Piceatannol improved cerebral blood flow and attenuated JNK3 and mitochondrial apoptotic pathway in a global ischemic model to produce neuroprotection

• Published in: Naunyn-Schmiedeberg's archives of pharmacology Vol. 397; no. 1; pp. 479 - 496
• Main Authors: Rajan, Ravi Kumar, Kumar, Ram Pravin, Ramanathan, M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 2024; Springer Nature B.V
• Subjects: Amino acids; Amino Acids - pharmacology; Animals; Apoptosis; Biomedical and Life Sciences; Biomedicine; Blood flow; Brain Ischemia - metabolism; c-Jun protein; Caspase; Cerebral blood flow; Cerebrovascular Circulation; Gene expression; Inflammation; Ischemia; JNK Mitogen-Activated Protein Kinases; JNK protein; JNK3 protein; Kinases; Mitochondria; Mitogen-Activated Protein Kinase 10 - metabolism; Molecular Docking Simulation; Neuroprotection; Neurosciences; Nitric-oxide synthase; Pharmacology/Toxicology; Phosphorylation; Piceatannol; Rats; Rats, Sprague-Dawley; Recovery of function; Reperfusion; Resveratrol; Signal transduction; Stilbenes - pharmacology; Stilbenes - therapeutic use; Transcription factors; PCT; SP6; Cerebral ischemia; c-Jun N-terminal kinase 3; Global ischemia; CBF

Cerebral ischemia is one of the leading causes of death and disability worldwide. The only FDA-approved treatment is recanalization with systemic tissue plasminogen activators like alteplase, although reperfusion caused by recanalization can result in neuroinflammation, which can cause brain cell ap...