Is antiviral treatment at the acute phase of COVID-19 effective for decreasing the risk of long-COVID? A systematic review
Purpose Preliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventing long-COVID. This review investigates if having received pharmacological treatment during acute SARS-CoV-2 infection may reduce the risk of long-COVID. Methods MEDLINE,...
Saved in:
Published in | Infection Vol. 52; no. 1; pp. 43 - 58 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.02.2024
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Purpose
Preliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventing long-COVID. This review investigates if having received pharmacological treatment during acute SARS-CoV-2 infection may reduce the risk of long-COVID.
Methods
MEDLINE, CINAHL, PubMed, EMBASE, Web of Science databases, as well as medRxiv/bioRxiv preprint servers were searched up to July 15th, 2023. Articles comparing the presence of long-COVID symptoms between individuals who received or not a specific medication, particularly antivirals, during the acute phase of SARS-CoV-2 infection were included. Methodological quality was assessed using the Newcastle–Ottawa Scale or Cochrane’s Risk of Bias (RoB) tool.
Results
From 517 studies identified, 6 peer-reviewed studies and one preprint met all inclusion criteria. The sample included 2683 (
n
= 4) hospitalized COVID-19 survivors and 307,409 (
n
= 3) non-hospitalized patients. The methodological quality was high in 71% of studies (
n
= 5/7). Two studies investigating the effects of Nirmatrelvir/Ritonavir and three studies investigating the effect of Remdesivir reported conflicting results on effectiveness for preventing long-COVID. Three studies investigating the effects of other medication such as Dexamethasone (
n
= 2) or Metformin (
n
= 1) found positive results of these medications for preventing long-COVID.
Conclusion
Available evidence about the effect of medication treatment with antivirals during acute COVID-19 and reduced risk of developing long-COVID is conflicting. Heterogeneous evidence suggests that Remdesivir or Nirmatrelvir/Ritonavir could have a potential protective effect for long-COVID. A limited number of studies demonstrated a potential benefit of other medications such as Dexamethasone or Metformin, but more studies are needed. |
---|---|
AbstractList | PURPOSEPreliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventing long-COVID. This review investigates if having received pharmacological treatment during acute SARS-CoV-2 infection may reduce the risk of long-COVID.METHODSMEDLINE, CINAHL, PubMed, EMBASE, Web of Science databases, as well as medRxiv/bioRxiv preprint servers were searched up to July 15th, 2023. Articles comparing the presence of long-COVID symptoms between individuals who received or not a specific medication, particularly antivirals, during the acute phase of SARS-CoV-2 infection were included. Methodological quality was assessed using the Newcastle-Ottawa Scale or Cochrane's Risk of Bias (Rob) tool.RESULTSFrom 517 studies identified, 6 peer-reviewed studies and one preprint met all inclusion criteria. The sample included 2683 (n = 4) hospitalized COVID-19 survivors and 307,409 (n = 3) non-hospitalized patients. The methodological quality was high in 71% of studies (n = 5/7). Two studies investigating the effects of Nirmaltrevir/Ritonavir and three studies the effect of Remdesivir reported conflicting results on effectiveness for preventing long-COVID. Three studies investigating the effects of other medication such as Dexamethasone (n = 2) or Metformin (n = 1) found positive results of these medications for preventing long-COVID.CONCLUSIONAvailable evidence about the effect of medication treatment with antivirals during acute COVID-19 and reduced risk of developing long-COVID is conflicting. Heterogeneous evidence suggests that Remdesivir or Nirmaltrevir/Ritonavir could have a potential protective effect for long-COVID. A limited number of studies demonstrated a potential benefit of other medications such as Dexamethasone or Metformin, but more studies are needed. Purpose Preliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventing long-COVID. This review investigates if having received pharmacological treatment during acute SARS-CoV-2 infection may reduce the risk of long-COVID. Methods MEDLINE, CINAHL, PubMed, EMBASE, Web of Science databases, as well as medRxiv/bioRxiv preprint servers were searched up to July 15th, 2023. Articles comparing the presence of long-COVID symptoms between individuals who received or not a specific medication, particularly antivirals, during the acute phase of SARS-CoV-2 infection were included. Methodological quality was assessed using the Newcastle–Ottawa Scale or Cochrane’s Risk of Bias (RoB) tool. Results From 517 studies identified, 6 peer-reviewed studies and one preprint met all inclusion criteria. The sample included 2683 ( n = 4) hospitalized COVID-19 survivors and 307,409 ( n = 3) non-hospitalized patients. The