Upregulation of TTYH3 promotes epithelial-to-mesenchymal transition through Wnt/β-catenin signaling and inhibits apoptosis in cholangiocarcinoma

• Published in: Cellular oncology (Dordrecht) Vol. 44; no. 6; pp. 1351 - 1361
• Main Authors: Xue, Weijie, Dong, Bingzi, Zhao, Yanjie, Wang, Yixiu, Yang, Chenyu, Xie, Yuwei, Niu, Zhaojian, Zhu, Chengzhan
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2021; Springer Nature B.V
• Subjects: Animals; Apoptosis; Apoptosis - genetics; beta Catenin - metabolism; Bile Duct Neoplasms - metabolism; Bile ducts; Bile Ducts, Intrahepatic - metabolism; Bile Ducts, Intrahepatic - pathology; Biomedical and Life Sciences; Biomedicine; Calcium channels; Calcium chloride; Cancer Research; Cell culture; Cell Line, Tumor; Cell Movement - genetics; Cell proliferation; Cell Proliferation - genetics; Chloride channels (calcium-gated); Chloride Channels - genetics; Cholangiocarcinoma; Cholangiocarcinoma - metabolism; CpG islands; Deoxyribonucleic acid; DNA; DNA methylation; E-cadherin; Epithelial-Mesenchymal Transition - genetics; Epithelium; Gene expression; Gene Expression Regulation, Neoplastic; Humans; Mesenchyme; Metastases; mRNA; N-Cadherin; Oncology; Original Article; Pathology; Signal transduction; Tumors; Up-Regulation - genetics; Vimentin; Wnt protein; Wnt Signaling Pathway; Xenografts; β-Catenin; Epithelial-mesenchymal transition; TTYH3; Migration; Wnt/β-catenin; DNA methylation; Proliferation; Cholangiocarcinoma

Purpose Cholangiocarcinoma (CCA) is a highly invasive malignant tumor originating from the bile duct epithelium. Tweety homolog 3 (TTYH3) is a member of the family of calcium-activated chloride channels, which have several biological functions. Here, we aimed to investigate the expression and biolog...