The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study

• Published in: Applied biochemistry and biotechnology Vol. 194; no. 8; pp. 3749 - 3764
• Main Authors: Penjišević, Jelena Z., Šukalović, Vladimir B., Andrić, Deana B., Suručić, Relja, Kostić-Rajačić, Sladjana V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2022; Springer Nature B.V
• Subjects: absorption; Adrenergic receptors; Anaphylaxis; Angina; Angina pectoris; Animal models; animals; Antifungal agents; Asthma; Biochemistry; Biotechnology; Chemistry; Chemistry and Materials Science; Comparative analysis; computer simulation; Congestive heart failure; excretion; G protein-coupled receptors; heart failure; Hyperplasia; Hypertension; Hyperthyroidism; Hypertrophy; Imidazole; imidazoles; Lead compounds; ligands; Molecular docking; Molecular dynamics; Original Article; Pharmacokinetics; Prostate; Receptors (physiology); therapeutics; Binding assay; Molecular dynamics simulations; Pharmacokinetics; Alpha1-adrenergic receptors; Docking analyses; Arylpiperazines

Adrenergic receptors are among the most studied G protein-coupled receptors. Activation or blockade of these receptors is a major therapeutic approach for the treatment of numerous disorders such as cardiac hypertrophy, congestive heart failure, hypertension, angina pectoris, cardiac arrhythmias, de...