Antiviral Efficacy of Abacavir in Antiretroviral Therapy-Experienced Adults Harbouring HIV-1 with Specific Patterns of Resistance to Nucleoside Reverse Transcriptase Inhibitors

• Published in: Antiviral therapy Vol. 9; no. 1; pp. 37 - 45
• Main Authors: Lanier, E Randall, Ait-Khaled, Mounir, Scott, Janna, Stone, Chris, Melby, Thomas, Sturge, Glenn, Clair, Marty St, Steel, Helen, Hetherington, Seth, Pearce, Gillian, Spreen, William, Lafon, Stephen
• Format: Journal Article
• Language: English
• Published: London International Medical Press 01.02.2004
• Subjects: Acquired Immunodeficiency Syndrome - drug therapy; Adult; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; CD4 Lymphocyte Count; Dideoxynucleosides - therapeutic use; Drug Resistance, Viral - drug effects; Drug Resistance, Viral - genetics; HIV-1 - drug effects; HIV-1 - genetics; Humans; Medical sciences; Mutation; Pharmacology. Drug treatments; Phenotype; Regression Analysis; Retrospective Studies; Reverse Transcriptase Inhibitors - therapeutic use; RNA, Viral - blood; RNA, Viral - isolation & purification; Treatment Failure; Treatment Outcome; Purine nucleoside; RNA-directed DNA polymerase; HIV-1 virus; Reverse transcriptase inhibitor; Adult; Antiviral; Nucleoside; Human; Immunopathology; Enzyme; Transferases; Retroviridae; Enzyme inhibitor; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Resistance; Nucleotidyltransferases; Chemotherapy; Treatment; Viral disease; Abacavir; Human immunodeficiency virus; Nucleosidic analog

To evaluate HIV-1 reverse transcriptase genotypic and phenotypic indicators of resistance to abacavir (ABC) as predictors of ABC antiviral efficacy. The study was a retrospective, combined analysis of five multicentre trials in which ABC was added as a single agent to background antiretroviral thera...