Paradoxical adverse drug reactions: descriptive analysis of French reports

• Published in: European journal of clinical pharmacology Vol. 76; no. 8; pp. 1169 - 1174
• Main Authors: Hakimi, Yan, Petitpain, Nadine, Pinzani, Véronique, Montastruc, Jean-Louis, Bagheri, Haleh
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2020; Springer Nature B.V
• Subjects: Addictions; Adult; Adverse Drug Reaction Reporting Systems - statistics & numerical data; Aged; Benzodiazepines; Biomedical and Life Sciences; Biomedicine; Classification; Cognitive ability; Databases, Factual; Donepezil; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drugs; Female; France - epidemiology; Humans; Immunomodulators; Male; Mental disorders; Middle Aged; Pharmacodynamics; Pharmacoepidemiology and Prescription; Pharmacology/Toxicology; Pharmacovigilance; Psychotropic drugs; Sleep; Young Adult; France; Immunomodulating agents; Paradoxical adverse drug reactions; Pharmacovigilance; Drug safety; Benzodiazepines

Introduction Paradoxical adverse drug reactions (ADRs) are defined as being opposing reactions to the pharmacological effect of drugs in relation to its pharmacodynamic properties. Their diagnosis is difficult as they are relatively rare with atypical clinical presentation (with the possibility of b...