Clinical Utility of Genomic Profiling Tests in Patients with Advanced Gastrointestinal Cancers

• Published in: Targeted oncology Vol. 17; no. 2; pp. 177 - 185
• Main Authors: Takeda, Hiroyuki, Imoto, Kiyomi, Umemoto, Kumiko, Doi, Ayako, Arai, Hiroyuki, Horie, Yoshiki, Mizukami, Takuro, Oguri, Tomoyo, Ogura, Takashi, Izawa, Naoki, Yamamoto, Hiroyuki, Yamano, Yoshihisa, Sunakawa, Yu
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2022; Springer Nature B.V
• Subjects: Biomarkers, Tumor - genetics; Biomedicine; Brain cancer; Cancer therapies; Gastrointestinal cancer; Gastrointestinal Neoplasms - genetics; Genes; Humans; Medical prognosis; Medicine; Medicine & Public Health; Mutation; Oncology; Original Research Article; Patients; Proto-Oncogene Proteins B-raf - genetics; Retrospective Studies; Software

Background Comprehensive analyses of cancer-related genomic alterations are expected to lead to increased availability of targeted therapies. However, in patients with gastrointestinal (GI) cancers, the utility of genomic profiling is unclear because of common non-druggable alterations and rapid dis...