methodological quality was high in 71% of studies ( n = 5/7). Two studies investigating the effects of Nirmatrelvir/Ritonavir and three studies investigating the effect of Remdesivir reported conflicting results on effectiveness for preventing long-COVID. Three studies investigating the effects of other medication such as Dexamethasone ( n = 2) or Metformin ( n = 1) found positive results of these medications for preventing long-COVID. Conclusion Available evidence about the effect of medication treatment with antivirals during acute COVID-19 and reduced risk of developing long-COVID is conflicting. Heterogeneous evidence suggests that Remdesivir or Nirmatrelvir/Ritonavir could have a potential protective effect for long-COVID. A limited number of studies demonstrated a potential benefit of other medications such as Dexamethasone or Metformin, but more studies are needed. Preliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventing long-COVID. This review investigates if having received pharmacological treatment during acute SARS-CoV-2 infection may reduce the risk of long-COVID. MEDLINE, CINAHL, PubMed, EMBASE, Web of Science databases, as well as medRxiv/bioRxiv preprint servers were searched up to July 15th, 2023. Articles comparing the presence of long-COVID symptoms between individuals who received or not a specific medication, particularly antivirals, during the acute phase of SARS-CoV-2 infection were included. Methodological quality was assessed using the Newcastle-Ottawa Scale or Cochrane's Risk of Bias (Rob) tool. From 517 studies identified, 6 peer-reviewed studies and one preprint met all inclusion criteria. The sample included 2683 (n = 4) hospitalized COVID-19 survivors and 307,409 (n = 3) non-hospitalized patients. The methodological quality was high in 71% of studies (n = 5/7). Two studies investigating the effects of Nirmaltrevir/Ritonavir and three studies the effect of Remdesivir reported conflicting results on effectiveness for preventing long-COVID. Three studies investigating the effects of other medication such as Dexamethasone (n = 2) or Metformin (n = 1) found positive results of these medications for preventing long-COVID. Available evidence about the effect of medication treatment with antivirals during acute COVID-19 and reduced risk of developing long-COVID is conflicting. Heterogeneous evidence suggests that Remdesivir or Nirmaltrevir/Ritonavir could have a potential protective effect for long-COVID. A limited number of studies demonstrated a potential benefit of other medications such as Dexamethasone or Metformin, but more studies are needed. PurposePreliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventing long-COVID. This review investigates if having received pharmacological treatment during acute SARS-CoV-2 infection may reduce the risk of long-COVID.MethodsMEDLINE, CINAHL, PubMed, EMBASE, Web of Science databases, as well as medRxiv/bioRxiv preprint servers were searched up to July 15th, 2023. Articles comparing the presence of long-COVID symptoms between individuals who received or not a specific medication, particularly antivirals, during the acute phase of SARS-CoV-2 infection were included. Methodological quality was assessed using the Newcastle–Ottawa Scale or Cochrane’s Risk of Bias (RoB) tool.ResultsFrom 517 studies identified, 6 peer-reviewed studies and one preprint met all inclusion criteria. The sample included 2683 (n = 4) hospitalized COVID-19 survivors and 307,409 (n = 3) non-hospitalized patients. The methodological quality was high in 71% of studies (n = 5/7). Two studies investigating the effects of Nirmatrelvir/Ritonavir and three studies investigating the effect of Remdesivir reported conflicting results on effectiveness for preventing long-COVID. Three studies investigating the effects of other medication such as Dexamethasone (n = 2) or Metformin (n = 1) found positive results of these medications for preventing long-COVID.ConclusionAvailable evidence about the effect of medication treatment with antivirals during acute COVID-19 and reduced risk of developing long-COVID is conflicting. Heterogeneous evidence suggests that Remdesivir or Nirmatrelvir/Ritonavir could have a potential protective effect for long-COVID. A limited number of studies demonstrated a potential benefit of other medications such as Dexamethasone or Metformin, but more studies are needed. |
Author | Catahay, Jesus Alfonso Macapagal, Sharina Velasco, Jacqueline Veronica Caldararo, Mario Fernández-de-las-Peñas, César Torres-Macho, Juan Macasaet, Raymart Franco-Moreno, Ana Henry, Brandon Michael Lippi, Giuseppe Notarte, Kin Israel |
