Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization - McEneny-King, Alanna; Chelle, Pierre; Foster, Gary; Keepanasseril, Arun; Iorio, Alfonso; Edginton, Andrea N. (Journal of pharmacokinetics and pharmacodynamics, 2019)
Keywords: Adolescent; Adult; Bayesian analysis; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Child; Child, Preschool; Coagulation factors; Drug Dosage Calculations; Factor VIII - pharmacokinetics; Factor VIII - therapeutic use; Factor VIII deficiency; Fat-free body mass; Hemophilia; Hemophilia A - drug therapy; Humans; Infant; Middle Aged; Models, Biological; Original Paper; Pharmacokinetics; Pharmacology/Toxicology; Pharmacy; Precision Medicine - statistics & numerical data; Prophylaxis; Veterinary Medicine/Veterinary Science; Young Adult; Population pharmacokinetics; Dose individualization; Bayesian forecasting; Hemophilia