An Aedes–Anopheles Vaccine Candidate Supplemented with BCG Epitopes Against the Aedes and Anopheles Genera to Overcome Hypersensitivity to Mosquito Bites

• Published in: Acta parasitologica Vol. 69; no. 1; pp. 483 - 504
• Main Authors: Naveed, Muhammad, Ali, Urooj, Aziz, Tariq, Naveed, Rida, Mahmood, Sarmad, Khan, Muhammad Mustajab, Alharbi, Metab, Albekairi, Thamer H., Alasmari, Abdullah F.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2024; Springer Nature B.V
• Subjects: Aedes; Aedes - immunology; Allergies; Anaphylaxis; Animal Systematics/Taxonomy/Biogeography; Animals; Anopheles; Anopheles - immunology; Antigens; Aquatic insects; Biomedical and Life Sciences; Biomedicine; Clinical trials; Deformability; Ecology; Eigenvalues; Epitopes; Epitopes - immunology; Formability; Free energy; Helper cells; Humans; Hypersensitivity; Hypersensitivity - immunology; Hypersensitivity - prevention & control; Immune response; Immune system; Immunotherapy; Insect bites; Insect Bites and Stings - immunology; Insect Bites and Stings - prevention & control; Lymphocytes T; Medical Microbiology; Microbiology; Molecular interactions; Mosquitoes; Original Paper; Parasitology; Pattern recognition; Pattern recognition receptors; Solubility; Thermal stability; TLR2 protein; Toll-like receptors; Vaccines; Vaccines - immunology; Venom; vaccine; –; TH1-mediated response; Bacillus Calmette–Guérin epitopes; Immune simulations; Skeeter syndrome; Molecular docking; Aedes–Anopheles vaccine

Background Skeeter syndrome is a severe local allergic response to mosquito bites that is accompanied by considerable inflammation and, in some cases, a systemic response like fever. People with the syndrome develop serious allergies, ranging from rashes to anaphylaxis or shock. The few available st...