Piceatannol improved cerebral blood flow and attenuated JNK3 and mitochondrial apoptotic pathway in a global ischemic model to produce neuroprotection
Cerebral ischemia is one of the leading causes of death and disability worldwide. The only FDA-approved treatment is recanalization with systemic tissue plasminogen activators like alteplase, although reperfusion caused by recanalization can result in neuroinflammation, which can cause brain cell ap...
Saved in:
Published in | Naunyn-Schmiedeberg's archives of pharmacology Vol. 397; no. 1; pp. 479 - 496 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
2024
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Cerebral ischemia is one of the leading causes of death and disability worldwide. The only FDA-approved treatment is recanalization with systemic tissue plasminogen activators like alteplase, although reperfusion caused by recanalization can result in neuroinflammation, which can cause brain cell apoptosis. Therefore, after an ischemic/reperfusion injury, interventions are needed to minimize the neuroinflammatory cascade. In the present study, piceatannol (PCT) was studied for its neuroprotective efficacy in a rat model of global ischemic injury by attenuating c-Jun N-terminal kinase 3 (JNK3) downstream signaling. PCT is a resveratrol analog and a polyphenolic stilbenoid naturally occurring in passion fruit and grapes. The neuroprotective efficacy of PCT (1, 5, 10 mg/kg) in ischemic conditions was assessed through pre- and post-treatment. Cerebral blood flow (CBF) and tests for functional recovery were assessed. Protein and gene expression were done for JNK3 and other inflammatory markers. A docking study was performed to identify the amino acid interaction. The results showed that PCT improved motor and memory function as measured by a functional recovery test believed to be due to an increase in cerebral blood flow. Also, the caspase signaling which promotes apoptosis was found to be down-regulated; however, nitric oxide synthase expression was up-regulated, which could explain the enhanced cerebral blood flow (CBF). According to our findings, PCT impeded c-Jun N-terminal kinase 3 (JNK3) signaling by suppressing phosphorylation and disrupting the mitochondrial apoptotic pathway, which resulted in the neuroprotective effect. Molecular docking analysis was performed to investigate the atomic-level interaction of JNK3 and PCT, which reveals that Met149, Leu206, and Lys93 amino acid residues are critical for the interaction of PCT and JNK3. According to our current research, JNK3 downstream signaling and the mitochondrial apoptosis pathway are both inhibited by PCT, which results in neuroprotection under conditions of global brain ischemia.
Graphical abstract
Piceatannol attenuated JNK3 phosphorylation during the ischemic condition and prevented neuronal apoptosis |
---|---|
AbstractList | Cerebral ischemia is one of the leading causes of death and disability worldwide. The only FDA-approved treatment is recanalization with systemic tissue plasminogen activators like alteplase, although reperfusion caused by recanalization can result in neuroinflammation, which can cause brain cell apoptosis. Therefore, after an ischemic/reperfusion injury, interventions are needed to minimize the neuroinflammatory cascade. In the present study, piceatannol (PCT) was studied for its neuroprotective efficacy in a rat model of global ischemic injury by attenuating c-Jun N-terminal kinase 3 (JNK3) downstream signaling. PCT is a resveratrol analog and a polyphenolic stilbenoid naturally occurring in passion fruit and grapes. The neuroprotective efficacy of PCT (1, 5, 10 mg/kg) in ischemic conditions was assessed through pre- and post-treatment. Cerebral blood flow (CBF) and tests for functional recovery were assessed. Protein and gene expression were done for JNK3 and other inflammatory markers. A docking study was performed to identify the amino acid interaction. The results showed that PCT improved motor and memory function as measured by a functional recovery test believed to be due to an increase in cerebral blood flow. Also, the caspase signaling which promotes apoptosis was found to be down-regulated; however, nitric oxide synthase expression was up-regulated, which could explain the enhanced cerebral blood flow (CBF). According to our findings, PCT impeded c-Jun N-terminal kinase 3 (JNK3) signaling by suppressing phosphorylation and disrupting the mitochondrial apoptotic pathway, which resulted in the neuroprotective effect. Molecular docking analysis was performed to investigate the atomic-level interaction of JNK3 and PCT, which reveals that Met149, Leu206, and Lys93 amino acid residues are critical for the interaction of PCT and JNK3. According to our current research, JNK3 downstream signaling and the mitochondrial apoptosis pathway are both inhibited by PCT, which results in neuroprotection under conditions of global brain ischemia. Piceatannol attenuated JNK3 phosphorylation during the ischemic condition and prevented neuronal apoptosis. Cerebral ischemia is one of the leading causes of death and disability worldwide. The only FDA-approved treatment is recanalization with systemic tissue plasminogen activators like alteplase, although reperfusion caused by recanalization can result in neuroinflammation, which can cause brain cell apoptosis. Therefore, after an ischemic/reperfusion injury, interventions are needed to minimize the neuroinflammatory cascade. In the present study, piceatannol (PCT) was studied for its neuroprotective efficacy in a rat model of global ischemic injury by attenuating c-Jun N-terminal kinase 3 (JNK3) downstream signaling. PCT is a resveratrol analog and a polyphenolic stilbenoid naturally occurring in passion fruit and grapes. The neuroprotective efficacy of PCT (1, 5, 10 mg/kg) in ischemic conditions was assessed through pre- and post-treatment. Cerebral blood flow (CBF) and tests for functional recovery were assessed. Protein and gene expression were done for JNK3 and other inflammatory markers. A docking study was performed to identify the amino acid interaction. The results showed that PCT improved motor and memory function as measured by a functional recovery test believed to be due to an increase in cerebral blood flow. Also, the caspase signaling which promotes apoptosis was found to be down-regulated; however, nitric oxide synthase expression was up-regulated, which could explain the enhanced cerebral blood flow (CBF). According to our findings, PCT impeded c-Jun N-terminal kinase 3 (JNK3) signaling by suppressing phosphorylation and disrupting the mitochondrial apoptotic pathway, which resulted in the neuroprotective effect. Molecular docking analysis was performed to investigate the atomic-level interaction of JNK3 and PCT, which reveals that Met149, Leu206, and Lys93 amino acid residues are critical for the interaction of PCT and JNK3. According to our current research, JNK3 downstream signaling and the mitochondrial apoptosis