Author_xml | – sequence: 1 givenname: César surname: Fernández-de-las-Peñas fullname: Fernández-de-las-Peñas, César email: cesar.fernandez@urjc.es organization: Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos (URJC), Universidad Rey Juan Carlos – sequence: 2 givenname: Juan surname: Torres-Macho fullname: Torres-Macho, Juan organization: Department of Internal Medicine, Hospital Universitario Infanta Leonor-Virgen de La Torre, Department of Medicine, School of Medicine, Universidad Complutense de Madrid – sequence: 3 givenname: Jesus Alfonso surname: Catahay fullname: Catahay, Jesus Alfonso organization: Department of Medicine, Saint Peter’s University Hospital – sequence: 4 givenname: Raymart surname: Macasaet fullname: Macasaet, Raymart organization: Department of Medicine, Monmouth Medical Center – sequence: 5 givenname: Jacqueline Veronica surname: Velasco fullname: Velasco, Jacqueline Veronica organization: Faculty of Medicine and Surgery, University of Santo Tomas – sequence: 6 givenname: Sharina surname: Macapagal fullname: Macapagal, Sharina organization: Department of Medicine, John A. Burns School of Medicine, University of Hawaii – sequence: 7 givenname: Mario surname: Caldararo fullname: Caldararo, Mario organization: Department of Medicine, Saint Peter’s University Hospital – sequence: 8 givenname: Brandon Michael surname: Henry fullname: Henry, Brandon Michael organization: Clinical Laboratory, Division of Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center – sequence: 9 givenname: Giuseppe surname: Lippi fullname: Lippi, Giuseppe organization: Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona – sequence: 10 givenname: Ana surname: Franco-Moreno fullname: Franco-Moreno, Ana organization: Department of Internal Medicine, Hospital Universitario Infanta Leonor-Virgen de La Torre – sequence: 11 givenname: Kin Israel surname: Notarte fullname: Notarte, Kin Israel organization: Department of Pathology, Johns Hopkins University School of Medicine |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38113020$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kU1r3DAQhkVJaDYff6CHIuglF7UjyVrZpxK2absQyCXJVSjyaOPUlreSnJL8-ii7-YAeIhCDmOeZEbz7ZCeMAQn5xOErB9DfElfAgYGQ5XJVMfhAZrySDYNGyx0yAwnAai7me2Q_pVsAUE2lP5I9WXMuQcCMPCwTtSF3d120Pc0RbR4wZGozzTdIrZsy0vWNTUhHTxfnV8sfjDcUvUdXLKR-jLRFV8TUhdVGil3680T3Y1ixjfKdntB0nzIONneORrzr8N8h2fW2T3j0XA_I5c_Ti8Vvdnb-a7k4OWNOapVZBcIKpVqPgjutHVzrWrRcCgQhAGo1t-W05WV1BeBLaed1LcA2paO9PCDH27nrOP6dMGUzdMlh39uA45SMaKDiSvO6KuiX_9DbcYqh_K5QBQAxr1WhxJZycUwpojfr2A023hsO5ikZs03GlGTMJhkDRfr8PHq6HrB9VV6iKIDcAqm0wgrj2-53xj4C-FSYmQ |
CitedBy_id | crossref_primary_10_1515_cclm_2024_0036 crossref_primary_10_1016_j_ijid_2024_02_009 crossref_primary_10_3390_v16060947 crossref_primary_10_1093_infdis_jiae270 crossref_primary_10_1128_cmr_00119_23 |
Cites_doi | 10.1002/jmv.28732 10.1001/jamanetworkopen.2022.42106 10.1371/journal.pmed.1003501 10.3389/fendo.2020.00191 10.1002/rmv.2141 10.1016/j.cell.2022.01.014 10.1111/eci.13429 10.1002/jmv.28852 10.1038/s41467-022-33825-5 10.1056/NEJMoa2116846 10.1007/s10787-023-01204-1 10.1016/S1473-3099(21)00703-9 10.3390/jcm12124158 10.1056/NEJMoa2201662 10.1093/cid/ciab352 10.1093/qjmed/hcab297 10.3389/fimmu.2022.1060840 10.1001/jamainternmed.2023.0743 10.1002/cpt.2603 10.1007/s15010-021-01696-5 10.1136/bmj.l4898 10.1002/jmv.28750 10.1007/s43440-022-00388-7 10.1080/07853890.2022.2034936 10.1056/NEJMoa2118542 10.1001/jama.2022.18931 10.1016/S2213-2600(22)00528-8 10.1056/NEJMoa2021436 10.1101/2020.05.22.111237 10.1101/2022.11.03.22281783 10.1101/2021.11.17.21266392 |
ContentType | Journal Article |
Copyright | The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. |
Copyright_xml | – notice: The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. – notice: 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QL 7U9 8FD C1K FR3 H94 K9. M7N NAPCQ P64 RC3 7X8 |
DOI | 10.1007/s15010-023-02154-0 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Bacteriology Abstracts (Microbiology B) Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Algology Mycology and Protozoology Abstracts (Microbiology C) Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Nursing & Allied Health Premium Genetics Abstracts Virology and AIDS Abstracts Technology Research Database Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Engineering Research Database Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE Nursing & Allied Health Premium |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1439-0973 |
EndPage | 58 |
ExternalDocumentID | 10_1007_s15010_023_02154_0 38113020 |
Genre | Systematic Review Journal Article Review |
GroupedDBID | --- -53 -5E -5G -BR -EM -Y2 -~C .86 .GJ .VR 04C 06C 06D 0R~ 0VY 199 1N0 1SB 203 28- 29I 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 36B 3O- 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5RE 5VS 67Z 6NX 78A 7RV 7X7 88E 8AO 8C1 8FI 8FJ 8UJ 95- 95. 