Comparison of selegiline and levodopa combination therapy versus levodopa monotherapy in the treatment of Parkinson’s disease: a meta-analysis

• Published in: Aging clinical and experimental research Vol. 32; no. 5; pp. 769 - 779
• Main Authors: Jiang, De-Qi, Li, Ming-Xing, Jiang, Li-Lin, Chen, Xiao-Bai, Zhou, Xing-Wen
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2020; Springer Nature B.V
• Subjects: Activities of Daily Living; Aging; Combination therapy; Combined Modality Therapy; Dopamine; Drug dosages; Drug Therapy, Combination; Geriatrics/Gerontology; Humans; Levodopa - therapeutic use; Medicine; Medicine & Public Health; Mental Status and Dementia Tests; Meta-analysis; Mortality; Parkinson Disease - drug therapy; Parkinson's disease; Pharmacy; Quality; Review; Selegiline - therapeutic use; Studies; Treatment Outcome; Selegiline; UPDRS; Levodopa; Safety; Parkinson’s disease; Meta-analysis
• ISSN: 1720-8319; 1594-0667; 1720-8319
• DOI: 10.1007/s40520-019-01232-4

Background Selegiline or levodopa treatment has been suggested as a therapeutic method for Parkinson’s disease (PD) in many clinical trial reports. However, the combined effects of two drugs still remain controversial. The aim of this report was to evaluate the clinical efficacy and safety of selegi...