LY3022855, an anti–colony stimulating factor-1 receptor (CSF-1R) monoclonal antibody, in patients with advanced solid tumors refractory to standard therapy: phase 1 dose-escalation trial

• Published in: Investigational new drugs Vol. 39; no. 4; pp. 1057 - 1071
• Main Authors: Dowlati, Afshin, Harvey, R. Donald, Carvajal, Richard D., Hamid, Omid, Klempner, Samuel J., Kauh, John Sae Wook, Peterson, Daniel A., Yu, Danni, Chapman, Sonya C., Szpurka, Anna M., Carlsen, Michelle, Quinlan, Tonya, Wesolowski, Robert
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2021; Springer Nature B.V
• Subjects: Administration, Intravenous; Adolescent; Adult; Adverse events; Aged; Anemia; Anorexia; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Antineoplastic Agents - pharmacokinetics; Cohort Studies; Colonies; Colony-stimulating factor; Diarrhea; Dosage; Dose-Response Relationship, Drug; Female; Fever; Heart; Humans; Immunogenicity; Immunotherapy; Intravenous administration; L-Lactate dehydrogenase; Lactate dehydrogenase; Lactic acid; Macrophage colony-stimulating factor; Macrophages; Male; Mathematical analysis; Medicine; Medicine & Public Health; Metastases; Middle Aged; Monoclonal antibodies; Nausea; Neoplasms - drug therapy; Oncology; Pancreatitis; Patients; Pharmacodynamics; Pharmacokinetics; Pharmacology; Pharmacology/Toxicology; Phase I Studies; Receptors; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors; Resistance factors; Rhabdomyolysis; Solid tumors; Toxicity; Tumors; Ventricle; Vomiting; Weight; Young Adult; Advanced solid tumor; Immunotherapy; LY3022855; CSF-1; IL-34; Tumor -associated macrophages; CSF-1R inhibitor

Summary Background Tumor-associated macrophages (TAMs) promote tumor growth, metastasis, and therapeutic resistance via colony-stimulating factor-1 (CSF-1), acting through CSF-1 receptor (CSF-1R) signaling. This phase 1 study determined the safety, tolerability, pharmacokinetics-pharmacodynamics, im...