95~ 96X AAAVM AABHQ AABYN AAEOY AAFGU AAHNG AAIAL AAJKR AAKSU AANXM AANZL AARHV AARTL AATNV AATVU AAUYE AAWCG AAWTL AAYFA AAYIU AAYQN AAYTO ABAKF ABBBX ABBXA ABDZT ABECU ABFGW ABFTV ABHLI ABHQN ABIPD ABJNI ABJOX ABKAS ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABSXP ABTEG ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACBMV ACBRV ACBXY ACBYP ACGFS ACHSB ACHXU ACIGE ACIPQ ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACTTH ACUDM ACVWB ACWMK ACZOJ ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADMDM ADOXG ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEEQQ AEFIE AEFTE AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AESTI AETLH AEVLU AEVTX AEXYK AFAFS AFBBN AFEXP AFKRA AFLOW AFNRJ AFQWF AFRAH AFWTZ AFZKB AGAYW AGDGC AGGBP AGGDS AGJBK AGKHE AGMZJ AGQEE AGQMX AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AIMYW AITGF AJBLW AJDOV AJRNO AJZVZ AKMHD AKQUC ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BBWZM BDATZ BENPR BGNMA BKEYQ BPHCQ BVXVI CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 EBD EBLON EBS EIHBH EIOEI EJD EMB EMOBN EN4 ESBYG EX3 F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GRRUI GXS HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ IHE IJ- IKXTQ IMOTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH LAS LLZTM M1P M4Y MA- N2Q N9A NAPCQ NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM P19 P9S PCD PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI RNS ROL RPX RRX RSV RZK S16 S1Z S26 S27 S28 S37 S3B SAP SCLPG SDE SDH SDM SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 T16 TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UNUBA UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK8 WOW Y6R YLTOR Z45 Z7U Z82 Z87 Z8O Z8V Z91 ZGI ZMTXR ZOVNA ~EX ~KM AACDK AAJBT AASML ACDTI AEFQL AGRTI AJOOF ALIPV CGR CUY CVF ECM EIF H13 NPM AAYXX CITATION 7QL 7U9 8FD C1K FR3 H94 K9. M7N P64 RC3 7X8 |
ID | FETCH-LOGICAL-c375t-402a255dfe21c77c0b782d132e02200856aaaade02a7400f2a7d68820a96aa7f3 |
IEDL.DBID | U2A |
ISSN | 0300-8126 |
IngestDate | Fri Aug 16 09:42:34 EDT 2024 Fri Sep 13 09:29:01 EDT 2024 Thu Sep 12 19:56:26 EDT 2024 Sat Sep 28 08:22:46 EDT 2024 Sat Mar 09 01:37:01 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | Long-COVID Antiviral Nirmatrelvir/Ritonavir Remdesivir Review Post-COVID-19 Nirmaltrevir/Ritonavir |
Language | English |
License | 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c375t-402a255dfe21c77c0b782d132e02200856aaaade02a7400f2a7d68820a96aa7f3 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Undefined-4 |
PMID | 38113020 |
PQID | 2918402685 |
PQPubID | 29907 |
PageCount | 16 |
ParticipantIDs | proquest_miscellaneous_2904157184 proquest_journals_2918402685 crossref_primary_10_1007_s15010_023_02154_0 pubmed_primary_38113020 springer_journals_10_1007_s15010_023_02154_0 |
PublicationCentury | 2000 |
PublicationDate | 2024-02-01 |
PublicationDateYYYYMMDD | 2024-02-01 |
PublicationDate_xml | – month: 02 year: 2024 text: 2024-02-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | Berlin/Heidelberg |
PublicationPlace_xml | – name: Berlin/Heidelberg – name: Germany – name: New York |
PublicationSubtitle | A Journal of Infectious Diseases |
PublicationTitle | Infection |
PublicationTitleAbbrev | Infection |
PublicationTitleAlternate | Infection |
PublicationYear | 2024 |
Publisher | Springer Berlin Heidelberg Springer Nature B.V |
Publisher_xml | – name: Springer Berlin Heidelberg – name: Springer Nature B.V |
References | Horby, Lim, Emberson, Mafham, Bell, Linsell, Staplin, Brightling, Ustianowski, Elmahi, Prudon, Green, Felton, Chadwick, Rege, Fegan, Chappell, Faust, Jaki, Jeffery, Montgomery, Rowan, Juszczak, Baillie, Haynes, Landray (CR32) 2021; 384 Badenes Bonet, Caguana Vélez, Duran Jordà (CR22) 2023; 12 Hammond, Leister-Tebbe, Gardner, Abreu, Bao, Wisemandle, Baniecki, Hendrick, Damle, Simón-Campos, Pypstra, Rusnak (CR5) 2022; 386 Peluso, Anglin, Durstenfeld (CR15) 2022; 7 Kim, An, Kim, Hwang (CR1) 2020; 17 CR18 Chuang, Wu, Liu, Hsu, Tsai, Huang, Lai (CR25) 2023; 95 Bramante, Buse, Liebovitz (CR26) 2023; S1473–3099 Bramante, Huling, Tignanelli (CR37) 2022; 387 Mulchandani, Lyngdoh, Kakkar (CR38) 2021; 51 Boglione, Meli, Poletti, Rostagno, Moglia, Cantone, Esposito, Scianguetta, Domenicale, Di Pasquale, Borrè (CR21) 2022; 114 Coomes, Haghbayan (CR39) 2020; 30 Gottlieb, Vaca, Paredes, Mera, Webb, Perez, Oguchi, Ryan, Nielsen, Brown, Hidalgo, Sachdeva, Mittal, Osiyemi, Skarbinski, Juneja, Hyland, Osinusi, Chen, Camus, Abdelghany, Davies, Behenna-Renton, Duff, Marty, Katz, Ginde, Brown, Schiffer, Hill (CR7) 2022; 386 Amstutz, Speich, Mentré (CR6) 2023; 11 Tian, Chen, Feng (CR4) 2023; 95 Soriano, Murthy, Marshall, Relan, Diaz (CR11) 2022; 22 CR30 Page, McKenzie, Bossuyt, Boutron, Hoffmann, Mulrow, Shamseer, Tetzlaff, Akl, Brennan, Chou, Glanville, Grimshaw, Hróbjartsson, Lalu, Li, Loder, Mayo-Wilson, McDonald, McGuinness, Stewart, Thomas, Tricco, Welch, Whiting, Moher (CR17) 2021; 372 Rahmati, Udeh, Yon, Lee, Dolja-Gore, McEVoy, Kenna, Jacob, López Sánchez, Koyanagi, Shin, Smith (CR13) 2023; 95 Fernández-de-las-Peñas, Rodríguez-Jiménez, Cancela-Cilleruelo, Guerrero-Peral, Martín-Guerrero, García-Azorín, Cornejo-Mazzuchelli, Hernández-Barrera, Pellicer-Valero (CR34) 2022; 5 Singh, Toussi, Hackman, Chan, Rao, Allen, Van Eyck, Pawlak, Kadar, Clark, Shi, Anderson, Binks, Menon, Nucci, Bergman (CR29) 2022; 112 Tran, Riveros, Clepier (CR41) 2022; 74 CR3 Xie, Choi, Al-Aly (CR24) 2023; 183 Wen, Chen, Tang, Wang, Zhou, Cheng, Zhou, Wu, Zhang, Feng, Wang, Mao (CR8) 