Cadmium Exposure Induces Inflammation Through Oxidative Stress-Mediated Activation of the NF-κB Signaling Pathway and Causes Heat Shock Response in a Piglet Testis

• Published in: Biological trace element research Vol. 203; no. 8; pp. 4128 - 4138
• Main Authors: Li, Yulong, Wang, Hongbao, Wang, Yanfei
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2025; Springer Nature B.V
• Subjects: Animals; Antioxidants; Biochemistry; Biomedical and Life Sciences; Biotechnology; Cadmium; Cadmium - toxicity; Calcium; Catalase; Copper; Cyclooxygenase-2; Enzymes; Exposure; Fluorescence; Glutathione; Glutathione peroxidase; Heat shock; Heat shock proteins; Heat-Shock Response - drug effects; Hsp60 protein; Hsp70 protein; Hsp90 protein; Hydrogen peroxide; Inflammation; Inflammation - chemically induced; Inflammation - metabolism; Inflammation - pathology; Inflammatory response; Injuries; Interleukin 6; Iron; Life Sciences; Male; Malondialdehyde; Manganese; mRNA; NF-kappa B - metabolism; NF-κB protein; Nitric oxide; Nitric-oxide synthase; Nutrition; Oncology; Oxidative stress; Oxidative Stress - drug effects; Peroxidase; Selenium; Signal transduction; Signal Transduction - drug effects; Superoxide dismutase; Swine; Testes; Testis - drug effects; Testis - metabolism; Testis - pathology; Toxins; Trace elements; Zinc; Heat shock response; Cadmium; Oxidative stress; Piglet testis; Inflammation

Cadmium (Cd), recognized as an environmental toxin, can cause injury to the testis in humans and animals. Oxidative stress (OS) can trigger an inflammatory response by promoting the activation of nuclear factor kappa beta (NF-κB) signaling pathway. Meanwhile, inflammation can lead to the occurrence...