Exploring metabolic and inflammatory abnormalities in rheumatoid arthritis patients developing stroke disease: a case-control study using electronic medical record data in northern China
Objectives Intend to investigate the roles of serum lipids, inflammatory markers, and serological status in rheumatoid arthritis and stroke patients by using case-control study. Materials and methods Clinical data were retrieved from the electronic medical record of the First Affiliated Hospital of...
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Published in | Clinical rheumatology Vol. 38; no. 5; pp. 1401 - 1411 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Springer London
01.05.2019
Springer Nature B.V |
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Abstract | Objectives
Intend to investigate the roles of serum lipids, inflammatory markers, and serological status in rheumatoid arthritis and stroke patients by using case-control study.
Materials and methods
Clinical data were retrieved from the electronic medical record of the First Affiliated Hospital of China Medical University during January 2011 to March 2018. The obtained data were categorized into case groups and three control groups, in the ratios of 1:2, respectively, with all matching age and gender. Multinomial logistic regression analysis and restricted cubic spline were conducted examining the associations between serum lipids, inflammatory markers, serological status, and the risk of stroke among RA patients.
Results
The present studies included 1057 study subjects. The elevated ESR, LDL-C levels, and much higher CRP levels ≥ 230 mg/L were independent risk factors for RA patients in developing stroke. Furthermore, we found that ESR and LDL-C levels could exhibit a linear association with the risk of comorbid stroke while CRP level had a nonlinearity association with stroke risk among RA patients.
Conclusions
A close monitoring is required for RA patients with dyslipidemia and elevated inflammatory markers, and the primary stroke preventive strategies should be directed against these risk factors. |
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AbstractList | Intend to investigate the roles of serum lipids, inflammatory markers, and serological status in rheumatoid arthritis and stroke patients by using case-control study.
Clinical data were retrieved from the electronic medical record of the First Affiliated Hospital of China Medical University during January 2011 to March 2018. The obtained data were categorized into case groups and three control groups, in the ratios of 1:2, respectively, with all matching age and gender. Multinomial logistic regression analysis and restricted cubic spline were conducted examining the associations between serum lipids, inflammatory markers, serological status, and the risk of stroke among RA patients.
The present studies included 1057 study subjects. The elevated ESR, LDL-C levels, and much higher CRP levels ≥ 230 mg/L were independent risk factors for RA patients in developing stroke. Furthermore, we found that ESR and LDL-C levels could exhibit a linear association with the risk of comorbid stroke while CRP level had a nonlinearity association with stroke risk among RA patients.
A close monitoring is required for RA patients with dyslipidemia and elevated inflammatory markers, and the primary stroke preventive strategies should be directed against these risk factors. ObjectivesIntend to investigate the roles of serum lipids, inflammatory markers, and serological status in rheumatoid arthritis and stroke patients by using case-control study.Materials and methodsClinical data were retrieved from the electronic medical record of the First Affiliated Hospital of China Medical University during January 2011 to March 2018. The obtained data were categorized into case groups and three control groups, in the ratios of 1:2, respectively, with all matching age and gender. Multinomial logistic regression analysis and restricted cubic spline were conducted examining the associations between serum lipids, inflammatory markers, serological status, and the risk of stroke among RA patients.ResultsThe present studies included 1057 study subjects. The elevated ESR, LDL-C levels, and much higher CRP levels ≥ 230 mg/L were independent risk factors for RA patients in developing stroke. Furthermore, we found that ESR and LDL-C levels could exhibit a linear association with the risk of comorbid stroke while CRP level had a nonlinearity association with stroke risk among RA patients.ConclusionsA close monitoring is required for RA patients with dyslipidemia and elevated inflammatory markers, and the primary stroke preventive strategies should be directed against these risk factors. Objectives Intend to investigate the roles of serum lipids, inflammatory markers, and serological status in rheumatoid arthritis and stroke patients by using case-control study. Materials and methods Clinical data were retrieved from the electronic medical record of the First Affiliated Hospital of China Medical University during January 2011 to March 2018. The obtained data were categorized into case groups and three control groups, in the ratios of 1:2, respectively, with all matching age and gender. Multinomial logistic regression analysis and restricted cubic spline were conducted examining the associations between serum lipids, inflammatory markers, serological status, and the risk of stroke among RA patients. Results The present studies included 1057 study subjects. The elevated ESR, LDL-C levels, and much higher CRP levels ≥ 230 mg/L were independent risk factors for RA patients in developing stroke. Furthermore, we found that ESR and LDL-C levels could exhibit a linear association with the risk of comorbid stroke while CRP level had a nonlinearity association with stroke risk among RA patients. Conclusions A close monitoring is required for RA patients with dyslipidemia and elevated inflammatory markers, and the primary stroke preventive strategies should be directed against these risk factors. |
Author | Xin, Fangran Wei, Tingting Chen, Meng Liu, Haina Xu, Yunwei Fu, Lingyu |
Author_xml | – sequence: 1 givenname: Fangran surname: Xin fullname: Xin, Fangran organization: Department of Clinical Epidemiology and Evidence-based medicine, The First Affiliated Hospital of China Medical University – sequence: 2 givenname: Lingyu surname: Fu fullname: Fu, Lingyu email: fulingyucmu@sina.com organization: Department of Clinical Epidemiology and Evidence-based medicine, The First Affiliated Hospital of China Medical University, Department of Medical Record Management Center, The First Affiliated Hospital, China Medical University – sequence: 3 givenname: Haina surname: Liu fullname: Liu, Haina organization: Department of Rheumatology, The First Affiliated Hospital, China Medical University – sequence: 4 givenname: Yunwei surname: Xu fullname: Xu, Yunwei organization: Department of Medical Record Management Center, The First Affiliated Hospital, China Medical University – sequence: 5 givenname: Tingting surname: Wei fullname: Wei, Tingting organization: Department of Clinical Epidemiology and Evidence-based medicine, The First Affiliated Hospital of China Medical University – sequence: 6 givenname: Meng surname: Chen fullname: Chen, Meng organization: Department of Clinical Epidemiology and Evidence-based medicine, The First Affiliated Hospital of China Medical University |
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SubjectTerms | Aged Aged, 80 and over Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - complications Biomarkers - blood Blood Sedimentation Brain Ischemia - blood Brain Ischemia - complications C-Reactive Protein - analysis China Dyslipidemia Dyslipidemias - blood Dyslipidemias - complications Electronic Health Records Electronic medical records Female Humans Inflammation Inflammation - blood Inflammation - complications Lipids Lipids - blood Logistic Models Low density lipoprotein Male Medical records Medicine Medicine & Public Health Metabolic disorders Middle Aged Multivariate Analysis Nonlinear systems Original Article Rheumatoid arthritis Rheumatology Risk Factors Serum lipids Stroke Stroke - blood Stroke - complications |
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Title | Exploring metabolic and inflammatory abnormalities in rheumatoid arthritis patients developing stroke disease: a case-control study using electronic medical record data in northern China |
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