2022; 54 Wulf Hanson, Abbafati (CR12) 2022; 328 Lv, Guo (CR33) 2020; 11 CR28 CR27 Su, Yuan, Chen (CR36) 2022; 185 Rahmah, Abarikwu, Arero, Essouma, Jibril, Fal, Flisiak, Makuku, Marquez, Mohamed, Ndow, Zarębska-Michaluk, Rezaei, Rzymski (CR2) 2022; 74 Zadeh, Wilson, Agrawal (CR9) 2023; 7 Suran (CR14) 2022; 328 Sterne, Savović, Page, Elbers, Blencowe, Boutron, Cates, Cheng, Corbett, Eldridge, Emberson, Hernán, Hopewell, Hróbjartsson, Junqueira, Jüni, Kirkham, Lasserson, Li, McAleenan, Reeves, Shepperd, Shrier, Stewart, Tilling, White, Whiting, Higgins (CR19) 2019; 366 CR20 Nevalainen, Horstia, Laakkonen (CR23) 2022; 13 CR40 Malin, Suárez, Priesner, Fätkenheuer, Rybniker (CR31) 2021; 34 Sebők, Gyires (CR16) 2023 Fernández-de-las-Peñas (CR10) 2022; 50 Kuri-Ayache, Rivera-Cavazos, Pérez-Castillo, Santos-Macías, González-Cantú, Luviano-García, Jaime-Villalón, Gutierrez-González, Romero-Ibarguengoitia (CR35) 2023; 13 38451416 - Infection. 2024 Mar 7 2154_CR28 CT Bramante (2154_CR26) 2023; S1473–3099 2154_CR27 JJ Malin (2154_CR31) 2021; 34 M Rahmati (2154_CR13) 2023; 95 2154_CR3 M Suran (2154_CR14) 2022; 328 L Rahmah (2154_CR2) 2022; 74 RL Gottlieb (2154_CR7) 2022; 386 RSP Singh (2154_CR29) 2022; 112 Z Lv (2154_CR33) 2020; 11 M Kuri-Ayache (2154_CR35) 2023; 13 S Sebők (2154_CR16) 2023 MS Kim (2154_CR1) 2020; 17 C Fernández-de-las-Peñas (2154_CR10) 2022; 50 2154_CR20 S Wulf Hanson (2154_CR12) 2022; 328 MJ Peluso (2154_CR15) 2022; 7 2154_CR40 L Boglione (2154_CR21) 2022; 114 F Zadeh (2154_CR9) 2023; 7 Y Xie (2154_CR24) 2023; 183 2154_CR18 F Tian (2154_CR4) 2023; 95 OPO Nevalainen (2154_CR23) 2022; 13 J Hammond (2154_CR5) 2022; 386 D Badenes Bonet (2154_CR22) 2023; 12 P Horby (2154_CR32) 2021; 384 R Mulchandani (2154_CR38) 2021; 51 JB Soriano (2154_CR11) 2022; 22 Y Su (2154_CR36) 2022; 185 VT Tran (2154_CR41) 2022; 74 CT Bramante (2154_CR37) 2022; 387 A Amstutz (2154_CR6) 2023; 11 C Fernández-de-las-Peñas (2154_CR34) 2022; 5 EA Coomes (2154_CR39) 2020; 30 MJ Page (2154_CR17) 2021; 372 2154_CR30 MH Chuang (2154_CR25) 2023; 95 JAC Sterne (2154_CR19) 2019; 366 W Wen (2154_CR8) 2022; 54 |
References_xml | – volume: 95 year: 2023 ident: CR4 article-title: Nirmatrelvir-ritonavir compared with other antiviral drugs for the treatment of COVID-19 patients: a systematic review and meta-analysis publication-title: J Med Virol doi: 10.1002/jmv.28732 contributor: fullname: Feng – volume: 372 year: 2021 ident: CR17 article-title: The PRISMA 2020 statement: an updated guideline for reporting systematic reviews publication-title: BMJ contributor: fullname: Moher – volume: 5 year: 2022 ident: CR34 article-title: Post-COVID-19 symptoms 2 years after SARS-CoV-2 infection among hospitalized vs non-hospitalized patients publication-title: JAMA Netw Open doi: 10.1001/jamanetworkopen.2022.42106 contributor: fullname: Pellicer-Valero – ident: CR18 – volume: 34 start-page: e00162 year: 2021 end-page: e220 ident: CR31 article-title: Remdesivir against COVID-19 and other viral diseases publication-title: Clin Microbiol Rev contributor: fullname: Rybniker – volume: 17 year: 2020 ident: CR1 article-title: Comparative efficacy and safety of pharmacological interventions for the treatment of COVID-19: a systematic review and network meta-analysis publication-title: PLoS Med doi: 10.1371/journal.pmed.1003501 contributor: fullname: Hwang – ident: CR30 – volume: 11 start-page: 191 year: 2020 ident: CR33 article-title: Metformin and its benefits for various diseases publication-title: Front Endocrinol doi: 10.3389/fendo.2020.00191 contributor: fullname: Guo – volume: 30 start-page: 1 year: 2020 end-page: 9 ident: CR39 article-title: Interleukin-6 in COVID-19: a systematic review and meta-analysis publication-title: Rev Med Virol doi: 10.1002/rmv.2141 contributor: fullname: Haghbayan – volume: 185 start-page: 881 year: 2022 end-page: 895 ident: CR36 article-title: Multiple early factors anticipate post-acute COVID-19 sequelae publication-title: Cell doi: 10.1016/j.cell.2022.01.014 contributor: fullname: Chen – volume: 51 year: 2021 ident: CR38 article-title: Deciphering the COVID-19 cytokine storm: systematic review and meta-analysis publication-title: Eur J Clin Invest doi: 10.1111/eci.13429 contributor: fullname: Kakkar – volume: 95 year: 2023 ident: CR13 article-title: A systematic review and meta-analysis of long-term sequelae of COVID-19 2-year after SARS-CoV-2 infection: a call to action for neurological, physical, and psychological sciences publication-title: J Med Virol doi: 10.1002/jmv.28852 contributor: fullname: Smith – ident: CR40 – volume: 13 start-page: 6152 year: 2022 ident: CR23 article-title: Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial publication-title: Nat Commun doi: 10.1038/s41467-022-33825-5 contributor: fullname: Laakkonen – ident: CR27 – volume: 386 start-page: 305 year: 2022 end-page: 315 ident: CR7 article-title: Early remdesivir to prevent progression to severe COVID-19 in outpatients publication-title: N Engl J Med doi: 10.1056/NEJMoa2116846 contributor: fullname: