Evolutionary Expression of HER2 Conferred by Chromosome Aneuploidy on Circulating Gastric Cancer Cells Contributes to Developing Targeted and Chemotherapeutic Resistance

• Published in: Clinical cancer research Vol. 24; no. 21; pp. 5261 - 5271
• Main Authors: Li, Yilin, Zhang, Xiaotian, Liu, Dan, Gong, Jifang, Wang, Daisy Dandan, Li, Shan, Peng, Zhi, Li, Yanyan, Wang, Xiaojuan, Lin, Peter Ping, Li, Min, Shen, Lin
• Format: Journal Article
• Language: English
• Published: United States 01.11.2018

Purpose: Previous human epidermal growth factor receptor-2 (HER2)-derived resistance studies were based on ex vivo models, which could not mirror evolutionary expression of HER2 during therapy. To investigate dynamic expression of HER2 and its contribution to developing therapeutic resistance confer...