Recent developments on production, purification and biological activity of marine peptides
[Display omitted] •Both Asia and Europe contributed largely to marine peptide research.•Combined processing technologies improved marine peptides yield and bioactivity.•Various biological activities shown by marine peptides were overviewed.•Amino acid sequence and structure determine the bioactivity...
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Published in | Food research international Vol. 147; p. 110468 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.09.2021
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Subjects | |
Online Access | Get full text |
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Abstract | [Display omitted]
•Both Asia and Europe contributed largely to marine peptide research.•Combined processing technologies improved marine peptides yield and bioactivity.•Various biological activities shown by marine peptides were overviewed.•Amino acid sequence and structure determine the bioactivity of peptides.•Novel methods are needed to enhance bioavailability of the marine peptides.
Marine peptides are one of the richest sources of structurally diverse bioactive compounds and a considerable attention has been drawn towards their production and bioactivity. However, there is a paucity in consolidation of emerging trends encompassing both production techniques and biological application. Herein, we intend to review the recent advancements on different production, purification and identification technologies used for marine peptides along with presenting their potential health benefits. Bibliometric analysis revealed a growing number of scientific publications on marine peptides (268 documents per year) with both Asia (37.2%) and Europe (33.1%) being the major contributors. Extraction and purification by ultrafiltration and enzymatic hydrolysis, followed by identification by chromatographic techniques coupled with an appropriate detector could yield a high content of peptides with improved bioactivity. Moreover, the multifunctional health benefits exerted by marine peptides including anti-microbial, antioxidant, anti-hypertension, anti-diabetes and anti-cancer along with their structure–activity relationship were presented. The future perspective on marine peptide research should focus on finding improved separation and purification technologies with enhanced selectivity and resolution for obtaining more novel peptides with high yield and low cost. In addition, by employing encapsulation strategies such as nanoemulsion and nanoliposome, oral bioavailability and bioactivity of peptides can be greatly enhanced. Also, the potential health benefits that are demonstrated by in vitro and in vivo models should be validated by conducting human clinical trials for a technology transfer from bench to bedside. |
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AbstractList | Marine peptides are one of the richest sources of structurally diverse bioactive compounds and a considerable attention has been drawn towards their production and bioactivity. However, there is a paucity in consolidation of emerging trends encompassing both production techniques and biological application. Herein, we intend to review the recent advancements on different production, purification and identification technologies used for marine peptides along with presenting their potential health benefits. Bibliometric analysis revealed a growing number of scientific publications on marine peptides (268 documents per year) with both Asia (37.2%) and Europe (33.1%) being the major contributors. Extraction and purification by ultrafiltration and enzymatic hydrolysis, followed by identification by chromatographic techniques coupled with an appropriate detector could yield a high content of peptides with improved bioactivity. Moreover, the multifunctional health benefits exerted by marine peptides including anti-microbial, antioxidant, anti-hypertension, anti-diabetes and anti-cancer along with their structure–activity relationship were presented. The future perspective on marine peptide research should focus on finding improved separation and purification technologies with enhanced selectivity and resolution for obtaining more novel peptides with high yield and low cost. In addition, by employing encapsulation strategies such as nanoemulsion and nanoliposome, oral bioavailability and bioactivity of peptides can be greatly enhanced. Also, the potential health benefits that are demonstrated by in vitro and in vivo models should be validated by conducting human clinical trials for a technology transfer from bench to bedside. Marine peptides are one of the richest sources of structurally diverse bioactive compounds and a considerable attention has been drawn towards their production and bioactivity. However, there is a paucity in consolidation of emerging trends encompassing both production techniques and biological application. Herein, we intend to review the recent advancements on different production, purification and identification technologies used for marine peptides along with presenting their potential health benefits. Bibliometric analysis revealed a growing number of scientific publications on marine peptides (268 documents per year) with both Asia (37.2%) and Europe (33.1%) being the major contributors. Extraction and purification by ultrafiltration and enzymatic hydrolysis, followed by identification by chromatographic techniques coupled with an appropriate detector could yield a high content of peptides with improved bioactivity. Moreover, the multifunctional health benefits exerted by marine peptides including anti-microbial, antioxidant, anti-hypertension, anti-diabetes and anti-cancer along with their structure-activity relationship were presented. The future perspective on marine peptide research should focus on finding improved separation and purification technologies with enhanced selectivity and