Hill – volume: 328 start-page: 2386 year: 2022 ident: CR14 article-title: VA Finds nirmatrelvir associated with lower risk of long COVID publication-title: JAMA contributor: fullname: Suran – year: 2023 ident: CR16 article-title: Long COVID and possible preventive options publication-title: Inflammopharmacology doi: 10.1007/s10787-023-01204-1 contributor: fullname: Gyires – volume: 22 start-page: e102 year: 2022 end-page: e107 ident: CR11 article-title: A clinical case definition of post-COVID-19 condition by a Delphi consensus publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(21)00703-9 contributor: fullname: Diaz – volume: 7 start-page: 36 year: 2023 end-page: 61 ident: CR9 article-title: Long COVID: complications, underlying mechanisms, and treatment strategies publication-title: Arch Microbiol Immunol contributor: fullname: Agrawal – volume: 12 start-page: 4158 year: 2023 ident: CR22 article-title: Treatment of COVID-19 during the acute phase in hospitalized patients decreases post-acute sequelae of COVID-19 publication-title: J Clin Med doi: 10.3390/jcm12124158 contributor: fullname: Duran Jordà – volume: 387 start-page: 599 year: 2022 end-page: 610 ident: CR37 article-title: Randomized trial of metformin, ivermectin, and fluvoxamine for COVID-19 publication-title: N Engl J Med doi: 10.1056/NEJMoa2201662 contributor: fullname: Tignanelli – volume: 74 start-page: 278 year: 2022 end-page: 287 ident: CR41 article-title: Development and validation of the long COVID symptom and impact tools, a set of patient-reported instruments constructed from patients’ lived experience publication-title: Clin Infect Dis doi: 10.1093/cid/ciab352 contributor: fullname: Clepier – volume: 114 start-page: 865 year: 2022 end-page: 871 ident: CR21 article-title: Risk factors and incidence of long-COVID syndrome in hospitalized patients: does remdesivir have a protective effect? publication-title: QJM doi: 10.1093/qjmed/hcab297 contributor: fullname: Borrè – volume: S1473–3099 start-page: 00299 year: 2023 end-page: 302 ident: CR26 article-title: Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomised, quadruple-blind, parallel-group, phase 3 trial publication-title: Lancet Infect Dis contributor: fullname: Liebovitz – volume: 13 start-page: 1060840 year: 2023 ident: CR35 article-title: Viral load and its relationship with the inflammatory response and clinical outcomes in hospitalization of patients with COVID-19 publication-title: Front Immunol doi: 10.3389/fimmu.2022.1060840 contributor: fullname: Romero-Ibarguengoitia – volume: 183 start-page: 554 year: 2023 end-page: 564 ident: CR24 article-title: Association of treatment with nirmatrelvir and the risk of post-COVID-19 condition publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2023.0743 contributor: fullname: Al-Aly – volume: 112 start-page: 101 year: 2022 end-page: 111 ident: CR29 article-title: Innovative Randomized phase i study and dosing regimen selection to accelerate and inform pivotal COVID-19 trial of Nirmatrelvir publication-title: Clin Pharmacol Ther doi: 10.1002/cpt.2603 contributor: fullname: Bergman – ident: CR3 – volume: 7 start-page: 95 year: 2022 end-page: 103 ident: CR15 article-title: Effect of oral nirmatrelvir on long COVID symptoms: 4 cases and rationale for systematic studies publication-title: Pathog Immun contributor: fullname: Durstenfeld – volume: 50 start-page: 285 year: 2022 end-page: 286 ident: CR10 article-title: Long COVID: current definition publication-title: Infection doi: 10.1007/s15010-021-01696-5 contributor: fullname: Fernández-de-las-Peñas – volume: 366 year: 2019 ident: CR19 article-title: RoB 2: a revised tool for assessing risk of bias in randomised trials publication-title: BMJ doi: 10.1136/bmj.l4898 contributor: fullname: Higgins – volume: 95 year: 2023 ident: CR25 article-title: Efficacy of nirmatrelvir and ritonavir for post-acute COVID-19 sequelae beyond 3 months of SARS-CoV-2 infection publication-title: J Med Virol doi: 10.1002/jmv.28750 contributor: fullname: Lai – volume: 74 start-page: 1255 year: 2022 end-page: 1278 ident: CR2 article-title: Oral antiviral treatments for COVID-19: opportunities and challenges publication-title: Pharmacol Rep doi: 10.1007/s43440-022-00388-7 contributor: fullname: Rzymski – volume: 54 start-page: 516 year: 2022 end-page: 523 ident: CR8 article-title: Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and paxlovid) for COVID-19: a meta-analysis publication-title: Ann Med doi: 10.1080/07853890.2022.2034936 contributor: fullname: Mao – ident: CR28 – volume: 386 start-page: 1397 year: 2022 end-page: 1408 ident: CR5 article-title: Oral nirmatrelvir for high-risk, non-hospitalized adults with COVID-19 publication-title: N Engl J Med doi: 10.1056/NEJMoa2118542 contributor: fullname: Rusnak – volume: 328 start-page: 1604 year: 2022 end-page: 1615 ident: CR12 article-title: Estimated global proportions of individuals with persistent fatigue, cognitive, and respiratory symptom clusters following symptomatic COVID-19 in 2020 and 2021 