Approximating subject-specific brain injury models via scaling based on head–brain morphological relationships

• Published in: Biomechanics and modeling in mechanobiology Vol. 22; no. 1; pp. 159 - 175
• Main Authors: Wu, Shaoju, Zhao, Wei, Wu, Zheyang, McAllister, Thomas, Hu, Jingwen, Ji, Songbai
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2023; Springer Nature B.V
• Subjects: Age; Approximation; Biological and Medical Physics; Biomedical Engineering and Bioengineering; Biophysics; Brain; Engineering; Finite element method; Geometric accuracy; Head; Head injuries; Model accuracy; Morphology; Neuroimaging; Original Paper; Regression analysis; Regression models; Sex; Substantia alba; Theoretical and Applied Mechanics; Traumatic brain injury; Brain injury model; Head morphology; Concussion; Subject-specific model; Worcester head injury model (WHIM)

Most human head/brain models represent a generic adult male head/brain. They may suffer in accuracy when investigating traumatic brain injury (TBI) on a subject-specific basis. Subject-specific models can be developed from neuroimages; however, neuroimages are not typically available in practice. In...