pathway are both inhibited by PCT, which results in neuroprotection under conditions of global brain ischemia.Piceatannol attenuated JNK3 phosphorylation during the ischemic condition and prevented neuronal apoptosis Cerebral ischemia is one of the leading causes of death and disability worldwide. The only FDA-approved treatment is recanalization with systemic tissue plasminogen activators like alteplase, although reperfusion caused by recanalization can result in neuroinflammation, which can cause brain cell apoptosis. Therefore, after an ischemic/reperfusion injury, interventions are needed to minimize the neuroinflammatory cascade. In the present study, piceatannol (PCT) was studied for its neuroprotective efficacy in a rat model of global ischemic injury by attenuating c-Jun N-terminal kinase 3 (JNK3) downstream signaling. PCT is a resveratrol analog and a polyphenolic stilbenoid naturally occurring in passion fruit and grapes. The neuroprotective efficacy of PCT (1, 5, 10 mg/kg) in ischemic conditions was assessed through pre- and post-treatment. Cerebral blood flow (CBF) and tests for functional recovery were assessed. Protein and gene expression were done for JNK3 and other inflammatory markers. A docking study was performed to identify the amino acid interaction. The results showed that PCT improved motor and memory function as measured by a functional recovery test believed to be due to an increase in cerebral blood flow. Also, the caspase signaling which promotes apoptosis was found to be down-regulated; however, nitric oxide synthase expression was up-regulated, which could explain the enhanced cerebral blood flow (CBF). According to our findings, PCT impeded c-Jun N-terminal kinase 3 (JNK3) signaling by suppressing phosphorylation and disrupting the mitochondrial apoptotic pathway, which resulted in the neuroprotective effect. Molecular docking analysis was performed to investigate the atomic-level interaction of JNK3 and PCT, which reveals that Met149, Leu206, and Lys93 amino acid residues are critical for the interaction of PCT and JNK3. According to our current research, JNK3 downstream signaling and the mitochondrial apoptosis pathway are both inhibited by PCT, which results in neuroprotection under conditions of global brain ischemia. Graphical abstract Piceatannol attenuated JNK3 phosphorylation during the ischemic condition and prevented neuronal apoptosis |
Author | Ramanathan, M. Kumar, Ram Pravin Rajan, Ravi Kumar |
Author_xml | – sequence: 1 givenname: Ravi Kumar surname: Rajan fullname: Rajan, Ravi Kumar email: ravi.rajan6@gmail.com organization: Department of Pharmacology, PSG College of Pharmacy, Department of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Science, Girijananda Chowdhury University – sequence: 2 givenname: Ram Pravin surname: Kumar fullname: Kumar, Ram Pravin organization: Department of Pharmacology, PSG College of Pharmacy – sequence: 3 givenname: M. surname: Ramanathan fullname: Ramanathan, M. organization: Department of Pharmacology, PSG College of Pharmacy |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37470802$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kbtuFTEQhi0URE4CL0CBLNHQLPi6lxJFQAIRUEBt-TLOcbRrL7aXKC_C82JyAkgUFJbl-b_5Z6z_BB3FFAGhp5S8pIQMrwohjJKOMN5OT_uOPEA7Kjjr6ETZEdo1fewom8ZjdFLKNSGkp1I-Qsd8EAMZCduhH5-DBV11jGnGYVlz-g4OW8hgsp6xmVNy2M_pBuvosK4V4qZrQ95__MDvakuoye5TdDm0Br2mtaYaLF513d_oWxwi1vhqTqapodg9LE1ckoMZ14TbQLdZwBG2nNqjgq0hxcfooddzgSf39yn6-vbNl7Pz7vLTu4uz15ed5YOsnZzMxA2FcRDGWjsY74Uxpn107J2XcvD9QKWYhKHMejeNxHk_SkOd0Vb2jJ-iFwffNvrbBqWqpe0I86wjpK0oNgrChBh73tDn_6DXacuxbafYRCkVktOpUexA2ZxKyeDVmsOi862iRP1KTR1SUy01dZeaIq3p2b31ZhZwf1p-x9QAfgBKk-IV5L-z_2P7E-U0pw0 |
CitedBy_id | crossref_primary_10_1007_s11030_024_10820_0 |
Cites_doi | 10.1073/pnas.2336254100 10.1007/s00044-013-0782-2 10.1007/s10822-020-00297-y 10.3389/fncel.2019.00074 10.1007/s11064-011-0687-8 10.3389/fphar.2019.01613 10.3389/fphar.2019.01216 10.1038/s41598-019-50946-y 10.1016/j.ejmech.2019.07.033 10.1038/s41538-021-00084-5 10.1126/science.275.5303.1129 10.1016/j.brainres.2004.11.050 10.1038/srep15967 10.1038/s41388-019-0734-5 10.1111/j.1755-5949.2008.00074.x 10.1038/srep34715 10.3390/nu10050530 10.1142/S0192415X22500884 10.1203/00006450-199004000-00001 10.1161/CIRCULATIONAHA.117.027448 10.1038/sj.jcbfm.9600062 10.1097/FBP.0000000000000256 10.1038/srep42323 10.1016/j.bmcl.2017.03.063 10.1016/j.crfs.2020.03.008 10.3390/ijms19030792 10.1038/s41467-019-11982-4 10.3389/fcell.2021.630678 10.1007/s10753-019-01125-8 10.1016/0304-3940(93)90343-J 10.1155/2020/5291852 10.1124/pr.108.000547 10.1039/C5FO01124H 10.3390/cells9102190 10.1074/jbc.M307888200 10.3390/ani10071239 10.1007/s10571-016-0412-x 10.1016/j.mrrev.2011.11.001 10.3389/fphar.2015.00321 10.1038/ncpcardio0046 10.1161/01.CIR.0000057973.99140.5A 10.1038/s41598-019-50954-y 10.1016/j.brainres.2006.03.086 10.1016/j.neuint.2018.01.007 10.1038/s41598-017-13912-0 10.1021/acs.jmedchem.9b00537 10.1038/srep03177 10.1038/s41598-019-47914-x 10.1016/j.brainres.2020.146798 10.1155/2012/459265 10.1186/s13020-021-00495-2 10.1038/s41580-019-0173-8 10.1111/j.1749-6632.2009.04727.x 10.1111/j.1365-2990.2009.01047.x 10.3389/fphar.2017.00735 10.4103/2045-9912.215750 10.1038/s41392-019-0075-4 10.3892/mmr.2017.6303 10.1038/s41598-017-18330-w 10.3390/nu9101142 10.1007/s00210-019-01673-8 10.1016/j.nbd.2004.09.014 10.1523/JNEUROSCI.1852-13.2013 10.3390/antiox9010016 10.2147/VHRM.S34874 10.1016/j.csbj.2020.06.013 10.1016/S1074-5521(03)00159-5 10.1016/B978-0-12-803058-5.00007-2 10.18632/oncotarget.13018 10.1016/B978-0-12-398456-2.00022-0 10.1007/978-1-4020-6554-5_3 10.1021/cn400094w 10.2147/NDT.S67184 |
ContentType | Journal Article |
Copyright | The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Copyright_xml | – notice: The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. – notice: 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7TK K9. 7X8 |
DOI | 10.1007/s00210-023-02616-0 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Calcium & Calcified Tissue Abstracts Neurosciences Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Health & Medical Complete (Alumni) Calcium & Calcified Tissue Abstracts Neurosciences Abstracts MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic ProQuest Health & Medical Complete (Alumni) MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Pharmacy, Therapeutics, & Pharmacology |
EISSN | 1432-1912 |
EndPage | 496 |
ExternalDocumentID | 10_1007_s00210_023_02616_0 37470802 |
Genre | Journal Article |
