A Low Tumor Mutational Burden and PTEN Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors

• Published in: Clinical cancer research Vol. 27; no. 13; pp. 3714 - 3724
• Main Authors: Chida, Keigo, Kawazoe, Akihito, Kawazu, Masahito, Suzuki, Toshihiro, Nakamura, Yoshiaki, Nakatsura, Tetsuya, Kuwata, Takeshi, Ueno, Toshihide, Kuboki, Yasutoshi, Kotani, Daisuke, Kojima, Takashi, Taniguchi, Hiroya, Mano, Hiroyuki, Ikeda, Masafumi, Shitara, Kohei, Endo, Itaru, Yoshino, Takayuki
• Format: Journal Article
• Language: English
• Published: United States 01.07.2021
• Subjects: Adult; Aged; Aged, 80 and over; Female; Gastrointestinal Neoplasms - drug therapy; Gastrointestinal Neoplasms - genetics; High-Throughput Nucleotide Sequencing; Humans; Immune Checkpoint Inhibitors - therapeutic use; Male; Microsatellite Instability; Middle Aged; Mutation; PTEN Phosphohydrolase - genetics; Retrospective Studies; Treatment Outcome; Whole Exome Sequencing

This study performed a comprehensive molecular characterization of microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) gastrointestinal (GI) tumors to elucidate predictors of response to PD-1 blockade. Forty-five patients with MSI-H/dMMR GI tumors, including gastric cancer, colo...