Comprehensive genotyping of Turkish women with hirsutism

• Published in: Journal of endocrinological investigation Vol. 42; no. 9; pp. 1077 - 1087
• Main Authors: Polat, S., Karaburgu, S., Ünlühizarcı, K., Dündar, M., Özkul, Y., Arslan, Y. K., Karaca, Z., Kelestimur, F.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2019; Springer Nature B.V
• Subjects: Adolescent; Adult; Biomarkers - analysis; Cohort Studies; DNA sequencing; Endocrinology; Etiology; Exons; Female; Follow-Up Studies; Genetic analysis; Genotype; Genotyping; Hirsutism; Hirsutism - diagnosis; Hirsutism - epidemiology; Hirsutism - genetics; Humans; Hydroxylase; Hyperplasia; Medicine; Medicine & Public Health; Metabolic Diseases; Mutation; Mutation rates; Original Article; Patients; Polycystic ovary syndrome; Polycystic Ovary Syndrome - physiopathology; Progesterone Reductase - genetics; Prognosis; Promoter Regions, Genetic; Steroid 11-beta-Hydroxylase - genetics; Steroid 11β-hydroxylase; Steroid 21-Hydroxylase - genetics; Turkey - epidemiology; Young Adult; Turkey; NCAH; PCOS; HSD3B2; CYP21A2; CYP11B1

Introduction Hirsutism is a medical sign rather than a disease affects 5–8% of women of reproductive age. Hirsutism is associated with hyperandrogenemia in most patients excluding those with idiopathic hirsutism (IH). The most common cause of hirsutism is polycystic ovary syndrome (PCOS) followed by...