GroupedDBID | --- -4W -56 -5G -BR -EM -Y2 -~C .55 .86 .GJ .VR 06C 06D 0R~ 0VY 199 1N0 1SB 2.D 203 28- 29M 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 36B 3O- 3SX 3V. 4.4 406 408 409 40D 40E 53G 5QI 5RE 5VS 67N 67Z 6NX 78A 7X7 88E 8AO 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AABYN AAFGU AAHNG AAIAL AAJKR AANXM AANZL AARHV AARTL AATNV AATVU AAUYE AAWCG AAYFA AAYIU AAYQN AAYTO ABBBX ABBXA ABDZT ABECU ABELW ABFGW ABFTV ABHLI ABHQN ABJOX ABKAS ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACBMV ACBRV ACBXY ACBYP ACGFS ACHSB ACHXU ACIGE ACIPQ ACIWK ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACTTH ACVWB ACWMK ADBBV ADHHG ADHIR ADINQ ADKNI ADKPE ADMDM ADOAH ADOXG ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEEQQ AEFIE AEFTE AEGAL AEGNC AEJHL AEJRE AEKMD AENEX AEOHA AEPYU AEQTP AESKC AESTI AETLH AEVLU AEVTX AEXYK AFEXP AFGCZ AFKRA AFLOW AFNRJ AFQWF AFRAH AFWTZ AFZKB AGAYW AGDGC AGGBP AGGDS AGJBK AGMZJ AGQMX AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIIXL AILAN AIMYW AITGF AJBLW AJDOV AJRNO AJZVZ AKMHD AKQUC ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG AOSHJ ARMRJ AXYYD AZFZN B-. BA0 BBWZM BDATZ BENPR BGNMA BPHCQ BVXVI CAG CCPQU COF CSCUP DDRTE DL5 DNIVK DPUIP DU5 EBLON EBS EIOEI EJD EMB EMOBN EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GXS HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 I5X IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH L7B LAS LLZTM M1P M4Y MA- N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM P19 P2P PF0 PQQKQ PROAC PSQYO PT4 PT5 QOK QOR QOS R89 R9I RHV RIG RNI RNS ROL RPX RRX RSV RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TSG TSK TSV TUC U2A U9L UG4 UKHRP UNUBA UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK6 WK8 X7M YLTOR Z45 Z7U Z7W Z82 Z87 Z8O Z8Q Z8V Z91 ZGI ZMTXR ZOVNA ZXP ~EX AACDK AAEOY AAJBT AAQLM AASML AAYZH ABAKF ACAOD ACDTI ACZOJ AEFQL AEMSY AGQEE AGRTI AIGIU ALIPV CGR CUY CVF ECM EIF H13 NPM AAYXX CITATION 7QP 7TK K9. 7X8 |
ID | FETCH-LOGICAL-c375t-59b93b1e874bccc7bff4bbb00086df557f6715494b12cfd980dff85b1dbac5623 |
IEDL.DBID | AGYKE |
ISSN | 0028-1298 |
IngestDate | Sat Aug 17 01:52:05 EDT 2024 Thu Oct 10 22:07:54 EDT 2024 Thu Sep 12 18:17:30 EDT 2024 Wed Oct 16 00:08:57 EDT 2024 Sun Jan 07 01:23:06 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | PCT SP6 Cerebral ischemia c-Jun N-terminal kinase 3 Global ischemia CBF |
Language | English |
License | 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c375t-59b93b1e874bccc7bff4bbb00086df557f6715494b12cfd980dff85b1dbac5623 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 37470802 |
PQID | 2911145319 |
PQPubID | 2034514 |
PageCount | 18 |
ParticipantIDs | proquest_miscellaneous_2840244863 proquest_journals_2911145319 crossref_primary_10_1007_s00210_023_02616_0 pubmed_primary_37470802 springer_journals_10_1007_s00210_023_02616_0 |
PublicationCentury | 2000 |
PublicationDate | 1-2024 2024-Jan 2024-01-00 20240101 |
PublicationDateYYYYMMDD | 2024-01-01 |
PublicationDate_xml | – year: 2024 text: 1-2024 |
PublicationDecade | 2020 |
PublicationPlace | Berlin/Heidelberg |
PublicationPlace_xml | – name: Berlin/Heidelberg – name: Germany – name: Heidelberg |
PublicationTitle | Naunyn-Schmiedeberg's archives of pharmacology |
PublicationTitleAbbrev | Naunyn-Schmiedeberg's Arch Pharmacol |
PublicationTitleAlternate | Naunyn Schmiedebergs Arch Pharmacol |
PublicationYear | 2024 |
Publisher | Springer Berlin Heidelberg Springer Nature B.V |
Publisher_xml | – name: Springer Berlin Heidelberg – name: Springer Nature B.V |
References | Koizumi, Hirayama, Morizawa (CR34) 2018; 119 Peng, Yuan, Shi, Li, Song, Huang, Yi, Fu, Shen (CR41) 2020; 10 Kuan, Whitmarsh, Yang, Liao, Schloemer, Dong, Bao, Banasiak, Haddad, Flavell, Davis, Rakic (CR35) 2003; 100 Tsai, Huang, Kao, Chang, Cheng (CR59) 2022; 50 Shao, Xu, Zhou, Ge, Chen, Guo, Luo, Li, Zhu, Zhang (CR51) 2017; 37 Jung, Aman, Hah (CR30) 2017; 27 CR38 Sun, Tan, Yu (CR54) 2014; 2 Wahdan, Azab, Elsherbiny, El-Demerdash (CR61) 2019; 392 Dou, Huang, Li, Jiang, Wang, Jin, Jiao, Zhang, Zhang, Liu (CR17) 2019; 62 Bock, Tait (CR8) 2019 Bomfim, de Araujo, Dias, Sales, Rocha, Correa, Soares, Batista, Bezerra (CR9) 2019; 9 Chen, Mou, Feng, Wang, Chen (CR11) 2017; 7 Vannucci (CR60) 1990; 27 Xu, Yoshioka, Yoshimura, Tominaga, Nishioka, Ito, Nakabeppu (CR65) 2003; 278 Jia, Ji, Zhang, Chen, Wang (CR28) 2020; 10 Sehara, Sawicka, Hwang, Latuszek-Barrantes, Etgen, Zukin (CR50) 2013; 33 Dumont, Sanchez, Olivier, Chateil, Deffieux, Quideau, Pellerin, Beauvieux, Bouzier-Sore, Roumes (CR18) 2020; 1738 Ramanathan, Abdul, Justin (CR45) 2016; 27 Suzuki, Nakano, Mishiro, Takagi, Tsuruma, Nakamura, Yoshimura, Shimazawa, Hara (CR55) 2013; 3 Yang, Tongson, Kim, Park (CR69) 2020; 3 Joris, Mensink, Adam, Liu (CR29) 2018; 10 Liu, Zhao, Patzer, Staak, Boehm, Deuschl, Culman, Bonny, Herdegen, Eschenfelder (CR37) 2010; 36 Yamamoto, Kayama, Noguchi-Shinohara, Hamaguchi, Yamada, Abe, Kobayashi (CR66) 2021; 5 CR3 Hidalgo, Georgiev, Marchev, Bru-Martínez, Cusido, Corchete, Palazon (CR26) 2017; 7 Wang, Sun, Gao, Feng, Zhang, Hao, Zuo, Zhang, Li, Piao (CR62) 2016; 6 CR49 CR47 Dirnagl, Lindauer, Villringer (CR16) 1993; 149 Guan, Pei, Liu, Wang, Xu, Zhang (CR23) 2006; 1092 Musi, Agrò, Santarella, Iervasi, Borsello (CR39) 2020; 9 CR40 Khan, Khan, Ahmad, Ahmad, Rehman, Ikram, Kim (CR32) 2020; 2020 Bhuvanendran, Bakar, Kumari, Othman, Mohd, Hassan (CR6) 2019; 9 Guan, Pei, Zhang, Hao, Xu, Zhang (CR24) 2005; 1035 Yarza, Vela, Solas, Ramirez (CR70) 2016; 6 Wolters, Zonneveld, Hofman, van der Lugt, Koudstaal, Vernooij, Ikram (CR63) 2017; 136 Wu, Dai, Zhu, Li, Yuan, Wu, Miao, Zeng, Zhao (CR64) 2014; 23 Bastianetto, Dumont, Han, Quirion (CR4) 2009; 15 Kant, Craige, Chen, Reif, Learnard, Kelly, Caliz, Tran, Ramo, Peters, Freeman, Davis, Keaney (CR31) 2019; 10 Boccellino, Donniacuo, Bruno, Rinaldi, Quagliuolo, Ambruosi, Pace, De Rosa, Olgaç, Banoglu, Alessio, Massa, Kahn, Werz, Fiorentino, Filosa (CR7) 2019; 180 Takeshita, Yamamoto, Nozato, Inagaki, Tsuchimochi, Shirai, Yamamoto, Imaizumi, Hongyo, Yokoyama, Takeda, Oguro, Takami, Itoh, Takeya, Sugimoto, Fukada, Rakugi (CR56) 2017; 7 Kitada, Ogura, Maruki-Uchida, Sai, Suzuki, Kanasaki, Hara, Seto, Kuroshima, Monno, Koya (CR33) 2017; 9 Retinasamy, Shaikh, Kumari, Othman (CR46) 2019; 10 Cheng, Chiang, Kao, Huang (CR12) 2021; 16 Desgeorges, Devillard, Toutain, Castells, Divoux, Arnould, Haqq, Bernaudin, Durieux, Touzani, Freyssenet (CR15) 2017; 7 CR19 Rajan, Ramanathan (CR44) 2020; 34 Yang (CR68) 1997; 275 Zhu, Fang, Sun, Yang, Zhang, Yu, Yang (CR74) 2020; 43 CR14 CR13 CR10 CR52 Torres-Hernandez, Wang, Nikiforov, Tejada, Torres, Kalabin, Wu, Haq, Khan, Zhao, Su, Camargo, Hundeyin, Diskin, Adam, Rossi, Kurz, Aykut, Shadaloey, Miller (CR58) 2019; 38 Berger, Varriale, van Kessenich, Herrmann, de Arcangelis (CR5) 2019; 9 Salehpour, Farajdokht, Mahmoudi, Erfani, Farhoudi, Karimi, Rasta, Sadigh-Eteghad, Hamblin, Gjedde (CR48) 2019; 13 Abd El-Aal, Abd El-Fattah, El-Abhar (CR1) 2017; 8 Toda, Ayajiki, Okamura (CR57) 2009; 61 Yamasaki, Kawasaki, Nishina (CR67) 2012; 2012 Akinwumi, Bordun, Anderson (CR2) 2018; 19 Suhardja (CR53) 2004; 1 Jang, Kim, Kang, Lee, Lee (CR27) 2009; 1171 Gao, Signore, Yin, Cao, Yin, Sun, Luo, Graham, Chen (CR21) 2005; 25 He, Mo, Hu, Chen, Luo, Wu, Qiao, Xu, Zhou, Zuo, Deng, He, Wei (CR25) 2015; 5 Zhang, Li (CR71) 2012; 37 Lavi, Egbarya, Lavi, Jacob (CR36) 2003; 107 Zhang, Liu, Wang, Liu, Gu, Xu, Su (CR73) 2017; 15 Zhang, Liu, Jia, Ci, Zhang, Liu, Chen, Cao, Zhou (CR72) 2021; 9 