Longitudinal bone microarchitectural changes are best detected using image registration

• Published in: Osteoporosis international Vol. 31; no. 10; pp. 1995 - 2005
• Main Authors: Kemp, T.D., de Bakker, C.M.J., Gabel, L., Hanley, D.A., Billington, E.O., Burt, L.A., Boyd, S.K.
• Format: Journal Article
• Language: English
• Published: London Springer London 01.10.2020; Springer Nature B.V
• Subjects: Aged; Bone and Bones; Bone Density; Bone imaging; Bone mineral density; Computed tomography; Endocrinology; Female; Humans; Image processing; Longitudinal studies; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Orthopedics; Osteoporosis; Physiology; Radius; Radius - diagnostic imaging; Registration; Rheumatology; Tibia; Tibia - diagnostic imaging; Tomography, X-Ray Computed; Least significant change; HR-pQCT; Longitudinal analysis; Bone density; 3D registration; Bone microarchitecture

Summary Longitudinal studies of bone using high-resolution medical imaging may result in non-physiological measurements of longitudinal changes. In this study, we determined that three-dimensional image processing techniques best capture realistic longitudinal changes in bone density and should ther...