Targeted protein degradation combined with PET imaging reveals the role of host PD-L1 in determining anti-PD-1 therapy efficacy - Du, Jinhong; Han, Shu; Zhou, Haoyi; Wang, Jianze; Wang, Feng; Zhao, Meixin; Song, Rui; Li, Kui; Zhu, Hua; Zhang, Weifang; Yang, Zhi; Liu, Zhaofei (European journal of nuclear medicine and molecular imaging, 2024)
Keywords: Animal models; Animals; Antitumor activity; Apoptosis; Asialoglycoprotein Receptor - metabolism; B7-H1 Antigen - metabolism; Biopsy; Cardiology; Cell culture; Cell death; Cell Line, Tumor; Chimeras; Degradation; Dendritic cells; Hepatocytes; Humans; Imaging; In vivo methods and tests; Liver cancer; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Lysosomes; Lysosomes - metabolism; Macrophages; Medical imaging; Medicine; Medicine & Public Health; Mice; Microenvironments; Nuclear Medicine; Oncology; Original Article; Orthopedics; PD-1 protein; PD-L1 protein; Positron emission; Positron emission tomography; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Programmed Cell Death 1 Receptor - metabolism; Proteins; Proteolysis - drug effects; Radioactive tracers; Radiology; Therapy; Treatment Outcome; Tumor cells; Zirconium isotopes; LYTAC; Protein degradation; Immune checkpoint; Programmed death-ligand 1; Positron emission tomography