publication-title: JAMA doi: 10.1001/jama.2022.18931 contributor: fullname: Abbafati – volume: 11 start-page: 453 year: 2023 end-page: 464 ident: CR6 article-title: Effects of remdesivir in patients hospitalised with COVID-19: a systematic review and individual patient data meta-analysis of randomised controlled trials publication-title: Lancet Respir Med doi: 10.1016/S2213-2600(22)00528-8 contributor: fullname: Mentré – ident: CR20 – volume: 384 start-page: 693 year: 2021 end-page: 704 ident: CR32 article-title: Dexamethasone in hospitalized patients with COVID-19 publication-title: N Engl J Med doi: 10.1056/NEJMoa2021436 contributor: fullname: Landray – volume: 13 start-page: 1060840 year: 2023 ident: 2154_CR35 publication-title: Front Immunol doi: 10.3389/fimmu.2022.1060840 contributor: fullname: M Kuri-Ayache – volume: 5 year: 2022 ident: 2154_CR34 publication-title: JAMA Netw Open doi: 10.1001/jamanetworkopen.2022.42106 contributor: fullname: C Fernández-de-las-Peñas – volume: 17 year: 2020 ident: 2154_CR1 publication-title: PLoS Med doi: 10.1371/journal.pmed.1003501 contributor: fullname: MS Kim – ident: 2154_CR3 – volume: 112 start-page: 101 year: 2022 ident: 2154_CR29 publication-title: Clin Pharmacol Ther doi: 10.1002/cpt.2603 contributor: fullname: RSP Singh – volume: 34 start-page: e00162 year: 2021 ident: 2154_CR31 publication-title: Clin Microbiol Rev contributor: fullname: JJ Malin – volume: 95 year: 2023 ident: 2154_CR13 publication-title: J Med Virol doi: 10.1002/jmv.28852 contributor: fullname: M Rahmati – volume: 11 start-page: 191 year: 2020 ident: 2154_CR33 publication-title: Front Endocrinol doi: 10.3389/fendo.2020.00191 contributor: fullname: Z Lv – volume: 12 start-page: 4158 year: 2023 ident: 2154_CR22 publication-title: J Clin Med doi: 10.3390/jcm12124158 contributor: fullname: D Badenes Bonet – ident: 2154_CR28 – volume: S1473–3099 start-page: 00299 year: 2023 ident: 2154_CR26 publication-title: Lancet Infect Dis contributor: fullname: CT Bramante – volume: 366 year: 2019 ident: 2154_CR19 publication-title: BMJ doi: 10.1136/bmj.l4898 contributor: fullname: JAC Sterne – volume: 114 start-page: 865 year: 2022 ident: 2154_CR21 publication-title: QJM doi: 10.1093/qjmed/hcab297 contributor: fullname: L Boglione – volume: 372 year: 2021 ident: 2154_CR17 publication-title: BMJ contributor: fullname: MJ Page – year: 2023 ident: 2154_CR16 publication-title: Inflammopharmacology doi: 10.1007/s10787-023-01204-1 contributor: fullname: S Sebők – ident: 2154_CR18 – volume: 13 start-page: 6152 year: 2022 ident: 2154_CR23 publication-title: Nat Commun doi: 10.1038/s41467-022-33825-5 contributor: fullname: OPO Nevalainen – volume: 384 start-page: 693 year: 2021 ident: 2154_CR32 publication-title: N Engl J Med doi: 10.1056/NEJMoa2021436 contributor: fullname: P Horby – volume: 74 start-page: 278 year: 2022 ident: 2154_CR41 publication-title: Clin Infect Dis doi: 10.1093/cid/ciab352 contributor: fullname: VT Tran – volume: 387 start-page: 599 year: 2022 ident: 2154_CR37 publication-title: N Engl J Med doi: 10.1056/NEJMoa2201662 contributor: fullname: CT Bramante – volume: 11 start-page: 453 year: 2023 ident: 2154_CR6 publication-title: Lancet Respir Med doi: 10.1016/S2213-2600(22)00528-8 contributor: fullname: A Amstutz – volume: 7 start-page: 36 year: 2023 ident: 2154_CR9 publication-title: Arch Microbiol Immunol contributor: fullname: F Zadeh – volume: 50 start-page: 285 year: 2022 ident: 2154_CR10 publication-title: Infection doi: 10.1007/s15010-021-01696-5 contributor: fullname: C Fernández-de-las-Peñas – volume: 328 start-page: 1604 year: 2022 ident: 2154_CR12 publication-title: JAMA doi: 10.1001/jama.2022.18931 contributor: fullname: S Wulf Hanson – volume: 328 start-page: 2386 year: 2022 ident: 2154_CR14 publication-title: JAMA contributor: fullname: M Suran – volume: 51 year: 2021 ident: 2154_CR38 publication-title: Eur J Clin Invest doi: 10.1111/eci.13429 contributor: fullname: R Mulchandani – ident: 2154_CR40 doi: 10.1101/2020.05.22.111237 – volume: 54 start-page: 516 year: 2022 ident: 2154_CR8 publication-title: Ann Med doi: 10.1080/07853890.2022.2034936 contributor: fullname: W Wen – volume: 185 start-page: 881 year: 2022 ident: 2154_CR36 publication-title: Cell doi: 10.1016/j.cell.2022.01.014 contributor: fullname: Y Su – volume: 386 start-page: 1397 year: 2022 ident: 2154_CR5 publication-title: N Engl J Med doi: 10.1056/NEJMoa2118542 contributor: fullname: J Hammond – ident: 2154_CR30 – volume: 30 start-page: 1 year: 2020 ident: 2154_CR39 publication-title: Rev Med Virol doi: 10.1002/rmv.2141 contributor: fullname: EA Coomes – volume: 22 start-page: e102 year: 2022 ident: 2154_CR11 publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(21)00703-9 contributor: fullname: JB Soriano – volume: 74 start-page: 1255 year: 2022 ident: 2154_CR2 publication-title: Pharmacol Rep doi: 10.1007/s43440-022-00388-7 contributor: fullname: L Rahmah – ident: 2154_CR20 doi: 10.1101/2022.11.03.22281783 – volume: 95 year: 2023 ident: 2154_CR25 publication-title: J Med Virol doi: 10.1002/jmv.28750 contributor: fullname: MH Chuang – volume: 386 start-page: 305 year: 2022 ident: 2154_CR7 publication-title: N Engl J Med doi: 10.1056/NEJMoa2116846 contributor: fullname: RL Gottlieb – volume: 95 year: 2023 ident: 2154_CR4 publication-title: J Med Virol doi: 10.1002/jmv.28732 contributor: fullname: F Tian – volume: 183 start-page: 554 year: 2023 ident: 2154_CR24 publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2023.0743 contributor: fullname: Y Xie – volume: 7 start-page: 95 year: 2022 ident: 2154_CR15 publication-title: Pathog Immun contributor: fullname: MJ Peluso – ident: 2154_CR27 doi: 10.1101/2021.11.17.21266392 |