Piotrowska, Kucinska, Murias (CR43) 2012; 750 Fu, Yang, Wei, Li (CR20) 2016; 7 Ghosh, Chakraborty, Sarkar, Bhowmik, Basu (CR22) 2019; 4 Pereira de Vasconcelos, Bouilleret, Riban, Wasterlain, Nehlig (CR42) 2005; 18 CA Musi (2616_CR39) 2020; 9 M Ramanathan (2616_CR45) 2016; 27 Y He (2616_CR25) 2015; 5 2616_CR3 FJ Bock (2616_CR8) 2019 2616_CR19 ZB Zhang (2616_CR71) 2012; 37 2616_CR14 F Salehpour (2616_CR48) 2019; 13 LM Bomfim (2616_CR9) 2019; 9 H Piotrowska (2616_CR43) 2012; 750 T Zhu (2616_CR74) 2020; 43 2616_CR13 2616_CR10 J-H Sun (2616_CR54) 2014; 2 2616_CR52 U Dumont (2616_CR18) 2020; 1738 M Kitada (2616_CR33) 2017; 9 Y-T Tsai (2616_CR59) 2022; 50 S Yamamoto (2616_CR66) 2021; 5 Z Chen (2616_CR11) 2017; 7 S Shao (2616_CR51) 2017; 37 SA Abd El-Aal (2616_CR1) 2017; 8 FJ Wolters (2616_CR63) 2017; 136 Q-H Guan (2616_CR24) 2005; 1035 2616_CR49 A Pereira de Vasconcelos (2616_CR42) 2005; 18 2616_CR47 Y Gao (2616_CR21) 2005; 25 D Hidalgo (2616_CR26) 2017; 7 MS Khan (2616_CR32) 2020; 2020 S Bhuvanendran (2616_CR6) 2019; 9 2616_CR40 L-Y Peng (2616_CR41) 2020; 10 T Retinasamy (2616_CR46) 2019; 10 Q-H Guan (2616_CR23) 2006; 1092 N Toda (2616_CR57) 2009; 61 X-X Wu (2616_CR64) 2014; 23 C-Y Cheng (2616_CR12) 2021; 16 S Bastianetto (2616_CR4) 2009; 15 J Yang (2616_CR68) 1997; 275 MK Ghosh (2616_CR22) 2019; 4 2616_CR38 A Torres-Hernandez (2616_CR58) 2019; 38 H Jung (2616_CR30) 2017; 27 H Takeshita (2616_CR56) 2017; 7 A Suhardja (2616_CR53) 2004; 1 S Koizumi (2616_CR34) 2018; 119 Q Wang (2616_CR62) 2016; 6 RK Rajan (2616_CR44) 2020; 34 T Yamasaki (2616_CR67) 2012; 2012 X Dou (2616_CR17) 2019; 62 S Lavi (2616_CR36) 2003; 107 YJ Jang (2616_CR27) 2009; 1171 P Joris (2616_CR29) 2018; 10 D Berger (2616_CR5) 2019; 9 S Zhang (2616_CR73) 2017; 15 Z Fu (2616_CR20) 2016; 7 JS Yang (2616_CR69) 2020; 3 C-Y Kuan (2616_CR35) 2003; 100 Y Sehara (2616_CR50) 2013; 33 Y Suzuki (2616_CR55) 2013; 3 M Boccellino (2616_CR7) 2019; 180 MM Desgeorges (2616_CR15) 2017; 7 U Dirnagl (2616_CR16) 1993; 149 RC Vannucci (2616_CR60) 1990; 27 S Kant (2616_CR31) 2019; 10 J-R Liu (2616_CR37) 2010; 36 P Jia (2616_CR28) 2020; 10 P Zhang (2616_CR72) 2021; 9 SA Wahdan (2616_CR61) 2019; 392 P Xu (2616_CR65) 2003; 278 R Yarza (2616_CR70) 2016; 6 B Akinwumi (2616_CR2) 2018; 19 |
References_xml | – volume: 100 start-page: 15184 issue: 25 year: 2003 end-page: 15189 ident: CR35 article-title: A critical role of neural-specific JNK3 for ischemic apoptosis publication-title: Proc Nat Acad Sci doi: 10.1073/pnas.2336254100 contributor: fullname: Rakic – volume: 23 start-page: 2456 issue: 5 year: 2014 end-page: 2475 ident: CR64 article-title: Molecular modeling studies of JNK3 inhibitors using QSAR and docking publication-title: Med Chem Res doi: 10.1007/s00044-013-0782-2 contributor: fullname: Zhao – volume: 34 start-page: 671 issue: 6 year: 2020 end-page: 682 ident: CR44 article-title: Identification and neuroprotective evaluation of a potential c-Jun N-terminal kinase 3 inhibitor through structure-based virtual screening and in-vitro assay publication-title: J Comput-Aided Mol Des doi: 10.1007/s10822-020-00297-y contributor: fullname: Ramanathan – ident: CR49 – volume: 13 start-page: 74 year: 2019 ident: CR48 article-title: Photobiomodulation and coenzyme Q10 treatments attenuate cognitive impairment associated with model of transient global brain ischemia in artificially aged mice publication-title: Front Cell Neurosci doi: 10.3389/fncel.2019.00074 contributor: fullname: Gjedde – volume: 37 start-page: 948 issue: 5 year: 2012 end-page: 957 ident: CR71 article-title: Cathepsin B and Phospo-JNK in relation to ongoing apoptosis after transient focal cerebral ischemia in the rat publication-title: Neurochem Res doi: 10.1007/s11064-011-0687-8 contributor: fullname: Li – volume: 10 start-page: 1613 year: 2020 ident: CR41 article-title: Protective effect of piceatannol against acute lung injury through protecting the integrity of air-blood barrier and modulating the TLR4/NF-κB signaling pathway activation publication-title: Front Pharmacol doi: 10.3389/fphar.2019.01613 contributor: fullname: Shen – volume: 10 start-page: 1216 year: 2019 ident: CR46 article-title: Ethanolic extract of Orthosiphon stamineus improves memory in scopolamine-induced amnesia model publication-title: Front Pharmacol doi: 10.3389/fphar.2019.01216 contributor: fullname: Othman – volume: 9 start-page: 15858 issue: 1 year: 2019 ident: CR5 article-title: Three cooperative mechanisms required for recovery after brain damage publication-title: Sci Rep doi: 10.1038/s41598-019-50946-y contributor: fullname: de Arcangelis – volume: 180 start-page: 637 year: 2019 end-page: 647 ident: CR7 article-title: Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors publication-title: Eur J Med Chem doi: 10.1016/j.ejmech.2019.07.033 contributor: fullname: Filosa – volume: 5 start-page: 1 issue: 1 year: 2021 ident: CR66 article-title: Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway publication-title: Npj Sci Food doi: 10.1038/s41538-021-00084-5 contributor: fullname: Kobayashi – volume: 275 start-page: 1129 issue: 5303 year: 1997 end-page: 32 ident: CR68 article-title: Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked publication-title: Science doi: 10.1126/science.275.5303.1129 contributor: fullname: Yang – volume: 1035 start-page: 51 issue: 1 year: 2005 end-page: 59 ident: CR24 article-title: The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways publication-title: Brain Res doi: 10.1016/j.brainres.2004.11.050 contributor: fullname: Zhang – volume: 5 start-page: 15967 issue: 1 year: 2015 ident: CR25 article-title: E adenophorum induces cell cycle arrest and apoptosis of splenocytes through the mitochondrial pathway and caspase activation in saanen goats publication-title: Sci Rep doi: 10.1038/srep15967 contributor: fullname: Wei – volume: 38 start-page: 4512 issue: 23 year: 2019 end-page: 4526 ident: CR58 article-title: Targeting SYK signaling in myeloid cells protects against liver fibrosis and hepatocarcinogenesis publication-title: Oncogene doi: 10.1038/s41388-019-0734-5 contributor: fullname: Miller – volume: 15 start-page: 76 issue: 1 year: 2009 end-page: 83 ident: CR4 article-title: Comparative neuroprotective properties of stilbene and catechin analogs: action via a plasma membrane receptor site? publication-title: CNS Neurosci Ther doi: 10.1111/j.1755-5949.2008.00074.x contributor: fullname: Quirion – volume: 6 start-page: 34715 issue: 1 year: 2016 ident: CR62 article-title: Bone marrow mesenchymal stem cells attenuate 2,5-hexanedione-induced neuronal apoptosis through a NGF/AKT-dependent pathway publication-title: Sci Rep doi: 10.1038/srep34715 contributor: fullname: Piao – volume: 10 start-page: 530 issue: 5 year: 2018 ident: CR29 article-title: Cerebral blood flow measurements in adults: a review on the effects of dietary factors and exercise publication-title: Nutrients doi: 10.3390/nu10050530 contributor: fullname: Liu – volume: 50 start-page: 2057 issue: 08 year: 2022 end-page: 2083 ident: CR59 article-title: Neuroprotective effects of Miq against mitochondria-related apoptosis by the interactions between upregulated p38 MAPK signaling and downregulated JNK signaling in the subacute phase of cerebral ischemia-reperfusion in rats publication-title: Am J Chin Med doi: 10.1142/S0192415X22500884 contributor: fullname: Cheng – volume: 27 start-page: 317 issue: 4 year: 1990 end-page: 326 ident: CR60 article-title: Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage publication-title: Pediatr Res doi: 10.1203/00006450-199004000-00001 contributor: fullname: Vannucci – volume: 136 start-page: 719 issue: 8 year: 2017 end-page: 728 ident: CR63 article-title: Cerebral perfusion and the risk of dementia: a population-based study publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.027448 contributor: fullname: Ikram – ident: CR19 – volume: 25 start-page: 694 issue: 6 year: 2005 end-page: 712 ident: CR21 article-title: Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway publication-title: J Cereb Blood Flow Metab doi: 10.1038/sj.jcbfm.9600062 contributor: fullname: Chen – volume: 27 start-page: 615 issue: 7 year: 2016 end-page: 622 ident: CR45 article-title: Low dose of L-glutamic acid attenuated the neurological dysfunctions and excitotoxicity in bilateral common carotid artery occluded mice publication-title: Behav Pharmacol doi: 10.1097/FBP.0000000000000256 contributor: fullname: Justin – volume: 7 start-page: 42323 issue: 1 year: 2017 ident: CR56 article-title: Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice publication-title: Sci Rep doi: 10.1038/srep42323 contributor: fullname: Rakugi – volume: 27 start-page: 2139 issue: 10 year: 2017 end-page: 2143 ident: CR30 article-title: Novel scaffold evolution through combinatorial 3D-QSAR model studies of two types of JNK3 inhibitors publication-title: Bioorganic Med Chem Lett doi: 10.1016/j.bmcl.2017.03.063 contributor: fullname: Hah – volume: 3 start-page: 92 year: 2020 end-page: 99 ident: CR69 article-title: Piceatannol attenuates fat accumulation and oxidative stress in steatosis-induced HepG2 cells publication-title: Curr Res Nutr Food Sci doi: 10.1016/j.crfs.2020.03.008 contributor: fullname: Park – volume: 19 start-page: 792 issue: 3 year: 2018 ident: CR2 article-title: Biological activities of stilbenoids publication-title: Int J Mol Sci doi: 10.3390/ijms19030792 contributor: fullname: Anderson – volume: 10 start-page: 4223 issue: 1 year: 2019 ident: CR31 article-title: Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis publication-title: Nat Com doi: 10.1038/s41467-019-11982-4 contributor: fullname: Keaney – volume: 9 start-page: 630678 year: 2021 ident: CR72 article-title: SP600125, a JNK-specific inhibitor, regulates in vitro auricular cartilage regeneration by promoting cell proliferation and inhibiting extracellular matrix metabolism publication-title: Front Cell Dev Biol doi: 10.3389/fcell.2021.630678 contributor: fullname: Zhou – volume: 43 start-page: 347 issue: 1 year: 2020 end-page: 357 ident: CR74 article-title: Piceatannol inhibits P. acnes–induced keratinocyte proliferation and migration by downregulating oxidative stress and the inflammatory response publication-title: Inflammation doi: 10.1007/s10753-019-01125-8 contributor: fullname: Yang – volume: 149 start-page: 43 issue: 1 year: 1993 end-page: 46 ident: CR16 article-title: Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats publication-title: Neurosci Lett doi: 10.1016/0304-3940(93)90343-J contributor: fullname: Villringer – volume: 2020 start-page: 1 year: 2020 end-page: 18 ident: CR32 article-title: Inhibition of JNK alleviates chronic hypoperfusion-related ischemia induces oxidative stress and brain degeneration via Nrf2/HO-1 and NF- B signaling publication-title: Oxid Med Cell Longev doi: 10.1155/2020/5291852 contributor: fullname: Kim – volume: 61 start-page: 62 issue: 1 year: 2009 end-page: 97 ident: CR57 article-title: Cerebral blood flow regulation by nitric oxide: recent advances publication-title: Pharmacol Rev doi: 10.1124/pr.108.000547 contributor: fullname: Okamura – volume: 7 start-page: 1014 issue: 2 year: 2016 end-page: 1023 ident: CR20 article-title: Effects of piceatannol and pterostilbene against β-amyloid-induced apoptosis on the PI3K/Akt/Bad signaling pathway in PC12 cells publication-title: Food & Funct doi: 10.1039/C5FO01124H contributor: fullname: Li – volume: 9 start-page: 2190 issue: 10 year: 2020 ident: CR39 article-title: JNK3 as therapeutic target and biomarker in neurodegenerative and neurodevelopmental brain diseases publication-title: Cells doi: 10.3390/cells9102190 contributor: fullname: Borsello – ident: CR47 – volume: 278 start-page: 48422 issue: 48 year: 2003 end-page: 48433 ident: CR65 article-title: development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis publication-title: J Biol Chem doi: 10.1074/jbc.M307888200 contributor: fullname: Nakabeppu – ident: CR14 – volume: 10 start-page: 1239 issue: 7 year: 2020 ident: CR28 article-title: Piceatannol ameliorates hepatic oxidative damage and mitochondrial dysfunction of weaned piglets challenged with Diquat publication-title: Animals doi: 10.3390/ani10071239 contributor: fullname: Wang – volume: 37 start-page: 753 issue: 4 year: 2017 end-page: 762 ident: CR51 article-title: Atorvastatin attenuates ischemia/reperfusion-induced hippocampal neurons injury via Akt-nNOS-JNK signaling pathway publication-title: Cell Mol Neurobiol doi: 10.1007/s10571-016-0412-x contributor: fullname: Zhang – volume: 750 start-page: 60 issue: 1 year: 2012 end-page: 82 ident: CR43 article-title: Biological activity of piceatannol: leaving the shadow of resveratrol publication-title: Mutat Res Rev Mutat Res doi: 10.1016/j.mrrev.2011.11.001 contributor: fullname: Murias – volume: 2 start-page: 16 issue: 8 year: 2014 ident: CR54 article-title: Post-stroke cognitive impairment: epidemiology, mechanisms and management publication-title: Ann Transl Med contributor: fullname: Yu – ident: CR10 – volume: 6 start-page: 321 year: 2016 ident: CR70 article-title: C-Jun N-terminal kinase (JNK) signaling as a therapeutic target for Alzheimer’s disease publication-title: Front Pharmacol doi: 10.3389/fphar.2015.00321 contributor: fullname: Ramirez – volume: 1 start-page: 110 issue: 2 year: 2004 end-page: 116 ident: CR53 article-title: Mechanisms of disease: roles of nitric oxide and endothelin-1 in delayed cerebral vasospasm produced by aneurysmal subarachnoid hemorrhage publication-title: Nat Clin Pract Cardiovasc Med doi: 10.1038/ncpcardio0046 contributor: fullname: Suhardja – volume: 107 start-page: 1901 issue: 14 year: 2003 end-page: 1905 ident: CR36 article-title: Role of nitric oxide in the regulation of cerebral blood flow in humans: chemoregulation versus mechanoregulation publication-title: Circulation doi: 10.1161/01.CIR.0000057973.99140.5A contributor: fullname: Jacob – volume: 9 start-page: 14507 issue: 1 year: 2019 ident: CR6 article-title: Embelin improves the spatial memory and hippocampal long-term potentiation