Lactate dehydrogenase A inhibitors with a 2,8-dioxabicyclo[3.3.1]nonane scaffold: A contribution to molecular therapies for primary hyperoxalurias - Alejo-Armijo, Alfonso; Cuadrado, Cristina; Altarejos, Joaquin; Fernandes, Miguel X.; Salido, Eduardo; Diaz-Gavilan, Monica; Salido, Sofia (Bioorganic chemistry, 2022)
Keywords: 2,8-Dioxabicyclo[3.3.1]nonane scaffold; Alkanes; Animals; Biochemistry & Molecular Biology; Chemistry; Chemistry, Organic; Flavylium salts; Humans; Hyperoxaluria, Primary - genetics; Hyperoxaluria, Primary - metabolism; Hyperoxaluria, Primary - pathology; Hyperoxaluric mouse hepatocytes; Lactate Dehydrogenase 5; Life Sciences & Biomedicine; Mice; Oxalate; Oxalates - metabolism; Physical Sciences; Primary hyperoxaluria; Science & Technology; Selective lactate dehydrogenase A inhibitors; Selective lactate dehydrogenase A inhibitors; Primary hyperoxaluria; Flavylium salts; Oxalate; Hyperoxaluric mouse hepatocytes; 2,8-Dioxabicyclo[3.3.1]nonane scaffold; TARGET; HYDROXYPROLINE METABOLISM; ANALOGS; LIGHT; DISCOVERY; GLYCOLATE OXIDASE; MOUSE MODEL; PROCYANIDINS; 28-Dioxabicyclo[3.3.1]nonane scaffold; STEREOSELECTIVE-SYNTHESIS