AKT as a Therapeutic Target for Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 6; pp. 1019 - 1031
• Main Authors: Song, Mengqiu, Bode, Ann M., Dong, Zigang, Lee, Mee-Hyun
• Format: Journal Article
• Language: English
• Published: United States 15.03.2019
• Subjects: Animals; Antineoplastic Agents - therapeutic use; Humans; Molecular Targeted Therapy; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Proto-Oncogene Proteins c-akt - antagonists & inhibitors

Many cellular processes in cancer are attributed to kinase signaling networks. V-akt murine thymoma viral oncogene homolog (AKT) plays a major role in the PI3K/AKT signaling pathways. AKT is activated by PI3K or phosphoinositide-dependent kinases (PDK) as well as growth factors, inflammation, and DN...