in a rat model of chronic cerebral hypoperfusion publication-title: Sci Rep doi: 10.1038/s41598-019-50954-y contributor: fullname: Hassan – volume: 1092 start-page: 36 issue: 1 year: 2006 end-page: 46 ident: CR23 article-title: Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis publication-title: Brain Res doi: 10.1016/j.brainres.2006.03.086 contributor: fullname: Zhang – volume: 119 start-page: 107 year: 2018 end-page: 114 ident: CR34 article-title: New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia publication-title: Neurochem Int doi: 10.1016/j.neuint.2018.01.007 contributor: fullname: Morizawa – volume: 7 start-page: 14000 issue: 1 year: 2017 ident: CR15 article-title: Pharmacological inhibition of myostatin improves skeletal muscle mass and function in a mouse model of stroke publication-title: Sci Rep doi: 10.1038/s41598-017-13912-0 contributor: fullname: Freyssenet – volume: 62 start-page: 6645 issue: 14 year: 2019 end-page: 6664 ident: CR17 article-title: Multistage screening reveals 3-substituted indolin-2-one derivatives as novel and isoform-selective c-Jun N-terminal kinase 3 (JNK3) inhibitors: implications to drug discovery for potential treatment of neurodegenerative diseases publication-title: J Med Chem doi: 10.1021/acs.jmedchem.9b00537 contributor: fullname: Liu – ident: CR40 – volume: 3 start-page: 3177 issue: 1 year: 2013 ident: CR55 article-title: Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke publication-title: Sci Rep doi: 10.1038/srep03177 contributor: fullname: Hara – volume: 9 start-page: 11483 issue: 1 year: 2019 ident: CR9 article-title: Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell proliferation, cause DNA double-strand break and trigger caspase-mediated apoptosis through JNK/p38 pathways in human acute promyelocytic leukemia cells publication-title: Sci Rep doi: 10.1038/s41598-019-47914-x contributor: fullname: Bezerra – volume: 1738 start-page: 146798 year: 2020 ident: CR18 article-title: Maternal alcoholism and neonatal hypoxia-ischemia: neuroprotection by stilbenoid polyphenols publication-title: Brain Research doi: 10.1016/j.brainres.2020.146798 contributor: fullname: Roumes – volume: 2012 start-page: 1 year: 2012 end-page: 9 ident: CR67 article-title: Diverse roles of JNK and MKK pathways in the brain publication-title: J Sig Trans doi: 10.1155/2012/459265 contributor: fullname: Nishina – volume: 16 start-page: 82 issue: 1 year: 2021 ident: CR12 article-title: Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats publication-title: Chin Med doi: 10.1186/s13020-021-00495-2 contributor: fullname: Huang – year: 2019 ident: CR8 article-title: Mitochondria as multifaceted regulators of cell death publication-title: Nat Rev Mol Cell Biol doi: 10.1038/s41580-019-0173-8 contributor: fullname: Tait – volume: 1171 start-page: 176 issue: 1 year: 2009 end-page: 182 ident: CR27 article-title: Piceatannol attenuates 4-hydroxynonenal-induced apoptosis of PC12 cells by blocking activation of c-Jun N-terminal kinase publication-title: Annals New York Acad Sci doi: 10.1111/j.1749-6632.2009.04727.x contributor: fullname: Lee – volume: 36 start-page: 211 issue: 3 year: 2010 end-page: 224 ident: CR37 article-title: The c-Jun N-terminal kinase (JNK) inhibitor XG-102 enhances the neuroprotection of hyperbaric oxygen after cerebral ischaemia in adult rats publication-title: Neuropathol Appl Neurobiol doi: 10.1111/j.1365-2990.2009.01047.x contributor: fullname: Eschenfelder – ident: CR3 – ident: CR38 – volume: 8 start-page: 735 year: 2017 ident: CR1 article-title: CoQ10 augments rosuvastatin neuroprotective effect in a model of global ischemia via inhibition of NF-κB/JNK3/Bax and activation of Akt/FOXO3A/Bim cues publication-title: Front Pharmacol doi: 10.3389/fphar.2017.00735 contributor: fullname: El-Abhar – ident: CR52 – volume: 7 start-page: 194 issue: 3 year: 2017 ident: CR11 article-title: The role of nitric oxide in stroke publication-title: Med Gas Res doi: 10.4103/2045-9912.215750 contributor: fullname: Chen – ident: CR13 – volume: 4 start-page: 42 issue: 1 year: 2019 ident: CR22 article-title: The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports publication-title: Sig Transduct Target Ther doi: 10.1038/s41392-019-0075-4 contributor: fullname: Basu – volume: 15 start-page: 2595 issue: 5 year: 2017 end-page: 2603 ident: CR73 article-title: PAR1-mediated c-Jun activation promotes heat stress-induced early stage apoptosis of human umbilical vein endothelial cells publication-title: Mol Med Rep doi: 10.3892/mmr.2017.6303 contributor: fullname: Su – volume: 7 start-page: 17976 issue: 1 year: 2017 ident: CR26 article-title: Tailoring tobacco hairy root metabolism for the production of stilbenes publication-title: Sci Rep doi: 10.1038/s41598-017-18330-w contributor: fullname: Palazon – volume: 9 start-page: 1142 issue: 10 year: 2017 ident: CR33 article-title: The effect of piceatannol from passion fruit (Passiflora edulis) seeds on metabolic health in humans publication-title: Nutrients doi: 10.3390/nu9101142 contributor: fullname: Koya – volume: 392 start-page: 1331 issue: 11 year: 2019 end-page: 1345 ident: CR61 article-title: Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade publication-title: Naunyn Schmiedebergs Arch Pharmacol doi: 10.1007/s00210-019-01673-8 contributor: fullname: El-Demerdash – volume: 18 start-page: 270 issue: 2 year: 2005 end-page: 281 ident: CR42 article-title: Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2004.09.014 contributor: fullname: Nehlig – volume: 33 start-page: 12364 issue: 30 year: 2013 end-page: 12374 ident: CR50 article-title: Survivin is a transcriptional target of STAT3 critical to estradiol neuroprotection in global ischemia publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1852-13.2013 contributor: fullname: Zukin – volume: 9 start-page: 630678 year: 2021 ident: 2616_CR72 publication-title: Front Cell Dev Biol doi: 10.3389/fcell.2021.630678 contributor: fullname: P Zhang – volume: 15 start-page: 76 issue: 1 year: 2009 ident: 2616_CR4 publication-title: CNS Neurosci Ther doi: 10.1111/j.1755-5949.2008.00074.x contributor: fullname: S Bastianetto – volume: 107 start-page: 1901 issue: 14 year: 2003 ident: 2616_CR36 publication-title: Circulation doi: 10.1161/01.CIR.0000057973.99140.5A contributor: fullname: S Lavi – volume: 62 start-page: 6645 issue: 14 year: 2019 ident: 2616_CR17 publication-title: J Med Chem doi: 10.1021/acs.jmedchem.9b00537 contributor: fullname: X Dou – volume: 16 start-page: 82 issue: 1 year: 2021 ident: 2616_CR12 publication-title: Chin Med doi: 10.1186/s13020-021-00495-2 contributor: fullname: C-Y Cheng – volume: 7 start-page: 194 issue: 3 year: 2017 ident: 2616_CR11 publication-title: Med Gas Res doi: 10.4103/2045-9912.215750 contributor: fullname: Z Chen – volume: 61 start-page: 62 issue: 1 year: 2009 ident: 2616_CR57 publication-title: Pharmacol Rev doi: 10.1124/pr.108.000547 contributor: fullname: N Toda – volume: 1171 start-page: 176 issue: 1 year: 2009 ident: 2616_CR27 