterase - metabolism; Adenosine Triphosphatases - metabolism; Adenosine Triphosphatases - pharmacology; Amine oxidase (flavin-containing); Animals; Anthocyanins; Anthocyanins - metabolism; Attenuation; Behavior; Behavior, Animal; Binding sites; Biochemistry; Biomedical and Life Sciences; Biomedicine; Blueberries; Brain - metabolism; Brain research; Brain-derived neurotrophic factor; Cell Biology; Cerebral cortex; Cytokines; Depression - chemically induced; Depression - drug therapy; Depression - metabolism; Depressive Disorder, Major - metabolism; Dioxygenase; Enzymes; Fluoxetine; Fluoxetine - pharmacology; Fruits; Galactosides; Gene expression; Hippocampus; Hippocampus - metabolism; Hypotheses; Inflammation; Interleukin 10; Lipopolysaccharides; Lipopolysaccharides - toxicity; Locomotor activity; Male; Mental depression; Mental disorders; Mice; Molecular docking; Molecular Docking Simulation; Monoamine Oxidase - metabolism; Na+/K+-exchanging ATPase; Neurochemistry; Neurogenesis; Neuroinflammatory Diseases; Neurology; Neuroplasticity; Neuroprotection; Neurosciences; Original Paper; Pathophysiology; Polyphenols; Tumor necrosis factor-TNF; Depression; Anthocyanins; Inflammation; Neurotransmission

Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders with high rates of prevalence and mortality. MDD is pathophysiologically complex, and treatment options are limited. Blueberries are rich in polyphenols and have neuroprotective potential. The aim of this study was...