Increased plasma levels of CCL20 in peripheral blood of rheumatoid arthritis patients and its association with clinical and laboratory parameters
Introduction Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects small joints. The impaired chemokine and cytokine responses are essential pathological mechanisms for the RA clinical presentation. Given the role of chemokines and inflammatory reactions in RA pathogenesi...
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Published in | Clinical rheumatology Vol. 41; no. 1; pp. 265 - 270 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Cham
Springer International Publishing
2022
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Abstract | Introduction
Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects small joints. The impaired chemokine and cytokine responses are essential pathological mechanisms for the RA clinical presentation. Given the role of chemokines and inflammatory reactions in RA pathogenesis, we evaluate the association between the plasma concentration of CCL20 with the clinical and laboratory parameters in newly diagnosed RA patients.
Material and methods
Forty-five newly diagnosed RA patients and forty-five healthy subjects were enrolled in this study. The plasma levels of CCL20, rheumatoid factor, and anti-citrullinated peptide antibodies were measured using the enzyme-linked immunosorbent assay (ELISA) technique.
Result
The plasma levels of CCL20 were increased significantly in RA patients compared to the healthy controls (
p
< 0.0001). There was a positive correlation between CCL20 and RF, anti-CCP, ESR, and DAS-28 (
p
< 0.0001,
r
= 0.669;
p
< 0.015,
r
= 0.358;
p
< 0.0001,
r
= 0.586;
p
< 0.0001,
r
= 0.769).
Conclusion
The increased plasma levels of CCL20 in newly diagnosed RA patients may contribute to RA pathogenesis, and it is in association with clinical and laboratory parameters.
Key Points
• CCL20 has a contribution to the early phase of RA. |
---|---|
AbstractList | Introduction
Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects small joints. The impaired chemokine and cytokine responses are essential pathological mechanisms for the RA clinical presentation. Given the role of chemokines and inflammatory reactions in RA pathogenesis, we evaluate the association between the plasma concentration of CCL20 with the clinical and laboratory parameters in newly diagnosed RA patients.
Material and methods
Forty-five newly diagnosed RA patients and forty-five healthy subjects were enrolled in this study. The plasma levels of CCL20, rheumatoid factor, and anti-citrullinated peptide antibodies were measured using the enzyme-linked immunosorbent assay (ELISA) technique.
Result
The plasma levels of CCL20 were increased significantly in RA patients compared to the healthy controls (
p
< 0.0001). There was a positive correlation between CCL20 and RF, anti-CCP, ESR, and DAS-28 (
p
< 0.0001,
r
= 0.669;
p
< 0.015,
r
= 0.358;
p
< 0.0001,
r
= 0.586;
p
< 0.0001,
r
= 0.769).
Conclusion
The increased plasma levels of CCL20 in newly diagnosed RA patients may contribute to RA pathogenesis, and it is in association with clinical and laboratory parameters.
Key Points
• CCL20 has a contribution to the early phase of RA. Abstract Introduction Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects small joints. The impaired chemokine and cytokine responses are essential pathological mechanisms for the RA clinical presentation. Given the role of chemokines and inflammatory reactions in RA pathogenesis, we evaluate the association between the plasma concentration of CCL20 with the clinical and laboratory parameters in newly diagnosed RA patients.Material and methodsForty-five newly diagnosed RA patients and forty-five healthy subjects were enrolled in this study. The plasma levels of CCL20, rheumatoid factor, and anti-citrullinated peptide antibodies were measured using the enzyme-linked immunosorbent assay (ELISA) technique.ResultThe plasma levels of CCL20 were increased significantly in RA patients compared to the healthy controls (p < 0.0001). There was a positive correlation between CCL20 and RF, anti-CCP, ESR, and DAS-28 (p < 0.0001, r = 0.669; p < 0.015, r = 0.358; p < 0.0001, r = 0.586; p < 0.0001, r = 0.769).ConclusionThe increased plasma levels of CCL20 in newly diagnosed RA patients may contribute to RA pathogenesis, and it is in association with clinical and laboratory parameters.Key Points• CCL20 has a contribution to the early phase of RA. INTRODUCTIONRheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects small joints. The impaired chemokine and cytokine responses are essential pathological mechanisms for the RA clinical presentation. Given the role of chemokines and inflammatory reactions in RA pathogenesis, we evaluate the association between the plasma concentration of CCL20 with the clinical and laboratory parameters in newly diagnosed RA patients. MATERIAL AND METHODSForty-five newly diagnosed RA patients and forty-five healthy subjects were enrolled in this study. The plasma levels of CCL20, rheumatoid factor, and anti-citrullinated peptide antibodies were measured using the enzyme-linked immunosorbent assay (ELISA) technique. RESULTThe plasma levels of CCL20 were increased significantly in RA patients compared to the healthy controls (p < 0.0001). There was a positive correlation between CCL20 and RF, anti-CCP, ESR, and DAS-28 (p < 0.0001, r = 0.669; p < 0.015, r = 0.358; p < 0.0001, r = 0.586; p < 0.0001, r = 0.769). CONCLUSIONThe increased plasma levels of CCL20 in newly diagnosed RA patients may contribute to RA pathogenesis, and it is in association with clinical and laboratory parameters. Key Points • CCL20 has a contribution to the early phase of RA. Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects small joints. The impaired chemokine and cytokine responses are essential pathological mechanisms for the RA clinical presentation. Given the role of chemokines and inflammatory reactions in RA pathogenesis, we evaluate the association between the plasma concentration of CCL20 with the clinical and laboratory parameters in newly diagnosed RA patients. Forty-five newly diagnosed RA patients and forty-five healthy subjects were enrolled in this study. The plasma levels of CCL20, rheumatoid factor, and anti-citrullinated peptide antibodies were measured using the enzyme-linked immunosorbent assay (ELISA) technique. The plasma levels of CCL20 were increased significantly in RA patients compared to the healthy controls (p < 0.0001). There was a positive correlation between CCL20 and RF, anti-CCP, ESR, and DAS-28 (p < 0.0001, r = 0.669; p < 0.015, r = 0.358; p < 0.0001, r = 0.586; p < 0.0001, r = 0.769). The increased plasma levels of CCL20 in newly diagnosed RA patients may contribute to RA pathogenesis, and it is in association with clinical and laboratory parameters. Key Points • CCL20 has a contribution to the early phase of RA. |
Author | Roghani, Seyed Askar Soufivand, Parviz Taghadosi, Mahdi Pournazari, Mehran Soleymani, Bijan Feizollahi, Parisa Assar, Shirin Kish, Zahra Mohammadi Bahrehmand, Fariborz |
Author_xml | – sequence: 1 givenname: Mehran surname: Pournazari fullname: Pournazari, Mehran organization: Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences – sequence: 2 givenname: Parisa surname: Feizollahi fullname: Feizollahi, Parisa organization: Student Research Committee, Medical School, Kermanshah University of Medical Sciences, Immunology Department, Faculty of Medicine, Kermanshah University of Medical Sciences – sequence: 3 givenname: Seyed Askar surname: Roghani fullname: Roghani, Seyed Askar organization: Immunology Department, Faculty of Medicine, Kermanshah University of Medical Sciences, Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences – sequence: 4 givenname: Shirin surname: Assar fullname: Assar, Shirin organization: Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences – sequence: 5 givenname: Parviz surname: Soufivand fullname: Soufivand, Parviz organization: Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences – sequence: 6 givenname: Bijan surname: Soleymani fullname: Soleymani, Bijan organization: Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences – sequence: 7 givenname: Fariborz surname: Bahrehmand fullname: Bahrehmand, Fariborz organization: Medical Biology Research Center, Kermanshah University of Medical Sciences – sequence: 8 givenname: Zahra Mohammadi surname: Kish fullname: Kish, Zahra Mohammadi organization: Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences – sequence: 9 givenname: Mahdi orcidid: 0000-0002-3516-0130 surname: Taghadosi fullname: Taghadosi, Mahdi email: mtaghad@gmail.com organization: Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34477989$$D View this record in MEDLINE/PubMed |
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Copyright | International League of Associations for Rheumatology (ILAR) 2021 2021. International League of Associations for Rheumatology (ILAR). International League of Associations for Rheumatology (ILAR) 2021. |
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Keywords | DAS28 RF Anti-CCP CCL20 Rheumatoid arthritis Chemokines |
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Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects small joints. The impaired chemokine and cytokine responses are... Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects small joints. The impaired chemokine and cytokine responses are essential... Abstract Introduction Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects small joints. The impaired chemokine and cytokine... INTRODUCTIONRheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects small joints. The impaired chemokine and cytokine responses are... |
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SubjectTerms | Arthritis, Rheumatoid Autoantibodies Autoimmune diseases Biomarkers CCL20 protein Chemokine CCL20 Chemokines Citrulline Cytokines Enzyme-Linked Immunosorbent Assay Humans Inflammation Joint diseases Laboratories Medicine Medicine & Public Health Original Article Pathogenesis Patients Peptides, Cyclic Peripheral blood Plasma Plasma levels Rheumatoid arthritis Rheumatoid Factor Rheumatology |
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Title | Increased plasma levels of CCL20 in peripheral blood of rheumatoid arthritis patients and its association with clinical and laboratory parameters |
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