Spliced Peptides and Cytokine-Driven Changes in the Immunopeptidome of Melanoma

• Published in: Cancer immunology research Vol. 8; no. 10; p. 1322
• Main Authors: Faridi, Pouya, Woods, Katherine, Ostrouska, Simone, Deceneux, Cyril, Aranha, Ritchlynn, Duscharla, Divya, Wong, Stephen Q, Chen, Weisan, Ramarathinam, Sri H, Lim Kam Sian, Terry C C, Croft, Nathan P, Li, Chen, Ayala, Rochelle, Cebon, Jonathan S, Purcell, Anthony W, Schittenhelm, Ralf B, Behren, Andreas
• Format: Journal Article
• Language: English
• Published: United States 01.10.2020
• ISSN: 2326-6074
• DOI: 10.1158/2326-6066.CIR-19-0894

Antigen recognition by CD8 T cells is governed by the pool of peptide antigens presented on the cell surface in the context of HLA class I complexes. Studies have shown not only a high degree of plasticity in the immunopeptidome, but also that a considerable fraction of all presented peptides is gen...