LncRNA KCNQ1OT1/miR-496/HMGB1 Signaling Axis Promotes Invasion and Migration of Non-small Cell Lung Cancer Cells

• Published in: Biochemical genetics Vol. 62; no. 3; pp. 1994 - 2009
• Main Authors: Wang, Yan, Jiang, Xiao-yun, Qu, Man-ying, Liang, Jie, Yang, Jia-sheng, Sun, Rui-lin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2024; Springer Nature B.V
• Subjects: A549 Cells; Assaying; Biochemistry; Biomedical and Life Sciences; Biomedicine; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Cell Line, Tumor; Cell migration; Cell Movement; Cell Proliferation; Correlation analysis; Gene expression; Gene Expression Regulation, Neoplastic; HMGB1 protein; HMGB1 Protein - genetics; HMGB1 Protein - metabolism; Human Genetics; Humans; KCNQ1OT1 protein; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Medical Microbiology; Metastases; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Neoplasm Invasiveness; Non-coding RNA; Non-small cell lung carcinoma; Original Article; Potassium channels (voltage-gated); Potassium Channels, Voltage-Gated - genetics; Potassium Channels, Voltage-Gated - metabolism; Reporter gene; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Signal Transduction; Small cell lung carcinoma; Tissues; Zoology; lncRNA KCNQ1OT1; ceRNA; HMGB1; miR-496; Non-small cell lung cancer

Enhanced invasion and migration of non-small cell lung cancer (NSCLC) cells is the major cause of metastasis and poor prognosis in NSCLC. This study was conducted to investigate the role and mechanism of lncRNA KCNQ1OT1 in the proliferation, invasion, and migration of NSCLC cells. The expression of...