SSID | ssj0005947 |
Score | 2.4548154 |
SecondaryResourceType | review_article |
Snippet | Purpose
Preliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventing long-COVID. This review... Preliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventing long-COVID. This review... PurposePreliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventing long-COVID. This review... PURPOSEPreliminary evidence suggests a potential effect of antiviral medication used during the acute COVID-19 phase for preventing long-COVID. This review... |
SourceID | proquest crossref pubmed springer |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 43 |
SubjectTerms | Antiviral agents Antiviral Agents - therapeutic use Antiviral drugs Clinical outcomes COVID-19 Dexamethasone Dexamethasone - therapeutic use Drug therapy Drugs Family Medicine General Practice Humans Infectious Diseases Internal Medicine Medicine Medicine & Public Health Metformin Post-Acute COVID-19 Syndrome Quality assessment Recovery (Medical) Review Risk management Ritonavir SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Viral diseases |
Title | Is antiviral treatment at the acute phase of COVID-19 effective for decreasing the risk of long-COVID? A systematic review |
URI | https://link.springer.com/article/10.1007/s15010-023-02154-0 https://www.ncbi.nlm.nih.gov/pubmed/38113020 https://www.proquest.com/docview/2918402685/abstract/ https://search.proquest.com/docview/2904157184 |
Volume | 52 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NS8MwFA-ygXgRv63OEcGbBtqkH-tJurm5KZsXJ_NUsjRRYbTDdRf_el_SbkWmB3sJJV8l7yXv9_o-gtAVCC0plU-Jo7hNAP8rwgVorYETKsdhgnvmSpbhyO-P3YeJN6niuI2z-8oiaQ7qKtbNM3Zbqs2OIPcJ6Ol1DR40K49pVPl1hOZWMWBem4D08stImd_H-CmNNiDmhnnUSJ3eHtot4SKOCvruoy2ZHqDtYWkQP0RfgwWGtfnQrrozvPYaxzzHgOwwF8tc4vk7iCqcKdx5ehncESfEhRcHHHQYMCtODHTUPw1MJ-1trlvPsvSNmC63OMJVymdchLscoXGv-9zpk_I6BSJY4OVaU-SgQCRKUkcEgbCngA4S0EaljrYF6OVzeBJ44wHsbAVF4gMAt3kINYFix6iWZqk8Rdhltpgy7vOWlC6XNLQ9wZTNE-byRLSYha5XyxrPi6wZcZUfWRMhBiLEhgixbaHGauXjcgctYhpq3ZP6Lc9Cl-tq4H1t0OCpzJa6jU4wANLVtdBJQbH1dIBEtE0WBr9ZkbAa_O9vOftf83O0QwHlFG7cDVTLP5fyAlBKPm2ietRrt0e6vH997DYNl34D0J3dtg |
link.rule.ids | 315,786,790,27957,27958,41116,41558,42185,42627,52146,52269 |
linkProvider | Springer Nature |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NS8MwFA8yQb2I31anRvCmgTbpx3qSMR2bbvOyyW4hSxMVRjdcd_Gv9yVtV2R6sJdS8tGSl-T9Xn_vvSB0A0pLKR1S4mnhEsD_mggJVmvkxdrzmBSBPZKlPwg7I_9pHIyLoLBF6e1eUpJ2p66C3QJL3FLDO4LiJ2Cob5p86sbkGtFm5dgR22PFYPa6BNRXWITK_N7HT3W0hjHX-FGrdtp7aLfAi7iZC3gfbaj0AG31C0b8EH11FxgG58P46k7xym0ciwwDtMNCLjOF5--gq_BM49bLa_eBeDHO3Thgp8MAWnFisaP5a2AbGXdzU3s6S9-IbXKPm7jK-YzzeJcjNGo_DlsdUpynQCSLgsyYigIsiEQr6skoku4E4EEC5qgy4baAvUIBVwJPIoKlreGWhIDAXRFDSaTZMaqls1SdIuwzV06YCEVDKV8oGruBZNoVCfNFIhvMQbflsPJ5njaDVwmSjRA4CIFbIXDXQfVy5HmxhBacxsb4pGEjcND1qhgmv2E0RKpmS1PHZBgA9eo76CSX2Op1AEUMKQud35UirDr_-1vO_lf9Cm13hv0e73UHz-dohwLkyX2666iWfS7VBUCWbHJpZ-g3wZXeAQ |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LS8NAEF5EoXgR30arruBNl27ezUlKa2nVVg9WegvbfahQkmLTi7_e2U3SKNWDuYSwr7Czm_km880sQpegtKRUgUNsxSgB_K8I42C1hnakbNvlzDdHsgyGQW_k3Y398bcofsN2L12SeUyDztKUZI2ZUI0q8M03TlxH-yABBBAw2je0atSkrpHTqkgekTliDFYyJaDKgiJs5vc-fqqmFby54is1Kqi7jbYK7IhbubB30JpMdlFtUHjH99Bnf45hot41b3eKlxRyzDIMMA8zvsgknr2B3sKpwu3Hl36H2BHOKR3w1cMAYLEwOFL_QTCNNPVc156mySsxTW5wC1f5n3Ee-7KPRt3b53aPFGcrEO6GfqbNRgbWhFDSsXkYcjoBqCDANJU69BZwWMDgEvDEQtjmCm4iADROWQQloXIP0HqSJvIIYc-lfOKygDWl9Jh0IupzV1EmXI8J3nQtdFVOazzLU2jEVbJkLYQYhBAbIcTUQvVy5uNiO81jJ9KGqBM0fQtdLIthI2jvBktkutB1dLYBULWehQ5ziS2HA1iiHbTQ-XUpwqrzv9_l-H_Vz1HtqdONH_rD-xO06QD6yenddbSefSzkKaCXbHJmFugX7YniRg |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Is+antiviral+treatment+at+the+acute+phase+of+COVID-19+effective+for+decreasing+the+risk+of+long-COVID%3F+A+systematic+review&rft.jtitle=Infection&rft.au=Fern%C3%A1ndez-de-las-Pe%C3%B1as%2C+C%C3%A9sar&rft.au=Torres-Macho%2C+Juan&rft.au=Catahay%2C+Jesus+Alfonso&rft.au=Macasaet%2C+Raymart&rft.date=2024-02-01&rft.pub=Springer+Berlin+Heidelberg&rft.issn=0300-8126&rft.eissn=1439-0973&rft.volume=52&rft.issue=1&rft.spage=43&rft.epage=58&rft_id=info:doi/10.1007%2Fs15010-023-02154-0&rft.externalDocID=10_1007_s15010_023_02154_0 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0300-8126&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0300-8126&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0300-8126&client=summon |