resolution for obtaining more novel peptides with high yield and low cost. In addition, by employing encapsulation strategies such as nanoemulsion and nanoliposome, oral bioavailability and bioactivity of peptides can be greatly enhanced. Also, the potential health benefits that are demonstrated by in vitro and in vivo models should be validated by conducting human clinical trials for a technology transfer from bench to bedside.Marine peptides are one of the richest sources of structurally diverse bioactive compounds and a considerable attention has been drawn towards their production and bioactivity. However, there is a paucity in consolidation of emerging trends encompassing both production techniques and biological application. Herein, we intend to review the recent advancements on different production, purification and identification technologies used for marine peptides along with presenting their potential health benefits. Bibliometric analysis revealed a growing number of scientific publications on marine peptides (268 documents per year) with both Asia (37.2%) and Europe (33.1%) being the major contributors. Extraction and purification by ultrafiltration and enzymatic hydrolysis, followed by identification by chromatographic techniques coupled with an appropriate detector could yield a high content of peptides with improved bioactivity. Moreover, the multifunctional health benefits exerted by marine peptides including anti-microbial, antioxidant, anti-hypertension, anti-diabetes and anti-cancer along with their structure-activity relationship were presented. The future perspective on marine peptide research should focus on finding improved separation and purification technologies with enhanced selectivity and resolution for obtaining more novel peptides with high yield and low cost. In addition, by employing encapsulation strategies such as nanoemulsion and nanoliposome, oral bioavailability and bioactivity of peptides can be greatly enhanced. Also, the potential health benefits that are demonstrated by in vitro and in vivo models should be validated by conducting human clinical trials for a technology transfer from bench to bedside. [Display omitted] •Both Asia and Europe contributed largely to marine peptide research.•Combined processing technologies improved marine peptides yield and bioactivity.•Various biological activities shown by marine peptides were overviewed.•Amino acid sequence and structure determine the bioactivity of peptides.•Novel methods are needed to enhance bioavailability of the marine peptides. Marine peptides are one of the richest sources of structurally diverse bioactive compounds and a considerable attention has been drawn towards their production and bioactivity. However, there is a paucity in consolidation of emerging trends encompassing both production techniques and biological application. Herein, we intend to review the recent advancements on different production, purification and identification technologies used for marine peptides along with presenting their potential health benefits. Bibliometric analysis revealed a growing number of scientific publications on marine peptides (268 documents per year) with both Asia (37.2%) and Europe (33.1%) being the major contributors. Extraction and purification by ultrafiltration and enzymatic hydrolysis, followed by identification by chromatographic techniques coupled with an appropriate detector could yield a high content of peptides with improved bioactivity. Moreover, the multifunctional health benefits exerted by marine peptides including anti-microbial, antioxidant, anti-hypertension, anti-diabetes and anti-cancer along with their structure–activity relationship were presented. The future perspective on marine peptide research should focus on finding improved separation and purification technologies with enhanced selectivity and resolution for obtaining more novel peptides with high yield and low cost. In addition, by employing encapsulation strategies such as nanoemulsion and nanoliposome, oral bioavailability and bioactivity of peptides can be greatly enhanced. Also, the potential health benefits that are demonstrated by in vitro and in vivo models should be validated by conducting human clinical trials for a technology transfer from bench to bedside. |
ArticleNumber | 110468 |
Author | Inbaraj, Baskaran Stephen Sridhar, Kandi Chen, Bing-Huei |
Author_xml | – sequence: 1 givenname: Kandi surname: Sridhar fullname: Sridhar, Kandi – sequence: 2 givenname: Baskaran Stephen surname: Inbaraj fullname: Inbaraj, Baskaran Stephen – sequence: 3 givenname: Bing-Huei surname: Chen fullname: Chen, Bing-Huei email: 002622@mail.fju.edu.tw |
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Keywords | UPLC/MS DPP-IV EDC Enzymatic hydrolysis MALDI-MS MTT HHP LC-MS/MS Ultrafiltration DW RPLC BW IC50 UHPLC HILIC HPLC FPLC SBP CE ACE GLP-1 DPPH MALDI-TOF Chronic disease IEC MS IGD ESI-MS FAB-MS SOD MW Chromatography CE-MS/MS LC-ESI-MS/MS PEF RP-HPLC SEC SDS-PAGE LC-MS MWCO DES MAO-A DNA Marine bioactives ROS GRAS Multifunctional peptides Q-TOF MS |
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•Both Asia and Europe contributed largely to marine peptide research.•Combined processing technologies improved marine peptides yield and... Marine peptides are one of the richest sources of structurally diverse bioactive compounds and a considerable attention has been drawn towards their production... |
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SubjectTerms | antioxidants Asia bibliometric analysis bioactive properties bioavailability Chromatography Chronic disease encapsulation Enzymatic hydrolysis Europe food research humans Marine bioactives Multifunctional peptides nanoemulsions peptides structure-activity relationships technology transfer Ultrafiltration |
Title | Recent developments on production, purification and biological activity of marine peptides |
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