Time-course of pain and salivary opiorphin release in response to oral capsaicin differ in burning mouth syndrome patients, temporomandibular disorders patients and control subjects

• Published in: Clinical oral investigations Vol. 28; no. 5; p. 246
• Main Authors: Alajbeg, Iva Z., Vrbanovic, Ema, Alajbeg, Ivan, Orabovic, Ivan, Naka, Klara, Mrla, Antonija, Boucher, Yves
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 09.04.2024; Springer Nature B.V
• Subjects: Adult; Analgesics; Animal models; Burning Mouth Syndrome; Capsaicin; Capsaicin receptors; Clinical trials; Dentistry; Facial Pain; High-performance liquid chromatography; Humans; Medicine; Oligopeptides; Pain; Pain management; Pain perception; Pathophysiology; Patients; Salivary gland; Salivary Proteins and Peptides; Sampling; Sensitivity analysis; Temporomandibular joint; Temporomandibular joint disorders; Temporomandibular disorders; Pain; Burning mouth syndrome; Capsaicin; Opiorphin; Saliva

Objectives Opiorphin is an analgesic peptide released by salivary glands and capsaicin an agonist of TRPV1 receptors eliciting burning sensations. The primary objective of this study was to assess opiorphin release after stimulation of the tongue by capsaicin (STC). The secondary objectives were to...