Canagliflozin mitigates ferroptosis and improves myocardial oxidative stress in mice with diabetic cardiomyopathy

• Published in: Frontiers in endocrinology (Lausanne) Vol. 13; p. 1011669
• Main Authors: Du, Shuqin, Shi, Hanqiang, Xiong, Lie, Wang, Ping, Shi, Yanbo
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 14.10.2022
• Subjects: canagliflozin; diabetic cardiomyopathy; Endocrinology; ferroptosis; lipid peroxidation; mitochondria; sodium-glucose cotransporter 2 inhibitor

Canagliflozin (Cana), an anti-diabetes drug belongs to sodium-glucose cotransporter 2 inhibitor, is gaining interest because of its extra cardiovascular benefits. Ferroptosis is a new mode of cell death, which can promote the occurrence of diabetic cardiomyopathy (DCM). Whether Cana can alleviate DC...