Prostaglandin A2 Interacts with Nurr1 and Ameliorates Behavioral Deficits in Parkinson’s Disease Fly Model

• Published in: Neuromolecular medicine Vol. 24; no. 4; pp. 469 - 478
• Main Authors: Rajan, Sreekanth, Toh, Hui Ting, Ye, Hong, Wang, Ziyin, Basil, Adeline Henry, Parnaik, Tanvi, Yoo, Jun Yeob, Lim, Kah-Leong, Yoon, Ho Sup
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2022; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Crystal structure; Degeneration; Dopamine; Dopamine receptors; Internal Medicine; Kinases; Ligands; LRRK2 protein; Medicine; Mesencephalon; Movement disorders; Neurodegeneration; Neurodegenerative diseases; Neurology; Neurosciences; NMR; Nuclear magnetic resonance; Nuclear receptors; Nurr1 protein; Original Paper; Parkinson's disease; Plasmids; Prostaglandin E2; Prostaglandins; Proteins; Titration; Transcription activation; NR4A2; Nuclear receptor; Parkinson's disease; LRRK2; Drosophila; Nurr1; Prostaglandin A2

The orphan nuclear receptor Nurr1 is critical for the development, maintenance, and protection of midbrain dopaminergic neurons. Recently, we demonstrated that prostaglandins E1 (PGE1) and PGA1 directly bind to the ligand-binding domain (LBD) of Nurr1 and stimulate its transcriptional activation fun...