publication-title: Annals New York Acad Sci doi: 10.1111/j.1749-6632.2009.04727.x contributor: fullname: YJ Jang – volume: 50 start-page: 2057 issue: 08 year: 2022 ident: 2616_CR59 publication-title: Am J Chin Med doi: 10.1142/S0192415X22500884 contributor: fullname: Y-T Tsai – volume: 27 start-page: 2139 issue: 10 year: 2017 ident: 2616_CR30 publication-title: Bioorganic Med Chem Lett doi: 10.1016/j.bmcl.2017.03.063 contributor: fullname: H Jung – volume: 2012 start-page: 1 year: 2012 ident: 2616_CR67 publication-title: J Sig Trans doi: 10.1155/2012/459265 contributor: fullname: T Yamasaki – ident: 2616_CR13 doi: 10.3390/antiox9010016 – volume: 25 start-page: 694 issue: 6 year: 2005 ident: 2616_CR21 publication-title: J Cereb Blood Flow Metab doi: 10.1038/sj.jcbfm.9600062 contributor: fullname: Y Gao – volume: 7 start-page: 17976 issue: 1 year: 2017 ident: 2616_CR26 publication-title: Sci Rep doi: 10.1038/s41598-017-18330-w contributor: fullname: D Hidalgo – volume: 10 start-page: 1239 issue: 7 year: 2020 ident: 2616_CR28 publication-title: Animals doi: 10.3390/ani10071239 contributor: fullname: P Jia – volume: 100 start-page: 15184 issue: 25 year: 2003 ident: 2616_CR35 publication-title: Proc Nat Acad Sci doi: 10.1073/pnas.2336254100 contributor: fullname: C-Y Kuan – volume: 13 start-page: 74 year: 2019 ident: 2616_CR48 publication-title: Front Cell Neurosci doi: 10.3389/fncel.2019.00074 contributor: fullname: F Salehpour – volume: 6 start-page: 321 year: 2016 ident: 2616_CR70 publication-title: Front Pharmacol doi: 10.3389/fphar.2015.00321 contributor: fullname: R Yarza – ident: 2616_CR47 doi: 10.2147/VHRM.S34874 – ident: 2616_CR19 doi: 10.1016/j.csbj.2020.06.013 – year: 2019 ident: 2616_CR8 publication-title: Nat Rev Mol Cell Biol doi: 10.1038/s41580-019-0173-8 contributor: fullname: FJ Bock – volume: 34 start-page: 671 issue: 6 year: 2020 ident: 2616_CR44 publication-title: J Comput-Aided Mol Des doi: 10.1007/s10822-020-00297-y contributor: fullname: RK Rajan – ident: 2616_CR49 doi: 10.1016/S1074-5521(03)00159-5 – volume: 5 start-page: 1 issue: 1 year: 2021 ident: 2616_CR66 publication-title: Npj Sci Food doi: 10.1038/s41538-021-00084-5 contributor: fullname: S Yamamoto – volume: 37 start-page: 948 issue: 5 year: 2012 ident: 2616_CR71 publication-title: Neurochem Res doi: 10.1007/s11064-011-0687-8 contributor: fullname: ZB Zhang – ident: 2616_CR14 doi: 10.1016/B978-0-12-803058-5.00007-2 – volume: 10 start-page: 4223 issue: 1 year: 2019 ident: 2616_CR31 publication-title: Nat Com doi: 10.1038/s41467-019-11982-4 contributor: fullname: S Kant – volume: 10 start-page: 1216 year: 2019 ident: 2616_CR46 publication-title: Front Pharmacol doi: 10.3389/fphar.2019.01216 contributor: fullname: T Retinasamy – volume: 37 start-page: 753 issue: 4 year: 2017 ident: 2616_CR51 publication-title: Cell Mol Neurobiol doi: 10.1007/s10571-016-0412-x contributor: fullname: S Shao – volume: 33 start-page: 12364 issue: 30 year: 2013 ident: 2616_CR50 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1852-13.2013 contributor: fullname: Y Sehara – ident: 2616_CR40 doi: 10.18632/oncotarget.13018 – volume: 2020 start-page: 1 year: 2020 ident: 2616_CR32 publication-title: Oxid Med Cell Longev doi: 10.1155/2020/5291852 contributor: fullname: MS Khan – volume: 2 start-page: 16 issue: 8 year: 2014 ident: 2616_CR54 publication-title: Ann Transl Med contributor: fullname: J-H Sun – volume: 9 start-page: 1142 issue: 10 year: 2017 ident: 2616_CR33 publication-title: Nutrients doi: 10.3390/nu9101142 contributor: fullname: M Kitada – volume: 38 start-page: 4512 issue: 23 year: 2019 ident: 2616_CR58 publication-title: Oncogene doi: 10.1038/s41388-019-0734-5 contributor: fullname: A Torres-Hernandez – volume: 27 start-page: 317 issue: 4 year: 1990 ident: 2616_CR60 publication-title: Pediatr Res doi: 10.1203/00006450-199004000-00001 contributor: fullname: RC Vannucci – volume: 7 start-page: 42323 issue: 1 year: 2017 ident: 2616_CR56 publication-title: Sci Rep doi: 10.1038/srep42323 contributor: fullname: H Takeshita – volume: 149 start-page: 43 issue: 1 year: 1993 ident: 2616_CR16 publication-title: Neurosci Lett doi: 10.1016/0304-3940(93)90343-J contributor: fullname: U Dirnagl – ident: 2616_CR38 doi: 10.1016/B978-0-12-398456-2.00022-0 – volume: 1738 start-page: 146798 year: 2020 ident: 2616_CR18 publication-title: Brain Research doi: 10.1016/j.brainres.2020.146798 contributor: fullname: U Dumont – ident: 2616_CR10 doi: 10.1007/978-1-4020-6554-5_3 – volume: 43 start-page: 347 issue: 1 year: 2020 ident: 2616_CR74 publication-title: Inflammation doi: 10.1007/s10753-019-01125-8 contributor: fullname: T Zhu – volume: 10 start-page: 530 issue: 5 year: 2018 ident: 2616_CR29 publication-title: Nutrients doi: 10.3390/nu10050530 contributor: fullname: P Joris – volume: 10 start-page: 1613 year: 2020 ident: 2616_CR41 publication-title: Front Pharmacol doi: 10.3389/fphar.2019.01613 contributor: fullname: L-Y Peng – volume: 7 start-page: 14000 issue: 1 year: 2017 ident: 2616_CR15 publication-title: Sci Rep doi: 10.1038/s41598-017-13912-0 contributor: fullname: MM Desgeorges – volume: 1 start-page: 110 issue: 2 year: 2004 ident: 2616_CR53 publication-title: Nat Clin Pract Cardiovasc Med doi: 10.1038/ncpcardio0046 contributor: fullname: A Suhardja – volume: 5 start-page: 15967 issue: 1 year: 2015 ident: 2616_CR25 publication-title: Sci Rep doi: 10.1038/srep15967 contributor: fullname: Y He – volume: 136 start-page: 719 issue: 8 year: 2017 ident: 2616_CR63 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.027448 contributor: fullname: FJ Wolters – volume: 119 start-page: 107 year: 2018 ident: 2616_CR34 publication-title: Neurochem Int doi: 10.1016/j.neuint.2018.01.007 contributor: fullname: S Koizumi – volume: 27 start-page: 615 issue: 7 year: 2016 ident: 2616_CR45 publication-title: Behav Pharmacol doi: 10.1097/FBP.0000000000000256 contributor: fullname: M Ramanathan – volume: 23 start-page: 2456 issue: 5 year: 2014 ident: 2616_CR64 publication-title: Med Chem Res doi: 10.1007/s00044-013-0782-2 contributor: fullname: X-X Wu – volume: 3 start-page: 3177 issue: 1 year: 2013 ident: 2616_CR55 publication-title: Sci Rep doi: 10.1038/srep03177 contributor: fullname: Y Suzuki – volume: 9 start-page: 15858 issue: 1 year: 2019 ident: 2616_CR5 publication-title: Sci Rep doi: 10.1038/s41598-019-50946-y contributor: fullname: D Berger – volume: 9 start-page: 14507 issue: 1 year: 2019 ident: 2616_CR6 publication-title: Sci Rep doi: 10.1038/s41598-019-50954-y contributor: fullname: S Bhuvanendran – volume: 1092 start-page: 36 issue: 1 year: 2006 ident: 2616_CR23 publication-title: Brain Res doi: 10.1016/j.brainres.2006.03.086 contributor: fullname: Q-H Guan – ident: 2616_CR52 doi: 10.1021/cn400094w – volume: 392 start-page: 1331 issue: 11 year: 2019 ident: 2616_CR61 publication-title: Naunyn Schmiedebergs Arch Pharmacol doi: 10.1007/s00210-019-01673-8 contributor: fullname: SA Wahdan – volume: 15 start-page: 2595 issue: 5 year: 2017 ident: 2616_CR73 publication-title: