Numerical investigation of patient-specific thoracic aortic aneurysms and comparison with normal subject via computational fluid dynamics (CFD)

• Published in: Medical & biological engineering & computing Vol. 59; no. 1; pp. 71 - 84
• Main Authors: Etli, Mustafa, Canbolat, Gokhan, Karahan, Oguz, Koru, Murat
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2021; Springer Nature B.V
• Subjects: Aneurysms; Angiography; Aorta; Aortic aneurysms; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Blood pressure; Boundary conditions; Cardiovascular diseases; Computational fluid dynamics; Computed tomography; Computer Applications; Flow velocity; Fluid dynamics; Fourier series; Heart; Hemodynamics; Human Physiology; Imaging; Original Article; Radiology; Simulation; Thorax; Wall shear stresses; Computed tomography angiography; Patient-specific simulation; Cardiovascular flow; Thoracic aortic aneurysm; Computational fluid dynamics (CFD)
• DOI: 10.1007/s11517-020-02287-6
• ISSN: 0140-0118; 1741-0444

Vascular hemodynamics play an important role in cardiovascular diseases. This work aimed to investigate the effects of an increase in ascending aortic diameter (AAD) on hemodynamics throughout a cardiac cycle for real patients. In this study, two scans of thoracic aortic aneurysm (TAA) subject with different AADs (42.94 mm and 48.01 mm) and a scan of a normal subject (19.81 mm) were analyzed to assess the effects of hemodynamics on the progression of TAA with the same flow rate. Real-patient aortic geometries were scanned by computed tomography angiography (CTA), and steady and pulsatile flow conditions were used to simulate real patient aortic geometries. Aortic arches were obtained from routine clinical scans. Computational fluid dynamics (CFD) simulations were performed with in vivo boundary conditions, and 3D Navier-Stokes equations were solved by a UDF (user-defined function) code defining a real cardiac cycle of one patient using Fourier series (FS). Wall shear stress (WSS) and pressure distributions were presented from normal subject to TAA cases. The results show that during the peak systolic phase pressure load increased by 18.56% from normal subject to TAA case 1 and by 23.8% from normal subject to TAA case 2 in the aneurysm region. It is concluded that although overall WSS increased in aneurysm cases but was low in dilatation areas. As a result, abnormal changes in WSS and higher pressure load may lead to rupture and risk of further dilatation. CFD simulations were highly effective to guide clinical predictions and assess the progress of aneurysm regions in case of early surgical intervention. Graphical abstract