Spatial Navigation: Implications for Animal Models, Drug Development and Human Studies

Spatial navigation and memory is considered to be a part of the declarative memory system and it is widely used as an animal model of human declarative memory. However, spatial tests typically involve only static settings, despite the dynamic nature of the real world. Animals, as well as people cons...

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Published inPhysiological research Vol. 63 Suppl 1; pp. S237 - S249
Main Authors STUCHLIK, A., KUBIK, S., VLCEK, K., VALES, K.
Format Journal Article
LanguageEnglish
Published Czech Republic Institute of Physiology 01.01.2014
Subjects
Animal behavior
Animal memory
Animals
Brain
Brain - drug effects
Brain - physiology
Central Nervous System Agents - pharmacology
Cognitive models
Drug Design
Humans
Maze Learning - drug effects
Maze Learning - physiology
Memory - drug effects
Memory - physiology
Neurogenesis
Rodents
Space Perception - drug effects
Space Perception - physiology
Spatial Behavior - drug effects
Spatial Behavior - physiology
Studies
Online AccessGet full text
ISSN0862-8408
1802-9973
DOI10.33549/physiolres.932660

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Abstract Spatial navigation and memory is considered to be a part of the declarative memory system and it is widely used as an animal model of human declarative memory. However, spatial tests typically involve only static settings, despite the dynamic nature of the real world. Animals, as well as people constantly need to interact with moving objects, other subjects or even with entire moving environments (flowing water, running stairway). Therefore, we design novel spatial tests in dynamic environments to study brain mechanisms of spatial processing in more natural settings with an interdisciplinary approach including neuropharmacology. We also translate data from neuropharmacological studies and animal models into development of novel therapeutic approaches to neuropsychiatric disorders and more sensitive screening tests for impairments of memory, thought, and behavior.
AbstractList Spatial navigation and memory is considered to be a part of the declarative memory system and it is widely used as an animal model of human declarative memory. However, spatial tests typically involve only static settings, despite the dynamic nature of the real world. Animals, as well as people constantly need to interact with moving objects, other subjects or even with entire moving environments (flowing water, running stairway). Therefore, we design novel spatial tests in dynamic environments to study brain mechanisms of spatial processing in more natural settings with an interdisciplinary approach including neuropharmacology. We also translate data from neuropharmacological studies and animal models into development of novel therapeutic approaches to neuropsychiatric disorders and more sensitive screening tests for impairments of memory, thought, and behavior.
Spatial navigation and memory is considered to be a part of the declarative memory system and it is widely used as an animal model of human declarative memory. However, spatial tests typically involve only static settings, despite the dynamic nature of the real world. Animals, as well as people constantly need to interact with moving objects, other subjects or even with entire moving environments (flowing water, running stairway). Therefore, we design novel spatial tests in dynamic environments to study brain mechanisms of spatial processing in more natural settings with an interdisciplinary approach including neuropharmacology. We also translate data from neuropharmacological studies and animal models into development of novel therapeutic approaches to neuropsychiatric disorders and more sensitive screening tests for impairments of memory, thought, and behavior. [PUBLICATION ABSTRACT]
Author VLCEK, K.
VALES, K.
STUCHLIK, A.
KUBIK, S.
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Snippet Spatial navigation and memory is considered to be a part of the declarative memory system and it is widely used as an animal model of human declarative memory....
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SubjectTerms Animal behavior
Animal memory
Animals
Brain
Brain - drug effects
Brain - physiology
Central Nervous System Agents - pharmacology
Cognitive models
Drug Design
Humans
Maze Learning - drug effects
Maze Learning - physiology
Memory - drug effects
Memory - physiology
Neurogenesis
Rodents
Space Perception - drug effects
Space Perception - physiology
Spatial Behavior - drug effects
Spatial Behavior - physiology
Studies
Title Spatial Navigation: Implications for Animal Models, Drug Development and Human Studies
URI https://www.ncbi.nlm.nih.gov/pubmed/24564663
https://www.proquest.com/docview/1511803510
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