Entecavir combining Chinese herbal medicine for HBeAg-positive chronic hepatitis B patients: a randomized, controlled trial

• Published in: Hepatology international Vol. 14; no. 6; pp. 985 - 996
• Main Authors: Li, Xiaoke, Zhou, Daqiao, Chi, Xiaoling, Li, Qin, Wang, Li, Lu, Bingjiu, Mao, Dewen, Wu, Qikai, Wang, Xianbo, Zhang, Mingxiang, Xue, Jingdong, Li, Yong, Lu, Wei, Guo, Jianchun, Jiang, Feng, Zhang, Xinwei, Li, Zhiguo, Yang, Xianzhao, Guo, Hui, Gan, Danan, He, Liyun, Luo, Lin, Zhang, Ludan, Du, Hongbo, Ye, Yong’an
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.12.2020; Springer Nature B.V
• Subjects: Adverse events; Antigens; Antiviral Agents - therapeutic use; Antiviral drugs; Clinical trials; Colorectal Surgery; Deoxyribonucleic acid; DNA; DNA, Viral; Drug Combinations; Drugs, Chinese Herbal - therapeutic use; Enzymes; Granular materials; Guanine - analogs & derivatives; Guanine - therapeutic use; Hepatitis; Hepatitis B; Hepatitis B e antigen; Hepatitis B e Antigens; Hepatitis B surface antigen; Hepatitis B virus - genetics; Hepatitis B, Chronic - drug therapy; Hepatology; Herbal medicine; Humans; Liver; Medicine; Medicine & Public Health; Nucleoside analogs; Original Article; Placebos; Statistical analysis; Surgery; Therapy; Traditional Chinese medicine; Treatment Outcome; Traditional Chinese medicine; Tiao-gan-yi-pi granule; Chronic hepatitis B; Tiao-gan-jian-pi-jie-du granule

Background and aim Traditional Chinese medicine (TCM) is widely accepted and prescribed in China alongside Nucleoside analogs (NAs). In this double-blind, placebo-controlled, randomized, multi-center trial, we evaluated whether entecavir (ETV) plus TCM formulas Tiao-Gan-Yi-Pi granule (TGYP) and Tiao...