Circulating tumor DNA assisting lymphoma genetic feature profiling and identification

• Published in: Annals of hematology Vol. 103; no. 10; pp. 4135 - 4144
• Main Authors: Wang, Hongbiao, Wang, Zhao, Zhu, Sujuan, Li, Zhifeng, Yang, Hang, Sun, Peng, Zhu, Minyi, Zhao, Xiaotian, Shen, Lu, Ou, Qiuxiang, Yang, Hui, Li, Zhi-Ming
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2024; Springer Nature B.V
• Subjects: Adult; Aged; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Biopsy; Circulating Tumor DNA - blood; Circulating Tumor DNA - genetics; Female; Hematology; High-Throughput Nucleotide Sequencing; Hodgkin Disease - blood; Hodgkin Disease - diagnosis; Hodgkin Disease - genetics; Humans; Lymphoma; Lymphoma, Large B-Cell, Diffuse - blood; Lymphoma, Large B-Cell, Diffuse - diagnosis; Lymphoma, Large B-Cell, Diffuse - genetics; Male; Mediastinal Neoplasms - genetics; Medicine; Medicine & Public Health; Middle Aged; Mutation; Oncology; Disease surveillance; Lymphoma; Primary mediastinal large B-cell lymphoma; Circulating tumor DNA; Classic Hodgkin lymphoma; Diffuse large B-cell lymphoma

Introduction Lymphoma tissue biopsies cannot fully capture genetic features due to accessibility and heterogeneity. We aimed to assess the applicability of circulating tumor DNA (ctDNA) for genomic profiling and disease surveillance in classic Hodgkin lymphoma (cHL), primary mediastinal large B-cell...