Cholesterol Induces Epithelial-to-Mesenchymal Transition of Prostate Cancer Cells by Suppressing Degradation of EGFR through APMAP

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 12; pp. 3063 - 3075
• Main Authors: Jiang, Siyuan, Wang, Xuetong, Song, Dalong, Liu, XiaoJun, Gu, Yinmin, Xu, Zhiyuan, Wang, Xiaodong, Zhang, Xiaolu, Ye, Qinong, Tong, Zhou, Yan, BingXue, Yu, Jie, Chen, Yunzhao, Sun, Minxuan, Wang, Yang, Gao, Shan
• Format: Journal Article
• Language: English
• Published: United States 15.06.2019
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animals; Apoptosis; Case-Control Studies; Cell Proliferation; Cholesterol - pharmacology; Epithelial-Mesenchymal Transition - drug effects; ErbB Receptors - genetics; ErbB Receptors - metabolism; Gene Expression Regulation, Neoplastic - drug effects; Humans; Male; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Mice; Mice, Inbred NOD; Mice, SCID; Prognosis; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Proteolysis - drug effects; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Cholesterol increases the risk of aggressive prostate cancer and has emerged as a potential therapeutic target for prostate cancer. The functional roles of cholesterol in prostate cancer metastasis are not fully understood. Here, we found that cholesterol induces the epithelial-to-mesenchymal transi...