A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE)

• Published in: American journal of respiratory and critical care medicine Vol. 198; no. 9; pp. 1151 - 1164
• Main Authors: Criner, Gerard J., Sue, Richard, Wright, Shawn, Dransfield, Mark, Rivas-Perez, Hiram, Wiese, Tanya, Sciurba, Frank C., Shah, Pallav L., Wahidi, Momen M., de Oliveira, Hugo Goulart, Morrissey, Brian, Cardoso, Paulo F. G., Hays, Steven, Majid, Adnan, Pastis, Nicholas, Kopas, Lisa, Vollenweider, Mark, McFadden, P. Michael, Machuzak, Michael, Hsia, David W., Sung, Arthur, Jarad, Nabil, Kornaszewska, Malgorzata, Hazelrigg, Stephen, Krishna, Ganesh, Armstrong, Brian, Shargill, Narinder S., Slebos, Dirk-Jan, Cordova, Francis, Desai, Parag, Marchetti, Nathaniel, Kim, Victor, Shenoy, Kartik, Travaline, John, Thomas, Jiji, Criner, Lii-Yoong H., Thornburg, Aaron, Thomas, Terry, Bhatt, Surya, Wells, James Michael, Seabron-Harris, Necole, Gauhar, Umair, Despirito, Crissie, Sciurba, Frank, Bon Field, Jessica, Chandra, Divay, Leader, Joseph, Semaan, Roy, Ledezma, Christina, Shah, Pallav, Kemp, Samuel, Garner, Justin, Aboelhassan, Arafa, Srikanthan, Karthi, Tenda, Eric, Abraham, Anita, Sim, Cai, Wahidi, Momen, Mahmood, Kamran, Shofer, Scott, Coles, Kathleen, Oliveira, Guilherme Augusto, Machado, Betina, Benedetto, Igor, Svartman, Fabio, de Macedo Neto, Amarilio, Schreiner, Leonardo, Vieira, Taiane, Yoneda, Ken, Tham, Tina, Tompkins, Daniel, Guerreiro Cardoso, Paulo F., Athanazio, Rodrigo, Nominando, Felipe, Rached, Samia, Cassimiro, Luciana, Seeley, Eric, Shrestha, Pavan, Dincheva, Gabriela R., Alape-Moya, Daniel, Parikh, Mihir, Paton, Alichia, Agnew, Alexis, Strange, Charlie, Beiko, Tatsiana, Woodford, Danielle, Blanton, Mary, Connolly, Timothy
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.11.2018
• Subjects: Bronchi - surgery; Bronchodilators; Bronchoscopy; Chronic obstructive pulmonary disease; Clinical trials; Dyspnea; Emphysema; Equipment Design; Evidence-based medicine; Exercise Tolerance; FDA approval; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Mortality; Patients; Prostheses and Implants; Pulmonary Emphysema - surgery; Questionnaires; Surgery; Surveys and Questionnaires; Transplants & implants; Treatment Outcome; United States > US; lung reduction; chronic obstructive pulmonary disease; emphysema

This is the first multicenter randomized controlled trial to evaluate the effectiveness and safety of Zephyr Endobronchial Valve (EBV) in patients with little to no collateral ventilation out to 12 months. To evaluate the effectiveness and safety of Zephyr EBV in heterogeneous emphysema with little...