Spironolactone improves left atrial function and atrioventricular coupling in patients with resistant hypertension

• Published in: The international journal of cardiovascular imaging Vol. 40; no. 3; pp. 487 - 497
• Main Authors: Girard, Andrew A., Denney, Thomas S., Gupta, Himanshu, Dell’Italia, Louis J., Calhoun, David A., Oparil, Suzanne, Sharifov, Oleg F., Lloyd, Steven G.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.03.2024; Springer Nature B.V
• Subjects: Aldosterone; Antihypertensives; Blood pressure; Cardiac Imaging; Cardiology; Coupling; Hypertension; Imaging; Magnetic resonance imaging; Medicine; Medicine & Public Health; Mineralocorticoid receptors; Original Paper; Pressure effects; Radiology; Renin; Left atrioventricular coupling index; Left atrial function; Left atrial strain; Cardiovascular magnetic resonance; Resistant hypertension; Left atrial structure

To determine the blood pressure independent effects of spironolactone on left atrial (LA) size and function in patients with resistant hypertension (RHTN). Patients with RHTN (n = 36, mean age 55 ± 7) were prospectively recruited. Spironolactone was initiated at 25 mg/day and increased to 50 mg/day...