Arnicolide D: a multi-targeted anticancer sesquiterpene lactone—preclinical efficacy and mechanistic insights

• Published in: Naunyn-Schmiedeberg's archives of pharmacology Vol. 397; no. 9; pp. 6317 - 6336
• Main Authors: Mangalpady, Shivaprasad Shetty, Peña-Corona, Sheila I., Borbolla-Jiménez, Fabiola, Kaverikana, Rajesh, Shetty, Shobhitha, Shet, Vinayaka Babu, Almarhoon, Zainab M., Calina, Daniela, Leyva-Gómez, Gerardo, Sharifi-Rad, Javad
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2024; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animals; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Antineoplastic Agents, Phytogenic - pharmacokinetics; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Apoptosis; Apoptosis - drug effects; Archives & records; Asthma; Biomedical and Life Sciences; Biomedicine; Breast cancer; Breast carcinoma; Cancer therapies; Cell culture; Cell cycle; Cell growth; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Chemistry; Clinical trials; Colon; Colon cancer; Colorectal cancer; Cytotoxicity; Dosage; Herbal medicine; Humans; Infections; Keywords; Lactones - pharmacology; Lactones - therapeutic use; Medical Subject Headings-MeSH; Metastases; Metastasis; Molecular modelling; Nasopharyngeal carcinoma; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Neurosciences; Pharmacokinetics; Pharmacology; Pharmacology/Toxicology; Pharmacy; Prostate cancer; Review; Sesquiterpenes - pharmacokinetics; Sesquiterpenes - pharmacology; Sesquiterpenes - therapeutic use; Signal Transduction - drug effects; Stat3 protein; Throat cancer; TOR protein; Toxicity testing; Tumor cell lines; Anti-cancer mechanisms; Sesquiterpene lactone, Src degradation; PI3K/AKT/mTOR pathway; Arnicolide D; Apoptosis; Centipeda minima
• ISSN: 0028-1298; 1432-1912; 1432-1912
• DOI: 10.1007/s00210-024-03095-7

Arnicolide D, a potent sesquiterpene lactone from Centipeda minima , has emerged as a promising anticancer candidate, demonstrating significant efficacy in inhibiting cancer cell proliferation, inducing apoptosis, and suppressing metastasis across various cancer models. This comprehensive study delv...