Remote ischemic preconditioning protects against cerebral ischemia injury in rats by upregulating miR-204-5p and activating the PINK1/Parkin signaling pathway

• Published in: Metabolic brain disease Vol. 37; no. 4; pp. 945 - 959
• Main Authors: Jiao, Yiming, Wang, Jinlan, Jia, Yanjie, Xue, Mengzhou
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2022; Springer Nature B.V
• Subjects: Animals; Apoptosis; Autophagy; Biochemistry; Biomedical and Life Sciences; Biomedicine; Brain damage; Brain injury; Brain Ischemia - genetics; Brain Ischemia - metabolism; Brain Ischemia - prevention & control; Cerebral blood flow; Cerebral infarction; Cytokines; Deprivation; Infarction, Middle Cerebral Artery - metabolism; Inflammation; Injury prevention; Ischemia; Ischemic Preconditioning; Metabolic Diseases; MicroRNAs - genetics; MicroRNAs - metabolism; Neurological diseases; Neurology; Neurosciences; Nuclear Proteins - metabolism; Occlusion; Oncology; Organs; Original Article; Parkin protein; Preconditioning; Protein Kinases - metabolism; PTEN-induced putative kinase; Rats; Rats, Sprague-Dawley; Reperfusion Injury - metabolism; Signal Transduction; Transcription Factors; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; PINK1; Signaling pathway; Cerebral ischemia injury; miR-204-5p; Remote ischemic preconditioning; Autophagy; BRD4; Parkin

Remote ischemic preconditioning (RiPC) is the process where preconditioning ischemia protects the organs against the subsequent index ischemia. RiPC is a protective method for brain damage. This study is to explore the effect and mechanism of RiPC in cerebral ischemia injury in rats through regulati...