TLR7 Promotes Tumor Progression, Chemotherapy Resistance, and Poor Clinical Outcomes in Non–Small Cell Lung Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 74; no. 18; pp. 5008 - 5018
• Main Authors: Chatterjee, Saradiya, Crozet, Lucile, Damotte, Diane, Iribarren, Kristina, Schramm, Catherine, Alifano, Marco, Lupo, Audrey, Cherfils-Vicini, Julien, Goc, Jeremy, Katsahian, Sandrine, Younes, Mohammad, Dieu-Nosjean, Marie Caroline, Fridman, Wolf Herman, Sautès-Fridman, Catherine, Cremer, Isabelle
• Format: Journal Article
• Language: English
• Published: United States 15.09.2014
• Subjects: Animals; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - metabolism; Cell Line, Tumor; Disease Progression; Female; Guanosine - analogs & derivatives; Guanosine - pharmacology; Humans; Lung Neoplasms - drug therapy; Lung Neoplasms - metabolism; Membrane Glycoproteins - agonists; Membrane Glycoproteins - metabolism; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Signal Transduction; Toll-Like Receptor 7 - agonists; Toll-Like Receptor 7 - metabolism

Toll-like receptors (TLR) recognize pathogen molecules and danger-associated signals that stimulate inflammatory processes. TLRs have been studied mainly in antigen-presenting cells, where they exert important immune regulatory functions, but they are also expressed by epithelial tumor cells, where...