Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization

• Published in: Journal of pharmacokinetics and pharmacodynamics Vol. 46; no. 5; pp. 411 - 426
• Main Authors: McEneny-King, Alanna, Chelle, Pierre, Foster, Gary, Keepanasseril, Arun, Iorio, Alfonso, Edginton, Andrea N.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2019; Springer Nature B.V
• Subjects: Adolescent; Adult; Bayesian analysis; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Child; Child, Preschool; Coagulation factors; Drug Dosage Calculations; Factor VIII - pharmacokinetics; Factor VIII - therapeutic use; Factor VIII deficiency; Fat-free body mass; Hemophilia; Hemophilia A - drug therapy; Humans; Infant; Middle Aged; Models, Biological; Original Paper; Pharmacokinetics; Pharmacology/Toxicology; Pharmacy; Precision Medicine - statistics & numerical data; Prophylaxis; Veterinary Medicine/Veterinary Science; Young Adult; Population pharmacokinetics; Dose individualization; Bayesian forecasting; Hemophilia

Hemophilia A is a rare bleeding disorder resulting from a lack of functional factor VIII (FVIII). Therapy consists of replacement with exogenous FVIII, but is complicated by high inter-patient variability. A population pharmacokinetics (PopPK) approach can facilitate the uptake of an individualized...