Multiscale pharmacokinetic modeling of systemic exposure of subcutaneously injected biotherapeutics

• Published in: Journal of controlled release Vol. 337; pp. 407 - 416
• Main Authors: Zheng, Fudan, Hou, Peng, Corpstein, Clairissa D., Park, Kinam, Li, Tonglei
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 10.09.2021
• Subjects: absorption; albumins; Bioavailability; biomechanics; Biotherapeutics; catabolism; lymph; mAb; Multiscale modeling; pharmacokinetics; Physiologically-based pharmacokinetics; Simulation; skin (animal); Subcutaneous absorption; Bioavailability; Multiscale modeling; ECM; mAb; Physiologically-based pharmacokinetics; SC; CDR; Biotherapeutics; Simulation; NMSE; mAbs; FcRn; PK; Subcutaneous absorption; TMDD; mPBPK

Subcutaneously injected formulations have been developed for many biological products including monoclonal antibodies (mAbs). A knowledge gap nonetheless remains regarding the absorption and catabolism mechanisms and kinetics of a large molecule at the administration site. A multiscale pharmacokinet...