Bupropion Ameliorates Acetic Acid–Induced Colitis in Rat: the Involvement of the TLR4/NF-kB Signaling Pathway

• Published in: Inflammation Vol. 43; no. 5; pp. 1999 - 2009
• Main Authors: Rashidian, Amir, Dejban, Pegah, Karami Fard, Kiana, Abdollahi, Alireza, Chamanara, Mohsen, Dehpour, Ahmadreza, Hasanvand, Amin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2020; Springer Nature B.V
• Subjects: Acetic acid; Acids; Animal models; Anti-inflammatory agents; Biomedical and Life Sciences; Biomedicine; Bupropion; Crohn's disease; Dexamethasone; Gastrointestinal tract; Immunology; Inflammatory bowel disease; Inflammatory bowel diseases; Internal Medicine; Intestine; Lesions; NF-κB protein; Oral administration; Original Article; Pathology; Pharmacology/Toxicology; Rheumatology; Rodents; Signal transduction; TLR4 protein; Toll-like receptors; Tumor necrosis factor-α; Ulcerative colitis; TLR4/NF-kB signaling pathway; bupropion; inflammatory bowel disease; acetic acid

Inflammatory bowel disease composed of ulcerative colitis and Crohn’s disease is a disorder that may involve entire gastrointestinal tract. Its pathogenesis is mainly an immune-mediated inflammation. Recently, it has been indicated that bupropion possesses anti-inflammatory properties; hence, the ob...