A Critical Functional Missense Mutation (T117M) in Sheep MC4R Gene Significantly Leads to Gain-of-Function

• Published in: Animals (Basel) Vol. 14; no. 15; p. 2207
• Main Authors: Zhao, Ziyi, Yang, Yuta, Liu, Peiyao, Yan, Taotao, Li, Ran, Pan, Chuanying, Li, Yang, Lan, Xianyong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.08.2024
• Subjects: ACTH; Animals; Biotechnology industry; cellular mechanism; Computer software industry; Cyclic adenylic acid; distribution; function mutation; Genes; Genetic aspects; Genetic testing; Genomes; Genotype & phenotype; Homeostasis; MC4R; Mediation; Mutation; Polymorphism; Proteins; worldwide; United States; China; MC4R; worldwide; cellular mechanism; distribution; function mutation

The melanocortin 4 receptor ( ) gene plays a central role in regulating energy homeostasis and food intake in livestock, thereby affecting their economic worth and growth. In a previous study, the p.T117M mutation in the sheep gene, which leads to the transition of threonine to methionine, was found...