Potential value of circulatory microRNA122 gene expression as a prognostic and metastatic prediction marker for breast cancer

• Published in: Molecular biology reports Vol. 46; no. 3; pp. 2809 - 2818
• Main Authors: Saleh, Amany A., Soliman, Shimaa E., Habib, Mona Salah El-din, Gohar, Suzy F., Abo-Zeid, Ghada S.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.06.2019; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Animal Anatomy; Animal Biochemistry; Biomarkers; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biomedical and Life Sciences; Breast cancer; Breast Neoplasms - blood; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Carcinoembryonic antigen; Case-Control Studies; Circulating MicroRNA - blood; Circulating MicroRNA - genetics; Disease-Free Survival; Enzyme-linked immunosorbent assay; Female; Gene Expression; Histology; Humans; Kaplan-Meier Estimate; Life Sciences; Metastases; Metastasis; MicroRNAs - blood; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miRNA; Morphology; Neoplasm Metastasis; Neoplasm Staging; Original Article; Prognosis; Survival; Survival analysis; Breast cancer; MicroRNA; Metastasis; miR-122; RT-PCR

Despite progress in terms of management, breast cancer still constitutes a major threat to health worldwide. Various microRNAs have been shown to play a fundamental role in tumor biology during development and progression. Therefore, our study was focused on investigating the role of circulating mic...