Mol Med Rep doi: 10.3892/mmr.2017.6303 contributor: fullname: S Zhang – ident: 2616_CR3 doi: 10.2147/NDT.S67184 – volume: 275 start-page: 1129 issue: 5303 year: 1997 ident: 2616_CR68 publication-title: Science doi: 10.1126/science.275.5303.1129 contributor: fullname: J Yang – volume: 18 start-page: 270 issue: 2 year: 2005 ident: 2616_CR42 publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2004.09.014 contributor: fullname: A Pereira de Vasconcelos – volume: 750 start-page: 60 issue: 1 year: 2012 ident: 2616_CR43 publication-title: Mutat Res Rev Mutat Res doi: 10.1016/j.mrrev.2011.11.001 contributor: fullname: H Piotrowska – volume: 8 start-page: 735 year: 2017 ident: 2616_CR1 publication-title: Front Pharmacol doi: 10.3389/fphar.2017.00735 contributor: fullname: SA Abd El-Aal – volume: 9 start-page: 2190 issue: 10 year: 2020 ident: 2616_CR39 publication-title: Cells doi: 10.3390/cells9102190 contributor: fullname: CA Musi – volume: 19 start-page: 792 issue: 3 year: 2018 ident: 2616_CR2 publication-title: Int J Mol Sci doi: 10.3390/ijms19030792 contributor: fullname: B Akinwumi – volume: 7 start-page: 1014 issue: 2 year: 2016 ident: 2616_CR20 publication-title: Food & Funct doi: 10.1039/C5FO01124H contributor: fullname: Z Fu – volume: 1035 start-page: 51 issue: 1 year: 2005 ident: 2616_CR24 publication-title: Brain Res doi: 10.1016/j.brainres.2004.11.050 contributor: fullname: Q-H Guan – volume: 9 start-page: 11483 issue: 1 year: 2019 ident: 2616_CR9 publication-title: Sci Rep doi: 10.1038/s41598-019-47914-x contributor: fullname: LM Bomfim – volume: 4 start-page: 42 issue: 1 year: 2019 ident: 2616_CR22 publication-title: Sig Transduct Target Ther doi: 10.1038/s41392-019-0075-4 contributor: fullname: MK Ghosh – volume: 180 start-page: 637 year: 2019 ident: 2616_CR7 publication-title: Eur J Med Chem doi: 10.1016/j.ejmech.2019.07.033 contributor: fullname: M Boccellino – volume: 6 start-page: 34715 issue: 1 year: 2016 ident: 2616_CR62 publication-title: Sci Rep doi: 10.1038/srep34715 contributor: fullname: Q Wang – volume: 36 start-page: 211 issue: 3 year: 2010 ident: 2616_CR37 publication-title: Neuropathol Appl Neurobiol doi: 10.1111/j.1365-2990.2009.01047.x contributor: fullname: J-R Liu – volume: 278 start-page: 48422 issue: 48 year: 2003 ident: 2616_CR65 publication-title: J Biol Chem doi: 10.1074/jbc.M307888200 contributor: fullname: P Xu – volume: 3 start-page: 92 year: 2020 ident: 2616_CR69 publication-title: Curr Res Nutr Food Sci doi: 10.1016/j.crfs.2020.03.008 contributor: fullname: JS Yang |
SSID | ssj0006155 |
Score | 2.4455314 |
Snippet | Cerebral ischemia is one of the leading causes of death and disability worldwide. The only FDA-approved treatment is recanalization with systemic tissue... |
SourceID | proquest crossref pubmed springer |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 479 |
SubjectTerms | Amino acids Amino Acids - pharmacology Animals Apoptosis Biomedical and Life Sciences Biomedicine Blood flow Brain Ischemia - metabolism c-Jun protein Caspase Cerebral blood flow Cerebrovascular Circulation Gene expression Inflammation Ischemia JNK Mitogen-Activated Protein Kinases JNK protein JNK3 protein Kinases Mitochondria Mitogen-Activated Protein Kinase 10 - metabolism Molecular Docking Simulation Neuroprotection Neurosciences Nitric-oxide synthase Pharmacology/Toxicology Phosphorylation Piceatannol Rats Rats, Sprague-Dawley Recovery of function Reperfusion Resveratrol Signal transduction Stilbenes - pharmacology Stilbenes - therapeutic use Transcription factors |
Title | Piceatannol improved cerebral blood flow and attenuated JNK3 and mitochondrial apoptotic pathway in a global ischemic model to produce neuroprotection |
URI | https://link.springer.com/article/10.1007/s00210-023-02616-0 https://www.ncbi.nlm.nih.gov/pubmed/37470802 https://www.proquest.com/docview/2911145319 https://search.proquest.com/docview/2840244863 |
Volume | 397 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9tAEB4a59JL06aPqE3DFEoutYKl1ctHU_IgocEHG9KT2CeYuiuTyAT3h_T3dnb1MMXtIRcdpGV3xbx3Zr4F-EwuNmO5yUJF5iNMDJOhiOlBMU-cj0TOIuMO9L_dZlfz5Pouvdv2cfti9y4j6RV13-vmo5OQTEzowgYKg_dgP3WAXwPYn1x-vznvFbBLtXXgy2TOirZX5t-z_G2PdpzMnQSptzsXBzDruneacpMfZ-tanMlfu2COT_mll_Ci9UNx0jDOK3im7SGcThsg680QZ9u-rIchnuJ0C3G9eQ2_p6RfOPmVtlriwp9LaIVS37s09BJ9NTyaZfWI3Cp0EJ52TU6twuvbG-bf_SRNQprXKicAyFfVqq5oLXQ3JD_yDS4scmzQSnBBEbir4Ud_bQ_WFa48Tq1Gj8bZQk0Qg72B-cX57OtV2N7wEEqWp3WYjsWYiUgXeSKklLkwJhGiCbSUSVNiotxhyCUiiqVR42KkjClSESnBpfPc3sLAVlYfATLONc80H7FCJjKmaXSusjiOVCR1znkAXzo6l6sGyKPsIZs9IUoiROkJUY4COO5YoWyF-qGMnWFInNIK4FP_mcTR5Vi41dWaxlDATB5TkbEA3jUs1C_HKHRzrc0BDDt-2E7-_728f9rwD_A8pi00x0THMKjv1_ojOU61OGkF5QT25vHkD1VSESE |
link.rule.ids | 315,786,790,27955,27956,41114,41556,42183,42625,52144,52267 |
linkProvider | Springer Nature |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9NAEB5BeoBLebeGAoOEeiGuYq9fOVaoJTRtlEMilZO1Tyki2FHjqAo_hN_L7PoRQeHQiw_2anetee_MfAvwkVxsxlKT-IrMhx8ZJn0R0oNinjAdiJQFxh7oX02S0Ty6uI6vm6awdVvt3qYknabumt1ceOKTjfFt3EBx8EPYi6yF78He6Zdv47NOA9tcW4u-TPYsa5pl_j3Lnwbpjpd5J0PqDM_5E5i3W67rTb6fbCpxIn_-heZ43396CvuNJ4qnNes8gwe6eA7H0xrKetvH2a4za93HY5zuQK63L-DXlDQMJ8-yKJe4cCcTWqHUNzYRvURXD49mWd4iLxRaEM9iQ26twovJmLl3P0iXkO4tlBUB5KtyVZW0Fto7km_5FhcFcqzxSnBBMbit4kd3cQ9WJa4cUq1Gh8fZgE0Qi72E-fnZ7PPIb-548CVL48qPh2LIRKCzNBJSylQYEwlRh1rKxDGxUWpR5CIRhNKoYTZQxmSxCJTg0vpur6BXlIU-BGSca55oPmCZjGRI0-hUJWEYqEDqlHMPPrWEzlc1lEfegTY7QuREiNwRIh94cNTyQt6I9ToPrWmIrNry4EP3mQTSZll4ocsNjaGQmXymLGEeHNQ81C3HKHizzc0e9Ft-2E3-_728vt_w9_BoNLu6zC-_TsZv4HFI26kPjY6gV91s9FtyoyrxrpGa3-55FAw |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB5BkRAXxJtAgUFCvbBRN3Zee6yAVWlhtYeu1Fvkp7TS4kRtVtX-EX4vY-exoMKBSw6JZUf67JlvPJ7PAB-IYnNe2DzW5D7i1HIVS0YPinlYMZUFT6zf0P--yE9X6dlldvlbFX847T6kJLuaBq_S5NrjRtvjsfAthCox-ZvYxxAUE9-Fe941-jm-YiejLfZZt0GHmTxb2ZfN_L2PP13TLb55K1caXND8ETzsuSOedGA_hjvGPYGjZSc-vZvgxb6W6nqCR7jcy1LvnsLPJdkEQVzQ1Rtch70Eo1GZK5863mA4wY52U9-gcBq97KbbEhHVeLY45-HdD1r9ZC2d9pMWRVM3bU1job_V-EbscO1QYKcwgmuKmv25ewxX7WBbYxO0ZQ0GBc1eHoImxTNYzb9cfDqN-1sZYsWLrI2zmZxxmZiySKVSqpDWplJ2wZG2WUbAF173LZUJU1bPyqm2tsxkoqVQnm09hwNXO_MSkAthRG7ElJcqVYy6MYXOGUt0okwhRAQfB0CqphPfqEaZ5QBfRfBVAb5qGsHhgFnVL8TrinljnnpDE8H78TMtIZ8XEc7UW2pDQS6xnDLnEbzosB6H4xRu-XLkCCYD-PvO__0vr_6v-Tu4v_w8r759XZy_hgeM_qbb5TmEg_Zqa94Q72nl2zC1fwEdUftj |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Piceatannol+improved+cerebral+blood+flow+and+attenuated+JNK3+and+mitochondrial+apoptotic+pathway+in+a+global+ischemic+model+to+produce+neuroprotection&rft.jtitle=Naunyn-Schmiedeberg%27s+archives+of+pharmacology&rft.au=Rajan%2C+Ravi+Kumar&rft.au=Kumar%2C+Ram+Pravin&rft.au=Ramanathan%2C+M.&rft.date=2024-01-01&rft.pub=Springer+Berlin+Heidelberg&rft.issn=0028-1298&rft.eissn=1432-1912&rft.volume=397&rft.issue=1&rft.spage=479&rft.epage=496&rft_id=info:doi/10.1007%2Fs00210-023-02616-0&rft.externalDocID=10_1007_s00210_023_02616_0 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-1298&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-1298&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-1298&client=summon |