Approximating subject-specific brain injury models via scaling based on head–brain morphological relationships

• Published in: Biomechanics and modeling in mechanobiology Vol. 22; no. 1; pp. 159 - 175
• Main Authors: Wu, Shaoju, Zhao, Wei, Wu, Zheyang, McAllister, Thomas, Hu, Jingwen, Ji, Songbai
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2023; Springer Nature B.V
• Subjects: Age; Approximation; Biological and Medical Physics; Biomedical Engineering and Bioengineering; Biophysics; Brain; Engineering; Finite element method; Geometric accuracy; Head; Head injuries; Model accuracy; Morphology; Neuroimaging; Original Paper; Regression analysis; Regression models; Sex; Substantia alba; Theoretical and Applied Mechanics; Traumatic brain injury; Brain injury model; Head morphology; Concussion; Subject-specific model; Worcester head injury model (WHIM)
• ISSN: 1617-7959; 1617-7940; 1617-7940
• DOI: 10.1007/s10237-022-01638-6

Most human head/brain models represent a generic adult male head/brain. They may suffer in accuracy when investigating traumatic brain injury (TBI) on a subject-specific basis. Subject-specific models can be developed from neuroimages; however, neuroimages are not typically available in practice. In this study, we establish simple and elegant regression models between brain outer surface morphology and head dimensions measured from neuroimages along with age and sex information ( N  = 191; 141 males and 50 females with age ranging 14–25 years). The regression models are then used to approximate subject-specific brain models by scaling a generic counterpart, without using neuroimages. Model geometrical accuracy is assessed using adjusted R 2 and absolute percentage error (e.g., 0.720 and 3.09 ± 2.38%, respectively, for brain volume when incorporating tragion-to-top). For a subset of 11 subjects (from smallest to largest in brain volume), impact-induced brain strains are compared with those from “morphed models” derived from neuroimage-based mesh warping. We find that regional peak strains from the scaled subject-specific models are comparable to those of the morphed counterparts but could be considerably different from those of the generic model (e.g., linear regression slope of 1.01–1.03 for gray and white matter regions versus 1.16–1.19, or up to ~ 20% overestimation for the smallest brain studied). These results highlight the importance of incorporating brain morphological variations in impact simulation and demonstrate the feasibility of approximating subject-specific brain models without neuroimages using age, sex, and easily measurable head dimensions. The scaled models may improve subject specificity for future TBI investigations.